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Glycoprotein calcium oxalate crystal growth inhibitor in urine.
Miner Electrolyte Metab. 1987; 13(4):267-72.ME

Abstract

Urine is normally supersaturated with respect to calcium oxalate. Inhibitors of the growth and aggregation of calcium oxalate crystals are present in urine and probably protect against calcium stone formation. These inhibitors are deficient in stone formers. The major inhibitor of calcium oxalate crystal growth is a non-dialyzable, anionic macromolecule. An acidic glycoprotein has been isolated from urine and human kidney tissue culture medium which inhibits calcium oxalate crystal growth in vitro. This glycoprotein crystallization inhibitor has a molecular weight of 14,000 daltons and contains 2-3 residues of gamma-carboxyglutamic acid. The dissociation constant for the calcium oxalate crystal-inhibitor complex is about 10(-7) M. The glycoprotein isolated from the urine of calcium stone formers has a decreased affinity for crystal surface, and a proportionally weaker inhibitory activity; it also lacks gamma-carboxyglutamic acid.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

3306319

Citation

Worcester, E M., et al. "Glycoprotein Calcium Oxalate Crystal Growth Inhibitor in Urine." Mineral and Electrolyte Metabolism, vol. 13, no. 4, 1987, pp. 267-72.
Worcester EM, Nakagawa Y, Coe FL. Glycoprotein calcium oxalate crystal growth inhibitor in urine. Miner Electrolyte Metab. 1987;13(4):267-72.
Worcester, E. M., Nakagawa, Y., & Coe, F. L. (1987). Glycoprotein calcium oxalate crystal growth inhibitor in urine. Mineral and Electrolyte Metabolism, 13(4), 267-72.
Worcester EM, Nakagawa Y, Coe FL. Glycoprotein Calcium Oxalate Crystal Growth Inhibitor in Urine. Miner Electrolyte Metab. 1987;13(4):267-72. PubMed PMID: 3306319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycoprotein calcium oxalate crystal growth inhibitor in urine. AU - Worcester,E M, AU - Nakagawa,Y, AU - Coe,F L, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 267 EP - 72 JF - Mineral and electrolyte metabolism JO - Miner Electrolyte Metab VL - 13 IS - 4 N2 - Urine is normally supersaturated with respect to calcium oxalate. Inhibitors of the growth and aggregation of calcium oxalate crystals are present in urine and probably protect against calcium stone formation. These inhibitors are deficient in stone formers. The major inhibitor of calcium oxalate crystal growth is a non-dialyzable, anionic macromolecule. An acidic glycoprotein has been isolated from urine and human kidney tissue culture medium which inhibits calcium oxalate crystal growth in vitro. This glycoprotein crystallization inhibitor has a molecular weight of 14,000 daltons and contains 2-3 residues of gamma-carboxyglutamic acid. The dissociation constant for the calcium oxalate crystal-inhibitor complex is about 10(-7) M. The glycoprotein isolated from the urine of calcium stone formers has a decreased affinity for crystal surface, and a proportionally weaker inhibitory activity; it also lacks gamma-carboxyglutamic acid. SN - 0378-0392 UR - https://www.unboundmedicine.com/medline/citation/3306319/Glycoprotein_calcium_oxalate_crystal_growth_inhibitor_in_urine_ DB - PRIME DP - Unbound Medicine ER -
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