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Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins.
Br J Dermatol 1987; 117(1):11-9BJ

Abstract

In a double-blind trial patients with atopic eczema received either oral evening primrose oil (EPO) (n = 14) or placebo (n = 11) for 12 weeks. In the EPO group a statistically significant improvement was observed in the overall severity and grade of inflammation and in the percentage of the body surface involved by eczema as well as in dryness and itch. Patients in the placebo group showed a significant reduction in inflammation. The patients receiving EPO showed a significantly greater reduction in inflammation than those receiving placebo. Evening primrose oil caused a significant rise in the amount of dihomogammalinolenic acid in the plasma phospholipid fatty acids. Plasma levels of TXB2, 6-keto-PGF1 alpha and PGE1, and the amount of TXB2 released into serum during clotting were not altered by evening primrose oil.

Authors+Show Affiliations

Department of Physiology, University of Turku, Finland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3307886

Citation

Schalin-Karrila, M, et al. "Evening Primrose Oil in the Treatment of Atopic Eczema: Effect On Clinical Status, Plasma Phospholipid Fatty Acids and Circulating Blood Prostaglandins." The British Journal of Dermatology, vol. 117, no. 1, 1987, pp. 11-9.
Schalin-Karrila M, Mattila L, Jansen CT, et al. Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. Br J Dermatol. 1987;117(1):11-9.
Schalin-Karrila, M., Mattila, L., Jansen, C. T., & Uotila, P. (1987). Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. The British Journal of Dermatology, 117(1), pp. 11-9.
Schalin-Karrila M, et al. Evening Primrose Oil in the Treatment of Atopic Eczema: Effect On Clinical Status, Plasma Phospholipid Fatty Acids and Circulating Blood Prostaglandins. Br J Dermatol. 1987;117(1):11-9. PubMed PMID: 3307886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. AU - Schalin-Karrila,M, AU - Mattila,L, AU - Jansen,C T, AU - Uotila,P, PY - 1987/7/1/pubmed PY - 1987/7/1/medline PY - 1987/7/1/entrez SP - 11 EP - 9 JF - The British journal of dermatology JO - Br. J. Dermatol. VL - 117 IS - 1 N2 - In a double-blind trial patients with atopic eczema received either oral evening primrose oil (EPO) (n = 14) or placebo (n = 11) for 12 weeks. In the EPO group a statistically significant improvement was observed in the overall severity and grade of inflammation and in the percentage of the body surface involved by eczema as well as in dryness and itch. Patients in the placebo group showed a significant reduction in inflammation. The patients receiving EPO showed a significantly greater reduction in inflammation than those receiving placebo. Evening primrose oil caused a significant rise in the amount of dihomogammalinolenic acid in the plasma phospholipid fatty acids. Plasma levels of TXB2, 6-keto-PGF1 alpha and PGE1, and the amount of TXB2 released into serum during clotting were not altered by evening primrose oil. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/3307886/Evening_primrose_oil_in_the_treatment_of_atopic_eczema:_effect_on_clinical_status_plasma_phospholipid_fatty_acids_and_circulating_blood_prostaglandins_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1987&volume=117&issue=1&spage=11 DB - PRIME DP - Unbound Medicine ER -