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Can soy isoflavones plus soy protein change serum levels of interlukin-6? A systematic review and meta-analysis of randomized controlled trials.
Phytother Res. 2021 Mar; 35(3):1147-1162.PR

Abstract

In the present review, we aimed to summarize the effect of soy isoflavones plus soy protein on circulating interlukin-6 (IL-6) in adult participants. Databases including ISI Web of Science, PubMed, Scopus, Cochrane Library, and clinicaltrials.gov were searched up to 23 March 2020. The mean change from baseline of IL-6 concentrations and its SD for intervention and comparison groups were used to calculate the effect size. If the heterogeneity test was statistically significant, DerSimonian and Laird random effects model was used. Cochran's Q test and I-squared statistic were also used to compute the statistical heterogeneity of the intervention's effects. Eighteen studies were known to be eligible for systematic review and 14 studies were selected for meta-analysis. Our meta-analysis results indicated a non-significant effect in serum IL-6 concentrations compared to the comparison group (WMD = 0.03 pg/ml, 95% CI: -0.06, 0.12; p = .459). In subgroup analysis, based on soy isoflavones dosage, it was observed that this combination could reduce IL-6 levels in studies that used isoflavones with dose >84 mg/day (WMD = -0.12 pg/ml 95% CI: -0.24, -0.004; p = .042, I2 = 82.7%) and in articles with a good quality (WMD = -0.15 pg/ml 95% CI: -0.24, -0.05; p = .003, I2 = 62.3%). Performing well-designed intervention studies using a high dose of soy isoflavones is recommended to confirm the beneficial effects of soy ingredients on IL-6.

Authors+Show Affiliations

Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran.Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Ageing Clinical and Experimental Research Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition University of Aberdeen, Aberdeen, UK.Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

33047387

Citation

Gholami, Ali, et al. "Can Soy Isoflavones Plus Soy Protein Change Serum Levels of Interlukin-6? a Systematic Review and Meta-analysis of Randomized Controlled Trials." Phytotherapy Research : PTR, vol. 35, no. 3, 2021, pp. 1147-1162.
Gholami A, Baradaran HR, Hariri M. Can soy isoflavones plus soy protein change serum levels of interlukin-6? A systematic review and meta-analysis of randomized controlled trials. Phytother Res. 2021;35(3):1147-1162.
Gholami, A., Baradaran, H. R., & Hariri, M. (2021). Can soy isoflavones plus soy protein change serum levels of interlukin-6? A systematic review and meta-analysis of randomized controlled trials. Phytotherapy Research : PTR, 35(3), 1147-1162. https://doi.org/10.1002/ptr.6881
Gholami A, Baradaran HR, Hariri M. Can Soy Isoflavones Plus Soy Protein Change Serum Levels of Interlukin-6? a Systematic Review and Meta-analysis of Randomized Controlled Trials. Phytother Res. 2021;35(3):1147-1162. PubMed PMID: 33047387.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can soy isoflavones plus soy protein change serum levels of interlukin-6? A systematic review and meta-analysis of randomized controlled trials. AU - Gholami,Ali, AU - Baradaran,Hamid Reza, AU - Hariri,Mitra, Y1 - 2020/10/12/ PY - 2020/08/15/revised PY - 2020/05/30/received PY - 2020/08/31/accepted PY - 2020/10/14/pubmed PY - 2021/4/20/medline PY - 2020/10/13/entrez KW - Interleukin-6 KW - Soy Isoflavones KW - inflammatory mediators SP - 1147 EP - 1162 JF - Phytotherapy research : PTR JO - Phytother Res VL - 35 IS - 3 N2 - In the present review, we aimed to summarize the effect of soy isoflavones plus soy protein on circulating interlukin-6 (IL-6) in adult participants. Databases including ISI Web of Science, PubMed, Scopus, Cochrane Library, and clinicaltrials.gov were searched up to 23 March 2020. The mean change from baseline of IL-6 concentrations and its SD for intervention and comparison groups were used to calculate the effect size. If the heterogeneity test was statistically significant, DerSimonian and Laird random effects model was used. Cochran's Q test and I-squared statistic were also used to compute the statistical heterogeneity of the intervention's effects. Eighteen studies were known to be eligible for systematic review and 14 studies were selected for meta-analysis. Our meta-analysis results indicated a non-significant effect in serum IL-6 concentrations compared to the comparison group (WMD = 0.03 pg/ml, 95% CI: -0.06, 0.12; p = .459). In subgroup analysis, based on soy isoflavones dosage, it was observed that this combination could reduce IL-6 levels in studies that used isoflavones with dose >84 mg/day (WMD = -0.12 pg/ml 95% CI: -0.24, -0.004; p = .042, I2 = 82.7%) and in articles with a good quality (WMD = -0.15 pg/ml 95% CI: -0.24, -0.05; p = .003, I2 = 62.3%). Performing well-designed intervention studies using a high dose of soy isoflavones is recommended to confirm the beneficial effects of soy ingredients on IL-6. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/33047387/Can_soy_isoflavones_plus_soy_protein_change_serum_levels_of_interlukin_6_A_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ L2 - https://doi.org/10.1002/ptr.6881 DB - PRIME DP - Unbound Medicine ER -