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Lack of tocilizumab effect on mortality in COVID19 patients.
Sci Rep. 2020 10 13; 10(1):17100.SR

Abstract

Off-label tocilizumab use in COVID-19 patients reflects concern for cytokine release syndrome. Comparison of matched COVID-19 pneumonia patients found elevated IL-6 levels correlated with mortality that did not change with tocilizumab administration. Correlating mortality with increased IL-6 doesn't imply causality however lack of improvement by tocilizumab requires further clinical trial alterations.

Authors+Show Affiliations

Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.Division of Pulmonary and Critical Care, University of Miami, Miami, FL, USA. msm249@med.miami.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33051534

Citation

Holt, Gregory E., et al. "Lack of Tocilizumab Effect On Mortality in COVID19 Patients." Scientific Reports, vol. 10, no. 1, 2020, p. 17100.
Holt GE, Batra M, Murthi M, et al. Lack of tocilizumab effect on mortality in COVID19 patients. Sci Rep. 2020;10(1):17100.
Holt, G. E., Batra, M., Murthi, M., Kambali, S., Santos, K., Bastidas, M. V. P., Asif, H., Haddadi, S., Arias, S., & Mirsaeidi, M. (2020). Lack of tocilizumab effect on mortality in COVID19 patients. Scientific Reports, 10(1), 17100. https://doi.org/10.1038/s41598-020-74328-x
Holt GE, et al. Lack of Tocilizumab Effect On Mortality in COVID19 Patients. Sci Rep. 2020 10 13;10(1):17100. PubMed PMID: 33051534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of tocilizumab effect on mortality in COVID19 patients. AU - Holt,Gregory E, AU - Batra,Mayank, AU - Murthi,Mukunthan, AU - Kambali,Shweta, AU - Santos,Kayo, AU - Bastidas,Maria Virginia Perez, AU - Asif,Huda, AU - Haddadi,Sara, AU - Arias,Sixto, AU - Mirsaeidi,Mehdi, Y1 - 2020/10/13/ PY - 2020/07/08/received PY - 2020/09/23/accepted PY - 2020/10/14/entrez PY - 2020/10/15/pubmed PY - 2020/10/29/medline SP - 17100 EP - 17100 JF - Scientific reports JO - Sci Rep VL - 10 IS - 1 N2 - Off-label tocilizumab use in COVID-19 patients reflects concern for cytokine release syndrome. Comparison of matched COVID-19 pneumonia patients found elevated IL-6 levels correlated with mortality that did not change with tocilizumab administration. Correlating mortality with increased IL-6 doesn't imply causality however lack of improvement by tocilizumab requires further clinical trial alterations. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/33051534/Lack_of_tocilizumab_effect_on_mortality_in_COVID19_patients_ L2 - https://doi.org/10.1038/s41598-020-74328-x DB - PRIME DP - Unbound Medicine ER -