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Genes affecting the extension of chronological lifespan in Schizosaccharomyces pombe (fission yeast).
Mol Microbiol. 2021 04; 115(4):623-642.MM

Abstract

So far, more than 70 genes involved in the chronological lifespan (CLS) of Schizosaccharomyces pombe (fission yeast) have been reported. In this mini-review, we arrange and summarize these genes based on the reported genetic interactions between them and the physical interactions between their products. We describe the signal transduction pathways that affect CLS in S. pombe: target of rapamycin complex 1, cAMP-dependent protein kinase, Sty1, and Pmk1 pathways have important functions in the regulation of CLS extension. Furthermore, the Php transcription complex, Ecl1 family proteins, cyclin Clg1, and the cyclin-dependent kinase Pef1 are important for the regulation of CLS extension in S. pombe. Most of the known genes involved in CLS extension are related to these pathways and genes. In this review, we focus on the individual genes regulating CLS extension in S. pombe and discuss the interactions among them.

Authors+Show Affiliations

Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan.Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan.Laboratory of Molecular Microbiology, Department of Basic Medicinal Sciences, Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

33064911

Citation

Ohtsuka, Hokuto, et al. "Genes Affecting the Extension of Chronological Lifespan in Schizosaccharomyces Pombe (fission Yeast)." Molecular Microbiology, vol. 115, no. 4, 2021, pp. 623-642.
Ohtsuka H, Shimasaki T, Aiba H. Genes affecting the extension of chronological lifespan in Schizosaccharomyces pombe (fission yeast). Mol Microbiol. 2021;115(4):623-642.
Ohtsuka, H., Shimasaki, T., & Aiba, H. (2021). Genes affecting the extension of chronological lifespan in Schizosaccharomyces pombe (fission yeast). Molecular Microbiology, 115(4), 623-642. https://doi.org/10.1111/mmi.14627
Ohtsuka H, Shimasaki T, Aiba H. Genes Affecting the Extension of Chronological Lifespan in Schizosaccharomyces Pombe (fission Yeast). Mol Microbiol. 2021;115(4):623-642. PubMed PMID: 33064911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genes affecting the extension of chronological lifespan in Schizosaccharomyces pombe (fission yeast). AU - Ohtsuka,Hokuto, AU - Shimasaki,Takafumi, AU - Aiba,Hirofumi, Y1 - 2020/11/03/ PY - 2020/09/17/revised PY - 2020/08/03/received PY - 2020/10/11/accepted PY - 2020/10/17/pubmed PY - 2020/10/17/medline PY - 2020/10/16/entrez KW - Schizosaccharomyces pombe KW - chronological lifespan KW - fission yeast KW - longevity KW - signal transduction KW - stationary phase SP - 623 EP - 642 JF - Molecular microbiology JO - Mol Microbiol VL - 115 IS - 4 N2 - So far, more than 70 genes involved in the chronological lifespan (CLS) of Schizosaccharomyces pombe (fission yeast) have been reported. In this mini-review, we arrange and summarize these genes based on the reported genetic interactions between them and the physical interactions between their products. We describe the signal transduction pathways that affect CLS in S. pombe: target of rapamycin complex 1, cAMP-dependent protein kinase, Sty1, and Pmk1 pathways have important functions in the regulation of CLS extension. Furthermore, the Php transcription complex, Ecl1 family proteins, cyclin Clg1, and the cyclin-dependent kinase Pef1 are important for the regulation of CLS extension in S. pombe. Most of the known genes involved in CLS extension are related to these pathways and genes. In this review, we focus on the individual genes regulating CLS extension in S. pombe and discuss the interactions among them. SN - 1365-2958 UR - https://www.unboundmedicine.com/medline/citation/33064911/Genes_affecting_the_extension_of_chronological_lifespan_in_Schizosaccharomyces_pombe__fission_yeast__ L2 - https://doi.org/10.1111/mmi.14627 DB - PRIME DP - Unbound Medicine ER -