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Post lockdown COVID-19 seroprevalence and circulation at the time of delivery, France.
PLoS One. 2020; 15(10):e0240782.Plos

Abstract

BACKGROUND

To fight the COVID-19 pandemic, lockdown has been decreed in many countries worldwide. The impact of pregnancy as a severity risk factor is still debated, but strict lockdown measures have been recommended for pregnant women.

OBJECTIVES

To evaluate the impact of the COVID-19 pandemic and lockdown on the seroprevalence and circulation of SARS-CoV-2 in a maternity ward in an area that has been significantly affected by the virus.

STUDY DESIGN

Prospective study at the Antoine Béclère Hospital maternity ward (Paris area, France) from May 4 (one week before the end of lockdown) to May 31, 2020 (three weeks after the end of lockdown). All patients admitted to the delivery room during this period were offered a SARS-CoV-2 serology test as well concomitant SARS-CoV-2 RT-PCR on one nasopharyngeal sample.

RESULTS

A total of 249 women were included. Seroprevalence of SARS-CoV-2 was 8%. The RT-PCR positive rate was 0.5%. 47.4% of the SARS-CoV-2-IgG-positive pregnant women never experienced any symptoms. A history of symptoms during the epidemic, such as fever (15.8%), myalgia (36.8%) and anosmia (31.6%), was suggestive of previous infection.

CONCLUSIONS

Three weeks after the end of French lockdown, SARS-CoV-2 infections were scarce in our region. A very high proportion of SARS-CoV-2-IgG-negative pregnant women, which is comparable to that of the general population, must be taken into consideration in the event of a resurgence of the pandemic. The traces of a past active circulation of the virus in this fragile population during the spring wave should encourage public health authorities to take specific measures for this independent at-risk group, in order to reduce viral circulation in pregnant patients.

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Authors+Show Affiliations

Mattern J
Division of Obstetrics and Gynecology, Antoine Béclère Hospital, Paris Saclay University, AP-HP, Clamart, France.
Vauloup-Fellous C
Division of Virology, Paul Brousse Hospital, Paris Saclay University, AP-HP, INSERM U1193, Villejuif, France.
Zakaria H
Division of Obstetrics and Gynecology, Antoine Béclère Hospital, Paris Saclay University, AP-HP, Clamart, France.
Benachi A
Division of Obstetrics and Gynecology, Antoine Béclère Hospital, Paris Saclay University, AP-HP, Clamart, France.
Carrara J
Division of Obstetrics and Gynecology, Antoine Béclère Hospital, Paris Saclay University, AP-HP, Clamart, France.
Letourneau A
Division of Obstetrics and Gynecology, Antoine Béclère Hospital, Paris Saclay University, AP-HP, Clamart, France.
Bourgeois-Nicolaos N
Division of Microbiology, Antoine Béclère Hospital, Paris Saclay University, AP-HP, Clamart, France.
De Luca D
Division of Pediatrics and Neonatal Critical Care, Antoine Bécleère Hospital, Paris Saclay University, AP-HP, Clamart, France.
Doucet-Populaire F
Division of Microbiology, Antoine Béclère Hospital, Paris Saclay University, AP-HP, Clamart, France.
Vivanti AJ
Division of Obstetrics and Gynecology, Antoine Béclère Hospital, Paris Saclay University, AP-HP, Clamart, France.

MeSH

AdultAntibodies, ViralBetacoronavirusCOVID-19COVID-19 TestingCOVID-19 VaccinesClinical Laboratory TechniquesCoronavirus InfectionsFemaleHumansImmunoglobulin GPandemicsParisParturitionPneumonia, ViralPregnancyPregnancy Complications, InfectiousProspective StudiesQuarantineReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionSARS-CoV-2Seroepidemiologic StudiesSerologic Tests

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33057392

Citation

Mattern, Jérémie, et al. "Post Lockdown COVID-19 Seroprevalence and Circulation at the Time of Delivery, France." PloS One, vol. 15, no. 10, 2020, pp. e0240782.
Mattern J, Vauloup-Fellous C, Zakaria H, et al. Post lockdown COVID-19 seroprevalence and circulation at the time of delivery, France. PLoS One. 2020;15(10):e0240782.
Mattern, J., Vauloup-Fellous, C., Zakaria, H., Benachi, A., Carrara, J., Letourneau, A., Bourgeois-Nicolaos, N., De Luca, D., Doucet-Populaire, F., & Vivanti, A. J. (2020). Post lockdown COVID-19 seroprevalence and circulation at the time of delivery, France. PloS One, 15(10), e0240782. https://doi.org/10.1371/journal.pone.0240782
Mattern J, et al. Post Lockdown COVID-19 Seroprevalence and Circulation at the Time of Delivery, France. PLoS One. 2020;15(10):e0240782. PubMed PMID: 33057392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Post lockdown COVID-19 seroprevalence and circulation at the time of delivery, France. AU - Mattern,Jérémie, AU - Vauloup-Fellous,Christelle, AU - Zakaria,Hoda, AU - Benachi,Alexandra, AU - Carrara,Julie, AU - Letourneau,Alexandra, AU - Bourgeois-Nicolaos,Nadège, AU - De Luca,Daniele, AU - Doucet-Populaire,Florence, AU - Vivanti,Alexandre J, Y1 - 2020/10/15/ PY - 2020/07/07/received PY - 2020/10/02/accepted PY - 2020/10/15/entrez PY - 2020/10/16/pubmed PY - 2020/11/3/medline SP - e0240782 EP - e0240782 JF - PloS one JO - PLoS One VL - 15 IS - 10 N2 - BACKGROUND: To fight the COVID-19 pandemic, lockdown has been decreed in many countries worldwide. The impact of pregnancy as a severity risk factor is still debated, but strict lockdown measures have been recommended for pregnant women. OBJECTIVES: To evaluate the impact of the COVID-19 pandemic and lockdown on the seroprevalence and circulation of SARS-CoV-2 in a maternity ward in an area that has been significantly affected by the virus. STUDY DESIGN: Prospective study at the Antoine Béclère Hospital maternity ward (Paris area, France) from May 4 (one week before the end of lockdown) to May 31, 2020 (three weeks after the end of lockdown). All patients admitted to the delivery room during this period were offered a SARS-CoV-2 serology test as well concomitant SARS-CoV-2 RT-PCR on one nasopharyngeal sample. RESULTS: A total of 249 women were included. Seroprevalence of SARS-CoV-2 was 8%. The RT-PCR positive rate was 0.5%. 47.4% of the SARS-CoV-2-IgG-positive pregnant women never experienced any symptoms. A history of symptoms during the epidemic, such as fever (15.8%), myalgia (36.8%) and anosmia (31.6%), was suggestive of previous infection. CONCLUSIONS: Three weeks after the end of French lockdown, SARS-CoV-2 infections were scarce in our region. A very high proportion of SARS-CoV-2-IgG-negative pregnant women, which is comparable to that of the general population, must be taken into consideration in the event of a resurgence of the pandemic. The traces of a past active circulation of the virus in this fragile population during the spring wave should encourage public health authorities to take specific measures for this independent at-risk group, in order to reduce viral circulation in pregnant patients. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/33057392/Post_lockdown_COVID_19_seroprevalence_and_circulation_at_the_time_of_delivery_France_ DB - PRIME DP - Unbound Medicine ER -