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A systematic review and meta-analysis of Liuzijue in stable patients with chronic obstructive pulmonary disease.
BMC Complement Med Ther. 2020 Oct 14; 20(1):308.BC

Abstract

BACKGROUND

To investigate the effectiveness of Liuzijue exercise on chronic obstructive pulmonary disease (COPD) in the stable phase.

METHODS

We searched six electronic bibliographic databases (PubMed, EMBASE, The Cochrane Library, Web of Science, CNKI, and Wan Fang Data) from inception to August 2018. Randomized controlled trials (RCTs) were included if they evaluated the effect of Liuzijue exercise on stable COPD. Cochrane Collaboration risk-of-bias tool (Cochrane Handbook 5.1.0) was used to assess the risk of bias of included RCTs. Meta-analysis was performed using the Review Manager software (RevMan V.5.3.5) provided by the Cochrane Collaboration. Outcomes assessed included dyspnea, exercise capacity, lung function, and quality of life.

RESULTS

Fourteen RCTs involving 920 stable COPD patients were included in this systematic review and meta-analysis. The control groups received usual care. The average number of training sessions per participant was 9.3 per week, and the average length of these training sessions was 31.6 min per week. Training duration varied from 3 to 12 months. Meta-analysis results showed that Liuzijue exercise can effectively improve patients' Modified Medical Research Council Dyspnea Scale scores (MD = - 0.73, 95% CI: - 1.13 to - 0.33, P < 0.05), 6MWD (MD = 17.78, 95% CI: 7.97 to 27.58, P < 0.05), forced expiratory volume in one second (FEV1) (MD = 0.23, 95% CI: 0.07 to 0.38, P < 0.05), the percentage of predicted values of FEV1 (FEV1%pred) (MD = 7.59, 95% CI: 2.92 to 12.26, P < 0.05), FEV1/FVC (Forced vital capacity) ratio (MD = 6.81, 95% CI: 3.22 to 10.40, P < 0.05), Quality of life: St. George's Respiratory Questionnaire total score (MD = - 9.85, 95%CI: - 13.13 to - 6.56, P < 0.05), and Chronic Obstructive Pulmonary Disease Assessment Test score (MD = - 2.29, 95%CI: - 3.27, - 1.30, P < 0.05).

CONCLUSION

Evidence from meta-analysis suggested that Liuzijue exercise could improve dyspnea, exercise endurance, lung function, and quality of life for stable COPD patients. However, owing to the methodological bias and the placebo effect of Liuzijue exercise, there is a need for further research to confirm these findings.

TRIAL REGISTRATION

PROSPERO (ID: CRD42019130973).

Authors+Show Affiliations

School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Department of Rehabilitation, the Second Rehabilitation Hospital of Shanghai, Shanghai, China.School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China.Department of Sports Medicine, Shanghai University of Sport, Shanghai, China.Department of Sports Medicine, Shanghai University of Sport, Shanghai, China.School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China.School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China. hzhp403@126.com. Institute of Rehabilitation Medicine, Shanghai Academy of Traditional Chinese Medicine, Shanghai, China. hzhp403@126.com.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

33054800

Citation

Xiao, Lu, et al. "A Systematic Review and Meta-analysis of Liuzijue in Stable Patients With Chronic Obstructive Pulmonary Disease." BMC Complementary Medicine and Therapies, vol. 20, no. 1, 2020, p. 308.
Xiao L, Duan H, Li P, et al. A systematic review and meta-analysis of Liuzijue in stable patients with chronic obstructive pulmonary disease. BMC Complement Med Ther. 2020;20(1):308.
Xiao, L., Duan, H., Li, P., Wu, W., Shan, C., & Liu, X. (2020). A systematic review and meta-analysis of Liuzijue in stable patients with chronic obstructive pulmonary disease. BMC Complementary Medicine and Therapies, 20(1), 308. https://doi.org/10.1186/s12906-020-03104-1
Xiao L, et al. A Systematic Review and Meta-analysis of Liuzijue in Stable Patients With Chronic Obstructive Pulmonary Disease. BMC Complement Med Ther. 2020 Oct 14;20(1):308. PubMed PMID: 33054800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A systematic review and meta-analysis of Liuzijue in stable patients with chronic obstructive pulmonary disease. AU - Xiao,Lu, AU - Duan,Hongxia, AU - Li,Peijun, AU - Wu,Weibing, AU - Shan,Chunlei, AU - Liu,Xiaodan, Y1 - 2020/10/14/ PY - 2019/05/15/received PY - 2020/10/05/accepted PY - 2020/10/15/entrez PY - 2020/10/16/pubmed PY - 2021/6/24/medline KW - Chronic obstructive pulmonary disease KW - Exercise KW - Liuzijue SP - 308 EP - 308 JF - BMC complementary medicine and therapies JO - BMC Complement Med Ther VL - 20 IS - 1 N2 - BACKGROUND: To investigate the effectiveness of Liuzijue exercise on chronic obstructive pulmonary disease (COPD) in the stable phase. METHODS: We searched six electronic bibliographic databases (PubMed, EMBASE, The Cochrane Library, Web of Science, CNKI, and Wan Fang Data) from inception to August 2018. Randomized controlled trials (RCTs) were included if they evaluated the effect of Liuzijue exercise on stable COPD. Cochrane Collaboration risk-of-bias tool (Cochrane Handbook 5.1.0) was used to assess the risk of bias of included RCTs. Meta-analysis was performed using the Review Manager software (RevMan V.5.3.5) provided by the Cochrane Collaboration. Outcomes assessed included dyspnea, exercise capacity, lung function, and quality of life. RESULTS: Fourteen RCTs involving 920 stable COPD patients were included in this systematic review and meta-analysis. The control groups received usual care. The average number of training sessions per participant was 9.3 per week, and the average length of these training sessions was 31.6 min per week. Training duration varied from 3 to 12 months. Meta-analysis results showed that Liuzijue exercise can effectively improve patients' Modified Medical Research Council Dyspnea Scale scores (MD = - 0.73, 95% CI: - 1.13 to - 0.33, P < 0.05), 6MWD (MD = 17.78, 95% CI: 7.97 to 27.58, P < 0.05), forced expiratory volume in one second (FEV1) (MD = 0.23, 95% CI: 0.07 to 0.38, P < 0.05), the percentage of predicted values of FEV1 (FEV1%pred) (MD = 7.59, 95% CI: 2.92 to 12.26, P < 0.05), FEV1/FVC (Forced vital capacity) ratio (MD = 6.81, 95% CI: 3.22 to 10.40, P < 0.05), Quality of life: St. George's Respiratory Questionnaire total score (MD = - 9.85, 95%CI: - 13.13 to - 6.56, P < 0.05), and Chronic Obstructive Pulmonary Disease Assessment Test score (MD = - 2.29, 95%CI: - 3.27, - 1.30, P < 0.05). CONCLUSION: Evidence from meta-analysis suggested that Liuzijue exercise could improve dyspnea, exercise endurance, lung function, and quality of life for stable COPD patients. However, owing to the methodological bias and the placebo effect of Liuzijue exercise, there is a need for further research to confirm these findings. TRIAL REGISTRATION: PROSPERO (ID: CRD42019130973). SN - 2662-7671 UR - https://www.unboundmedicine.com/medline/citation/33054800/A_systematic_review_and_meta_analysis_of_Liuzijue_in_stable_patients_with_chronic_obstructive_pulmonary_disease_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/33054800/ DB - PRIME DP - Unbound Medicine ER -