Tags

Type your tag names separated by a space and hit enter

The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials.
Sci Rep. 2020 10 14; 10(1):17234.SR

Abstract

The previous meta-analysis of clinical trials revealed a beneficial effect of vitamin E supplementation on serum C-reactive protein (CRP) concentrations; however, it is unknown whether this vitamin has the same influence on other inflammatory biomarkers. Also, several clinical trials have been published since the release of earlier meta-analysis. Therefore, we aimed to conduct a comprehensive meta-analysis to summarize current evidence on the effects of vitamin E supplementation on inflammatory biomarkers in adults. We searched the online databases using relevant keywords up to November 2019. Randomized clinical trials (RCTs) investigating the effect of vitamin E, compared with the placebo, on serum concentrations of inflammatory cytokines were included. Overall, we included 33 trials with a total sample size of 2102 individuals, aged from 20 to 70 years. Based on 36 effect sizes from 26 RCTs on serum concentrations of CRP, we found a significant reduction following supplementation with vitamin E (- 0.52, 95% CI - 0.80, - 0.23 mg/L, P < 0.001). Although the overall effect of vitamin E supplementation on serum concentrations of interleukin-6 (IL-6) was not significant, a significant reduction in this cytokine was seen in studies that used α-tocopherol and those trials that included patients with disorders related to insulin resistance. Moreover, we found a significant reducing effect of vitamin E supplementation on tumor necrosis factor-α (TNF-α) concentrations at high dosages of vitamin E; such that based on dose-response analysis, serum TNF-α concentrations were reduced significantly at the dosages of ≥ 700 mg/day vitamin E (Pnon-linearity = 0.001). Considering different chemical forms of vitamin E, α-tocopherol, unlike other forms, had a reducing effect on serum levels of CRP and IL-6. In conclusion, our findings revealed a beneficial effect of vitamin E supplementation, particularly in the form of α-tocopherol, on subclinical inflammation in adults. Future high-quality RCTs should be conducted to translate this anti-inflammatory effect of vitamin E to the clinical setting.

Authors+Show Affiliations

Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.Nutritional Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. Department of Clinical Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Clinical Nutrition, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. mdalizadeh@tbzmed.ac.ir. Nutrition Research Center, Faculty of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran. mdalizadeh@tbzmed.ac.ir.Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran. Gerash University of Medical Sciences, Gerash, Iran.Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran. omidsadeghi69@yahoo.com. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran. omidsadeghi69@yahoo.com.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

33057114

Citation

Asbaghi, Omid, et al. "The Effect of Vitamin E Supplementation On Selected Inflammatory Biomarkers in Adults: a Systematic Review and Meta-analysis of Randomized Clinical Trials." Scientific Reports, vol. 10, no. 1, 2020, p. 17234.
Asbaghi O, Sadeghian M, Nazarian B, et al. The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials. Sci Rep. 2020;10(1):17234.
Asbaghi, O., Sadeghian, M., Nazarian, B., Sarreshtedari, M., Mozaffari-Khosravi, H., Maleki, V., Alizadeh, M., Shokri, A., & Sadeghi, O. (2020). The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials. Scientific Reports, 10(1), 17234. https://doi.org/10.1038/s41598-020-73741-6
Asbaghi O, et al. The Effect of Vitamin E Supplementation On Selected Inflammatory Biomarkers in Adults: a Systematic Review and Meta-analysis of Randomized Clinical Trials. Sci Rep. 2020 10 14;10(1):17234. PubMed PMID: 33057114.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials. AU - Asbaghi,Omid, AU - Sadeghian,Mehdi, AU - Nazarian,Behzad, AU - Sarreshtedari,Mehrnoosh, AU - Mozaffari-Khosravi,Hassan, AU - Maleki,Vahid, AU - Alizadeh,Mohammad, AU - Shokri,Azad, AU - Sadeghi,Omid, Y1 - 2020/10/14/ PY - 2020/01/21/received PY - 2020/09/17/accepted PY - 2020/10/15/entrez PY - 2020/10/16/pubmed PY - 2021/3/10/medline SP - 17234 EP - 17234 JF - Scientific reports JO - Sci Rep VL - 10 IS - 1 N2 - The previous meta-analysis of clinical trials revealed a beneficial effect of vitamin E supplementation on serum C-reactive protein (CRP) concentrations; however, it is unknown whether this vitamin has the same influence on other inflammatory biomarkers. Also, several clinical trials have been published since the release of earlier meta-analysis. Therefore, we aimed to conduct a comprehensive meta-analysis to summarize current evidence on the effects of vitamin E supplementation on inflammatory biomarkers in adults. We searched the online databases using relevant keywords up to November 2019. Randomized clinical trials (RCTs) investigating the effect of vitamin E, compared with the placebo, on serum concentrations of inflammatory cytokines were included. Overall, we included 33 trials with a total sample size of 2102 individuals, aged from 20 to 70 years. Based on 36 effect sizes from 26 RCTs on serum concentrations of CRP, we found a significant reduction following supplementation with vitamin E (- 0.52, 95% CI - 0.80, - 0.23 mg/L, P < 0.001). Although the overall effect of vitamin E supplementation on serum concentrations of interleukin-6 (IL-6) was not significant, a significant reduction in this cytokine was seen in studies that used α-tocopherol and those trials that included patients with disorders related to insulin resistance. Moreover, we found a significant reducing effect of vitamin E supplementation on tumor necrosis factor-α (TNF-α) concentrations at high dosages of vitamin E; such that based on dose-response analysis, serum TNF-α concentrations were reduced significantly at the dosages of ≥ 700 mg/day vitamin E (Pnon-linearity = 0.001). Considering different chemical forms of vitamin E, α-tocopherol, unlike other forms, had a reducing effect on serum levels of CRP and IL-6. In conclusion, our findings revealed a beneficial effect of vitamin E supplementation, particularly in the form of α-tocopherol, on subclinical inflammation in adults. Future high-quality RCTs should be conducted to translate this anti-inflammatory effect of vitamin E to the clinical setting. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/33057114/The_effect_of_vitamin_E_supplementation_on_selected_inflammatory_biomarkers_in_adults:_a_systematic_review_and_meta_analysis_of_randomized_clinical_trials_ DB - PRIME DP - Unbound Medicine ER -