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Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins.

Abstract

In a double-blind trial patients with atopic eczema received either oral evening primrose oil (EPO) (n = 14) or placebo (n = 11) for 12 weeks. In the EPO group a statistically significant improvement was observed in the overall severity and grade of inflammation and in the percentage of the body surface involved by eczema as well as in dryness and itch. Patients in the placebo group showed a significant reduction in inflammation. The patients receiving EPO showed a significantly greater reduction in inflammation than those receiving placebo. Evening primrose oil caused a significant rise in the amount of dihomogammalinolenic acid in the plasma phospholipid fatty acids. Plasma levels of TXB2, 6-keto-PGF1 alpha and PGE1, and the amount of TXB2 released into serum during clotting were not altered by evening primrose oil.

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  • Authors+Show Affiliations

    ,

    Department of Physiology, University of Turku, Finland.

    , ,

    Source

    The British journal of dermatology 117:1 1987 Jul pg 11-9

    MeSH

    6-Ketoprostaglandin F1 alpha
    Adult
    Alprostadil
    Anti-Inflammatory Agents, Non-Steroidal
    Clinical Trials as Topic
    Dermatitis, Atopic
    Dermatologic Agents
    Double-Blind Method
    Fatty Acids
    Fatty Acids, Essential
    Female
    Humans
    Linoleic Acids
    Male
    Phospholipids
    Plant Oils
    Random Allocation
    Skin
    Thromboxane B2
    gamma-Linolenic Acid

    Pub Type(s)

    Clinical Trial
    Controlled Clinical Trial
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    3307886

    Citation

    Schalin-Karrila, M, et al. "Evening Primrose Oil in the Treatment of Atopic Eczema: Effect On Clinical Status, Plasma Phospholipid Fatty Acids and Circulating Blood Prostaglandins." The British Journal of Dermatology, vol. 117, no. 1, 1987, pp. 11-9.
    Schalin-Karrila M, Mattila L, Jansen CT, et al. Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. Br J Dermatol. 1987;117(1):11-9.
    Schalin-Karrila, M., Mattila, L., Jansen, C. T., & Uotila, P. (1987). Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. The British Journal of Dermatology, 117(1), pp. 11-9.
    Schalin-Karrila M, et al. Evening Primrose Oil in the Treatment of Atopic Eczema: Effect On Clinical Status, Plasma Phospholipid Fatty Acids and Circulating Blood Prostaglandins. Br J Dermatol. 1987;117(1):11-9. PubMed PMID: 3307886.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. AU - Schalin-Karrila,M, AU - Mattila,L, AU - Jansen,C T, AU - Uotila,P, PY - 1987/7/1/pubmed PY - 1987/7/1/medline PY - 1987/7/1/entrez SP - 11 EP - 9 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 117 IS - 1 N2 - In a double-blind trial patients with atopic eczema received either oral evening primrose oil (EPO) (n = 14) or placebo (n = 11) for 12 weeks. In the EPO group a statistically significant improvement was observed in the overall severity and grade of inflammation and in the percentage of the body surface involved by eczema as well as in dryness and itch. Patients in the placebo group showed a significant reduction in inflammation. The patients receiving EPO showed a significantly greater reduction in inflammation than those receiving placebo. Evening primrose oil caused a significant rise in the amount of dihomogammalinolenic acid in the plasma phospholipid fatty acids. Plasma levels of TXB2, 6-keto-PGF1 alpha and PGE1, and the amount of TXB2 released into serum during clotting were not altered by evening primrose oil. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/3307886/Evening_primrose_oil_in_the_treatment_of_atopic_eczema:_effect_on_clinical_status_plasma_phospholipid_fatty_acids_and_circulating_blood_prostaglandins_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1987&volume=117&issue=1&spage=11 DB - PRIME DP - Unbound Medicine ER -