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Characteristics of recovered COVID-19 patients with recurrent positive RT-PCR findings in Wuhan, China: a retrospective study.
BMC Infect Dis. 2020 Oct 13; 20(1):749.BI

Abstract

BACKGROUND

Two months after the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, tens of thousands of hospitalized patients had recovered, and little is known about the follow-up of the recovered patients.

METHODS

The clinical characteristics, reverse transcriptase-polymerase chain reaction (RT-PCR) results from throat swab specimens and the results of serological COVID-19 rapid diagnostic test (RDT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were retrospectively reviewed for a total of 758 recovered patients who were previously hospitalized in 17 hospitals and quarantined at 32 rehabilitation stations in Wuhan, China.

RESULTS

In total, 59 patients (7.78%) had recurrent positive findings for COVID-19 on RT-PCR from throat swabs. With regard to antibody detection, 50/59 (84.75%) and 4/59 (6.78%) patients had positive IgG or dual positive IgG/IgM RDT results, respectively.

CONCLUSIONS

Some patients who had been quarantined and had subsequently recovered from COVID-19 had recurrent positive RT-PCR results for SARS-CoV-2, and the possibility of transmission of the virus by recovered patients needs further investigation.

TRIAL REGISTRATION

Current Controlled Trials ChiCTR2000033580 , Jun 6th 2020. Retrospectively registered.

Authors+Show Affiliations

Yunnan Center for Disease Control and Prevention, Kunming, 650011, Yunnan, China.Huangpi District Center for Disease Control and Prevention, Wuhan, 432200, China.Lincang City Center for Disease Control and Prevention, Lincang, 677000, Yunnan, China.Beijing Tropical Medicine Research Institute, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China. hannahchen2003@163.com. Beijing Key Laboratory for Research on Prevention and Treatment of Tropical Diseases, Capital Medical University, Beijing, 100050, China. hannahchen2003@163.com.Chinese Center for Disease Control and Prevention, Beijing, 102206, China. zbk0128@sina.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33050892

Citation

Shui, Tie-Jun, et al. "Characteristics of Recovered COVID-19 Patients With Recurrent Positive RT-PCR Findings in Wuhan, China: a Retrospective Study." BMC Infectious Diseases, vol. 20, no. 1, 2020, p. 749.
Shui TJ, Li C, Liu HB, et al. Characteristics of recovered COVID-19 patients with recurrent positive RT-PCR findings in Wuhan, China: a retrospective study. BMC Infect Dis. 2020;20(1):749.
Shui, T. J., Li, C., Liu, H. B., Chen, X., & Zhang, B. K. (2020). Characteristics of recovered COVID-19 patients with recurrent positive RT-PCR findings in Wuhan, China: a retrospective study. BMC Infectious Diseases, 20(1), 749. https://doi.org/10.1186/s12879-020-05463-z
Shui TJ, et al. Characteristics of Recovered COVID-19 Patients With Recurrent Positive RT-PCR Findings in Wuhan, China: a Retrospective Study. BMC Infect Dis. 2020 Oct 13;20(1):749. PubMed PMID: 33050892.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of recovered COVID-19 patients with recurrent positive RT-PCR findings in Wuhan, China: a retrospective study. AU - Shui,Tie-Jun, AU - Li,Chao, AU - Liu,Hong-Bing, AU - Chen,Xiaohua, AU - Zhang,Bi-Ke, Y1 - 2020/10/13/ PY - 2020/04/16/received PY - 2020/09/30/accepted PY - 2020/10/14/entrez PY - 2020/10/15/pubmed PY - 2020/10/21/medline KW - COVID-19 KW - RT-PCR KW - Recurrent KW - SARS-CoV-2 SP - 749 EP - 749 JF - BMC infectious diseases JO - BMC Infect Dis VL - 20 IS - 1 N2 - BACKGROUND: Two months after the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, tens of thousands of hospitalized patients had recovered, and little is known about the follow-up of the recovered patients. METHODS: The clinical characteristics, reverse transcriptase-polymerase chain reaction (RT-PCR) results from throat swab specimens and the results of serological COVID-19 rapid diagnostic test (RDT) for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were retrospectively reviewed for a total of 758 recovered patients who were previously hospitalized in 17 hospitals and quarantined at 32 rehabilitation stations in Wuhan, China. RESULTS: In total, 59 patients (7.78%) had recurrent positive findings for COVID-19 on RT-PCR from throat swabs. With regard to antibody detection, 50/59 (84.75%) and 4/59 (6.78%) patients had positive IgG or dual positive IgG/IgM RDT results, respectively. CONCLUSIONS: Some patients who had been quarantined and had subsequently recovered from COVID-19 had recurrent positive RT-PCR results for SARS-CoV-2, and the possibility of transmission of the virus by recovered patients needs further investigation. TRIAL REGISTRATION: Current Controlled Trials ChiCTR2000033580 , Jun 6th 2020. Retrospectively registered. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/33050892/Characteristics_of_recovered_COVID_19_patients_with_recurrent_positive_RT_PCR_findings_in_Wuhan_China:_a_retrospective_study_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05463-z DB - PRIME DP - Unbound Medicine ER -