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Antioxidant compounds from Banisteriopsis argyrophylla leaves as α-amylase, α-glucosidase, lipase, and glycation inhibitors.
Bioorg Chem. 2020 12; 105:104335.BC

Abstract

Banisteriopsis argyrophylla belongs to the Malpighiaceae family, which is a species from Cerrado, also known as "cipó-prata" or "cipó-folha-de-prata." Several species of this family present biological potential. This work reports the chemical identification of the ethanol extract (EE) and its fractions from B. argyrophylla leaves and shows the analysis of the antioxidant activity and inhibitory effects on activities of α-amylase, α-glucosidase and lipase, and non-enzymatic glycation. The ethyl acetate fraction (EAF) and n-butanol fraction (BF) showed antioxidant activity, with IC50 values of 4.1 ± 0.1 and 4.8 ± 0.1 μg mL-1, respectively, by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, and IC50 values of 6046.3 ± 174.2 and 6264.2 ± 32.2 µmol Trolox eq g-1 by the oxygen radical absorbance capacity (ORAC) method. Furthermore, the DPPH method with these fractions presented electroactive species with antioxidant potential, as shown by the differential pulse voltammetry (DPV) method. The inhibitory effects of the EAF and BF were demonstrated by the following results: IC50 of 5.1 ± 0.3 and 2.5 ± 0.2 μg mL-1 for α-amylase, IC50 of 1093.5 ± 26.0 and 1250.8 ± 21.9 μg mL-1 for α-glucosidase, IC50 of 8.3 ± 4.1 and 4.4 ± 1.0 μg mL-1 for lipase, and IC50 of 1.3 ± 0.1 and 0.9 ± 0.1 μg mL-1 for glycation. Some bioactive compounds were identified by (-)-ESI-MS/MS, such as catechin, procyanidins, glycosylated flavonoids, kaempferol, and megastigmane glucosides. The antidiabetic activity of B.argyrophylla has been reported for the first time.

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Authors+Show Affiliations

Institute of Chemistry, Federal University of Uberlândia, Av. João Naves de Ávila, 2121. Campus Santa Mônica, Uberlândia-MG, CEP 38400-902, Brazil.

Institute of Biotechnology, Federal University of Uberlândia, Av. Pará, 1720. Campus Umuarama, Uberlândia-MG, CEP 38400-902, Brazil.

Institute of Chemistry, Federal University of Uberlândia, Av. João Naves de Ávila, 2121. Campus Santa Mônica, Uberlândia-MG, CEP 38400-902, Brazil.

Institute of Chemistry, Federal University of Uberlândia, Av. João Naves de Ávila, 2121. Campus Santa Mônica, Uberlândia-MG, CEP 38400-902, Brazil.

Institute of Chemistry, Federal University of Uberlândia, Av. João Naves de Ávila, 2121. Campus Santa Mônica, Uberlândia-MG, CEP 38400-902, Brazil.

Institute of Biotechnology, Federal University of Uberlândia, Av. Pará, 1720. Campus Umuarama, Uberlândia-MG, CEP 38400-902, Brazil.

Institute of Biotechnology, Federal University of Uberlândia, Av. Pará, 1720. Campus Umuarama, Uberlândia-MG, CEP 38400-902, Brazil.

Institute of Chemistry, Federal University of Uberlândia, Av. João Naves de Ávila, 2121. Campus Santa Mônica, Uberlândia-MG, CEP 38400-902, Brazil.

Institute of Biotechnology, Federal University of Uberlândia, Av. Pará, 1720. Campus Umuarama, Uberlândia-MG, CEP 38400-902, Brazil.

Institute of Chemistry, Federal University of Uberlândia, Av. João Naves de Ávila, 2121. Campus Santa Mônica, Uberlândia-MG, CEP 38400-902, Brazil. Electronic address: alberto@ufu.br.

MeSH

AntioxidantsBanisteriopsisCatechinCyclohexanonesDrug Evaluation, PreclinicalEnzyme InhibitorsFlavonoidsGlucosidesGlycosylationHumansHypoglycemic AgentsKaempferolsLipaseNorisoprenoidsPlant ExtractsPlant LeavesProanthocyanidinsalpha-Amylasesalpha-Glucosidases

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33074116

Citation

Quaresma, Daiane M O., et al. "Antioxidant Compounds From Banisteriopsis Argyrophylla Leaves as Α-amylase, Α-glucosidase, Lipase, and Glycation Inhibitors." Bioorganic Chemistry, vol. 105, 2020, p. 104335.

Quaresma DMO, Justino AB, Sousa RMF, et al. Antioxidant compounds from Banisteriopsis argyrophylla leaves as α-amylase, α-glucosidase, lipase, and glycation inhibitors. Bioorg Chem. 2020;105:104335.

Quaresma, D. M. O., Justino, A. B., Sousa, R. M. F., Munoz, R. A. A., de Aquino, F. J. T., Martins, M. M., Goulart, L. R., Pivatto, M., Espindola, F. S., & de Oliveira, A. (2020). Antioxidant compounds from Banisteriopsis argyrophylla leaves as α-amylase, α-glucosidase, lipase, and glycation inhibitors. Bioorganic Chemistry, 105, 104335. https://doi.org/10.1016/j.bioorg.2020.104335

Quaresma DMO, et al. Antioxidant Compounds From Banisteriopsis Argyrophylla Leaves as Α-amylase, Α-glucosidase, Lipase, and Glycation Inhibitors. Bioorg Chem. 2020;105:104335. PubMed PMID: 33074116.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Antioxidant compounds from Banisteriopsis argyrophylla leaves as α-amylase, α-glucosidase, lipase, and glycation inhibitors. AU - Quaresma,Daiane M O, AU - Justino,Allisson B, AU - Sousa,Raquel M F, AU - Munoz,Rodrigo A A, AU - de Aquino,Francisco J T, AU - Martins,Mário M, AU - Goulart,Luiz R, AU - Pivatto,Marcos, AU - Espindola,Foued S, AU - de Oliveira,Alberto, Y1 - 2020/10/06/ PY - 2020/06/04/received PY - 2020/08/27/revised PY - 2020/09/29/accepted PY - 2020/10/20/pubmed PY - 2021/3/20/medline PY - 2020/10/19/entrez KW - Banisteriopsis argyrophylla KW - DPPH KW - Electroactivity KW - Flavonoids, diabetic complications KW - ORAC KW - Voltammetric SP - 104335 EP - 104335 JF - Bioorganic chemistry JO - Bioorg Chem VL - 105 N2 - Banisteriopsis argyrophylla belongs to the Malpighiaceae family, which is a species from Cerrado, also known as "cipó-prata" or "cipó-folha-de-prata." Several species of this family present biological potential. This work reports the chemical identification of the ethanol extract (EE) and its fractions from B. argyrophylla leaves and shows the analysis of the antioxidant activity and inhibitory effects on activities of α-amylase, α-glucosidase and lipase, and non-enzymatic glycation. The ethyl acetate fraction (EAF) and n-butanol fraction (BF) showed antioxidant activity, with IC50 values of 4.1 ± 0.1 and 4.8 ± 0.1 μg mL-1, respectively, by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, and IC50 values of 6046.3 ± 174.2 and 6264.2 ± 32.2 µmol Trolox eq g-1 by the oxygen radical absorbance capacity (ORAC) method. Furthermore, the DPPH method with these fractions presented electroactive species with antioxidant potential, as shown by the differential pulse voltammetry (DPV) method. The inhibitory effects of the EAF and BF were demonstrated by the following results: IC50 of 5.1 ± 0.3 and 2.5 ± 0.2 μg mL-1 for α-amylase, IC50 of 1093.5 ± 26.0 and 1250.8 ± 21.9 μg mL-1 for α-glucosidase, IC50 of 8.3 ± 4.1 and 4.4 ± 1.0 μg mL-1 for lipase, and IC50 of 1.3 ± 0.1 and 0.9 ± 0.1 μg mL-1 for glycation. Some bioactive compounds were identified by (-)-ESI-MS/MS, such as catechin, procyanidins, glycosylated flavonoids, kaempferol, and megastigmane glucosides. The antidiabetic activity of B.argyrophylla has been reported for the first time. SN - 1090-2120 UR - https://www.unboundmedicine.com/medline/citation/33074116/Antioxidant_compounds_from_Banisteriopsis_argyrophylla_leaves_as_α_amylase_α_glucosidase_lipase_and_glycation_inhibitors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0045-2068(20)31633-3 DB - PRIME DP - Unbound Medicine ER -