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Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis.
Cells. 2020 10 14; 9(10)C

Abstract

Ciguatera fish poisoning (CFP), the most prevalent seafood poisoning worldwide, is caused by the consumption of tropical and subtropical fish contaminated with potent neurotoxins called ciguatoxins (CTXs). Ciguatera is a complex clinical syndrome in which peripheral neurological signs predominate in the acute phase of the intoxication but also persist or reoccur long afterward. Their recognition is of particular importance in establishing the diagnosis, which is clinically-based and can be a challenge for physicians unfamiliar with CFP. To date, no specific treatment exists. Physiopathologically, the primary targets of CTXs are well identified, as are the secondary events that may contribute to CFP symptomatology. This review describes the clinical features, focusing on the sensory disturbances, and then reports on the neuronal targets and effects of CTXs, as well as the neurophysiological and histological studies that have contributed to existing knowledge of CFP neuropathophysiology at the molecular, neurocellular and nerve levels.

Authors+Show Affiliations

University of Brest, School of Medicine, Laboratoire Interactions Epithéliums-Neurones (Univ Brest, LIEN), F-29200 Brest, France.University of Brest, School of Medicine, Laboratoire Interactions Epithéliums-Neurones (Univ Brest, LIEN), F-29200 Brest, France. Department of Dermatology, University Hospital of Brest, F-29200 Brest, France.University of Brest, School of Medicine, INSERM U1227, Lymphocytes B et auto-immunité, F-29200 Brest, France.University of Brest, School of Medicine, Laboratoire Interactions Epithéliums-Neurones (Univ Brest, LIEN), F-29200 Brest, France. Department of Dermatology, University Hospital of Brest, F-29200 Brest, France.University of Brest, School of Medicine, Laboratoire Interactions Epithéliums-Neurones (Univ Brest, LIEN), F-29200 Brest, France.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33066435

Citation

L'Herondelle, Killian, et al. "Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis." Cells, vol. 9, no. 10, 2020.
L'Herondelle K, Talagas M, Mignen O, et al. Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis. Cells. 2020;9(10).
L'Herondelle, K., Talagas, M., Mignen, O., Misery, L., & Le Garrec, R. (2020). Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis. Cells, 9(10). https://doi.org/10.3390/cells9102291
L'Herondelle K, et al. Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis. Cells. 2020 10 14;9(10) PubMed PMID: 33066435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurological Disturbances of Ciguatera Poisoning: Clinical Features and Pathophysiological Basis. AU - L'Herondelle,Killian, AU - Talagas,Matthieu, AU - Mignen,Olivier, AU - Misery,Laurent, AU - Le Garrec,Raphaele, Y1 - 2020/10/14/ PY - 2020/08/31/received PY - 2020/10/07/revised PY - 2020/10/12/accepted PY - 2020/10/17/entrez PY - 2020/10/18/pubmed PY - 2020/10/18/medline KW - ciguatera KW - ciguatoxin KW - neurological KW - pathophysiology KW - sensory JF - Cells JO - Cells VL - 9 IS - 10 N2 - Ciguatera fish poisoning (CFP), the most prevalent seafood poisoning worldwide, is caused by the consumption of tropical and subtropical fish contaminated with potent neurotoxins called ciguatoxins (CTXs). Ciguatera is a complex clinical syndrome in which peripheral neurological signs predominate in the acute phase of the intoxication but also persist or reoccur long afterward. Their recognition is of particular importance in establishing the diagnosis, which is clinically-based and can be a challenge for physicians unfamiliar with CFP. To date, no specific treatment exists. Physiopathologically, the primary targets of CTXs are well identified, as are the secondary events that may contribute to CFP symptomatology. This review describes the clinical features, focusing on the sensory disturbances, and then reports on the neuronal targets and effects of CTXs, as well as the neurophysiological and histological studies that have contributed to existing knowledge of CFP neuropathophysiology at the molecular, neurocellular and nerve levels. SN - 2073-4409 UR - https://www.unboundmedicine.com/medline/citation/33066435/Neurological_Disturbances_of_Ciguatera_Poisoning:_Clinical_Features_and_Pathophysiological_Basis_ L2 - https://www.mdpi.com/resolver?pii=cells9102291 DB - PRIME DP - Unbound Medicine ER -