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Antiulcer Activity of Steamed Ginger Extract against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats.
Molecules. 2020 Oct 13; 25(20)M

Abstract

Ginger (Zingiber officianale), the most widely consumed species, is traditionally used as a folk medicine to treat some inflammatory diseases in China and Korea. However, the functional activity of steamed ginger extract on gastric ulcers has not been previously explored. The present study aimed to investigate antiulcer activity of steamed ginger extract (GGE03) against ethanol (EtOH)/HCl-induced gastric ulcers in a rat model. GGE03 (100 mg/kg) was orally administered for 14 days to rats before oral intubation of an EtOH/HCl mixture to induce gastric damage. Pretreatment with GGE03 markedly protected the formation of microscopic pathological damage in the gastric mucosa. Further, administration of GGE03 significantly increased mucosal total nitrate/nitrite production in gastric tissues, and elevated total GSH content, catalase activity and superoxide dismutase (SOD) expression as well as decreasing lipid peroxidation and myeloperoxidase (MPO) activity. Underlying protective mechanisms were examined by assessing inflammation-related genes, including nuclear factor-κB (NF-κB), prostaglandin E2 (PGE2), and pro-inflammatory cytokines levels. GGE03 administration significantly reduced the expression of NF-κB and pro-inflammatory cytokines. Our findings suggest that GGE03 possesses antiulcer activity by attenuating oxidative stress and inflammatory responses.

Authors+Show Affiliations

School of Pharmacy, Sungkyunkwan University, Seobu-ro, Suwon 16419, Gyeonggi-do, Korea.School of Pharmacy, Sungkyunkwan University, Seobu-ro, Suwon 16419, Gyeonggi-do, Korea.School of Pharmacy, Sungkyunkwan University, Seobu-ro, Suwon 16419, Gyeonggi-do, Korea.Department of Oriental Medicine Biotechnology, Graduate School of Biotechnology, Kyung Hee University, Yongin 17104, Gyeonggi-do, Korea.School of Pharmacy, Sungkyunkwan University, Seobu-ro, Suwon 16419, Gyeonggi-do, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33066164

Citation

Shin, Jun-Kyu, et al. "Antiulcer Activity of Steamed Ginger Extract Against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats." Molecules (Basel, Switzerland), vol. 25, no. 20, 2020.
Shin JK, Park JH, Kim KS, et al. Antiulcer Activity of Steamed Ginger Extract against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats. Molecules. 2020;25(20).
Shin, J. K., Park, J. H., Kim, K. S., Kang, T. H., & Kim, H. S. (2020). Antiulcer Activity of Steamed Ginger Extract against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats. Molecules (Basel, Switzerland), 25(20). https://doi.org/10.3390/molecules25204663
Shin JK, et al. Antiulcer Activity of Steamed Ginger Extract Against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats. Molecules. 2020 Oct 13;25(20) PubMed PMID: 33066164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiulcer Activity of Steamed Ginger Extract against Ethanol/HCl-Induced Gastric Mucosal Injury in Rats. AU - Shin,Jun-Kyu, AU - Park,Jae Hyeon, AU - Kim,Kyeong Seok, AU - Kang,Tong Ho, AU - Kim,Hyung Sik, Y1 - 2020/10/13/ PY - 2020/09/13/received PY - 2020/10/12/revised PY - 2020/10/12/accepted PY - 2020/10/17/entrez PY - 2020/10/18/pubmed PY - 2021/4/30/medline KW - Zingiber officianale KW - antiulcer KW - oxidative stress KW - pro-inflammatory cytokines KW - steamed ginger extract JF - Molecules (Basel, Switzerland) JO - Molecules VL - 25 IS - 20 N2 - Ginger (Zingiber officianale), the most widely consumed species, is traditionally used as a folk medicine to treat some inflammatory diseases in China and Korea. However, the functional activity of steamed ginger extract on gastric ulcers has not been previously explored. The present study aimed to investigate antiulcer activity of steamed ginger extract (GGE03) against ethanol (EtOH)/HCl-induced gastric ulcers in a rat model. GGE03 (100 mg/kg) was orally administered for 14 days to rats before oral intubation of an EtOH/HCl mixture to induce gastric damage. Pretreatment with GGE03 markedly protected the formation of microscopic pathological damage in the gastric mucosa. Further, administration of GGE03 significantly increased mucosal total nitrate/nitrite production in gastric tissues, and elevated total GSH content, catalase activity and superoxide dismutase (SOD) expression as well as decreasing lipid peroxidation and myeloperoxidase (MPO) activity. Underlying protective mechanisms were examined by assessing inflammation-related genes, including nuclear factor-κB (NF-κB), prostaglandin E2 (PGE2), and pro-inflammatory cytokines levels. GGE03 administration significantly reduced the expression of NF-κB and pro-inflammatory cytokines. Our findings suggest that GGE03 possesses antiulcer activity by attenuating oxidative stress and inflammatory responses. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/33066164/Antiulcer_Activity_of_Steamed_Ginger_Extract_against_Ethanol/HCl_Induced_Gastric_Mucosal_Injury_in_Rats_ L2 - https://www.mdpi.com/resolver?pii=molecules25204663 DB - PRIME DP - Unbound Medicine ER -