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Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson's Disease.
Curr Drug Targets. 2021; 22(6):609-630.CD

Abstract

Parkinson's disease is one of the most common adult-onset, a chronic disorder involving neurodegeneration, which progressively leads to deprivation of dopaminergic neurons in substantia nigra, causing a subsequent reduction of dopamine levels in the striatum resulting in tremor, myotonia, and dyskinesia. Genetics and environmental factors are believed to be responsible for the onset of Parkinson's disease. The exact pathogenesis of Parkinson's disease is quite complicated and the present anti-Parkinson's disease treatments appear to be clinically insufficient. Comprehensive researches have demonstrated the use of natural products such as ginseng, curcumin, ashwagandha, baicalein, etc. for the symptomatic treatment of this disease. The neuroprotective effects exhibited by these natural products are mainly due to their ability to increase dopamine levels in the striatum, manage oxidative stress, mitochondrial dysfunction, glutathione levels, clear the aggregation of α- synuclein, induce autophagy and decrease the pro-inflammatory cytokines and lipid peroxidation. This paper reviews various natural product studies conducted by scientists to establish the role of natural products (both metabolite extracts as well as pure metabolites) as adjunctive neuroprotective agents.

Authors+Show Affiliations

Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Xinchuan Road 2222, Chengdu, Sichuan, China.School of Medical and Allied Sciences, K.R. Mangalam University, Sohna Road, Gurugram-122103, India.Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Xinchuan Road 2222, Chengdu, Sichuan, China.Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Xinchuan Road 2222, Chengdu, Sichuan, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

33050857

Citation

Singla, Rajeev K., et al. "Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson's Disease." Current Drug Targets, vol. 22, no. 6, 2021, pp. 609-630.
Singla RK, Agarwal T, He X, et al. Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson's Disease. Curr Drug Targets. 2021;22(6):609-630.
Singla, R. K., Agarwal, T., He, X., & Shen, B. (2021). Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson's Disease. Current Drug Targets, 22(6), 609-630. https://doi.org/10.2174/1389450121999201013155202
Singla RK, et al. Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson's Disease. Curr Drug Targets. 2021;22(6):609-630. PubMed PMID: 33050857.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Herbal Resources to Combat a Progressive & Degenerative Nervous System Disorder- Parkinson's Disease. AU - Singla,Rajeev K, AU - Agarwal,Tanya, AU - He,Xuefei, AU - Shen,Bairong, PY - 2020/04/13/received PY - 2020/06/06/revised PY - 2020/06/12/accepted PY - 2020/10/15/pubmed PY - 2021/11/27/medline PY - 2020/10/14/entrez KW - Dopamine KW - Herbal Medicines KW - Natural Neuroprotective Agents KW - Natural Products KW - Neurodegeneration KW - Parkinson's Disease SP - 609 EP - 630 JF - Current drug targets JO - Curr Drug Targets VL - 22 IS - 6 N2 - Parkinson's disease is one of the most common adult-onset, a chronic disorder involving neurodegeneration, which progressively leads to deprivation of dopaminergic neurons in substantia nigra, causing a subsequent reduction of dopamine levels in the striatum resulting in tremor, myotonia, and dyskinesia. Genetics and environmental factors are believed to be responsible for the onset of Parkinson's disease. The exact pathogenesis of Parkinson's disease is quite complicated and the present anti-Parkinson's disease treatments appear to be clinically insufficient. Comprehensive researches have demonstrated the use of natural products such as ginseng, curcumin, ashwagandha, baicalein, etc. for the symptomatic treatment of this disease. The neuroprotective effects exhibited by these natural products are mainly due to their ability to increase dopamine levels in the striatum, manage oxidative stress, mitochondrial dysfunction, glutathione levels, clear the aggregation of α- synuclein, induce autophagy and decrease the pro-inflammatory cytokines and lipid peroxidation. This paper reviews various natural product studies conducted by scientists to establish the role of natural products (both metabolite extracts as well as pure metabolites) as adjunctive neuroprotective agents. SN - 1873-5592 UR - https://www.unboundmedicine.com/medline/citation/33050857/Herbal_Resources_to_Combat_a_Progressive_&_Degenerative_Nervous_System_Disorder__Parkinson's_Disease_ L2 - https://www.eurekaselect.com/186840/article DB - PRIME DP - Unbound Medicine ER -