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Epidemiological and clinical characteristics of 161 discharged cases with coronavirus disease 2019 in Shanghai, China.
BMC Infect Dis. 2020 Oct 20; 20(1):780.BI

Abstract

BACKGROUND

In December 2019, the outbreak of coronavirus disease 2019 (COVID-19) began in Wuhan, China, and rapidly spread to other regions. We aimed to further describe the epidemiological and clinical characteristics of discharged COVID-19 cases and evaluate the public health interventions.

METHODS

We collected epidemiological and clinical data of all discharged COVID-19 cases as of 17 February 2020 in Shanghai. The key epidemiological distributions were estimated and outcomes were also compared between patients whose illness were before 24 January and those whose illness were after 24 January.

RESULTS

Of 161 discharged COVID-19 cases, the median age was 45 years, and 80 (49.7%) cases were male. All of the cases were categorized as clinical moderate type. The most common initial symptoms were fever (85.7%), cough (41.0%), fatigue (19.3%), muscle ache (17.4%), sputum production (14.9%), and there were six asymptomatic cases. 39 (24.2%) cases got infected in Shanghai, and three of them were second-generation cases of Shanghai native cases. The estimated median of the time from onset to first medical visit, admission, disease confirmation, and discharge for 161 cases was 1.0 day (95% CI, 0.6-1.2), 2.0 days (95% CI, 1.5-2.6), 5.2 days (95% CI, 4.6-5.7), 18.1 days (95% CI, 17.4-18.8), respectively. The estimated median of the time from admission to discharge was 14.0 days (95% CI, 13.3-14.6). The time from onset to first medical visit, admission and disease confirmation were all shortened after the Shanghai's first-level public health emergency response. In Cox regression model, the significant independent covariates for the duration of hospitalization were age, the time from onset to admission and the first-level public health emergency response.

CONCLUSIONS

Local transmission had occurred in Shanghai in late January 2020. The estimated median of the time from onset to discharge of moderate COVID-19 was 18.1 days in Shanghai. Time intervals from onset to first medical visit, admission and disease confirmation were all shortened after the Shanghai's first-level public health emergency response. Age, the first-level public health emergency response and the time from onset to admission were the impact factors for the duration of hospitalization.

Authors+Show Affiliations

Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China.Shanghai Municipal Center for Disease Control and Prevention, No. 1380, West Zhongshan Road, Shanghai, 200336, China. sunxiaodong_scdc@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33081711

Citation

Lin, Sheng, et al. "Epidemiological and Clinical Characteristics of 161 Discharged Cases With Coronavirus Disease 2019 in Shanghai, China." BMC Infectious Diseases, vol. 20, no. 1, 2020, p. 780.
Lin S, Pan H, Wu H, et al. Epidemiological and clinical characteristics of 161 discharged cases with coronavirus disease 2019 in Shanghai, China. BMC Infect Dis. 2020;20(1):780.
Lin, S., Pan, H., Wu, H., Yu, X., Cui, P., Han, R., Jiang, C., Kong, D., Zheng, Y., Gong, X., Xiao, W., Mao, S., Jin, B., Zhu, Y., & Sun, X. (2020). Epidemiological and clinical characteristics of 161 discharged cases with coronavirus disease 2019 in Shanghai, China. BMC Infectious Diseases, 20(1), 780. https://doi.org/10.1186/s12879-020-05493-7
Lin S, et al. Epidemiological and Clinical Characteristics of 161 Discharged Cases With Coronavirus Disease 2019 in Shanghai, China. BMC Infect Dis. 2020 Oct 20;20(1):780. PubMed PMID: 33081711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiological and clinical characteristics of 161 discharged cases with coronavirus disease 2019 in Shanghai, China. AU - Lin,Sheng, AU - Pan,Hao, AU - Wu,Huanyu, AU - Yu,Xiao, AU - Cui,Peng, AU - Han,Ruobing, AU - Jiang,Chenyan, AU - Kong,Dechuan, AU - Zheng,Yaxu, AU - Gong,Xiaohuan, AU - Xiao,Wenjia, AU - Mao,Shenghua, AU - Jin,Bihong, AU - Zhu,Yiyi, AU - Sun,Xiaodong, Y1 - 2020/10/20/ PY - 2020/03/10/received PY - 2020/10/08/accepted PY - 2020/10/21/entrez PY - 2020/10/22/pubmed PY - 2020/10/28/medline KW - Clinical characteristics KW - Coronavirus disease 2019 KW - Epidemiology KW - First-level public health emergency response KW - Transmission SP - 780 EP - 780 JF - BMC infectious diseases JO - BMC Infect Dis VL - 20 IS - 1 N2 - BACKGROUND: In December 2019, the outbreak of coronavirus disease 2019 (COVID-19) began in Wuhan, China, and rapidly spread to other regions. We aimed to further describe the epidemiological and clinical characteristics of discharged COVID-19 cases and evaluate the public health interventions. METHODS: We collected epidemiological and clinical data of all discharged COVID-19 cases as of 17 February 2020 in Shanghai. The key epidemiological distributions were estimated and outcomes were also compared between patients whose illness were before 24 January and those whose illness were after 24 January. RESULTS: Of 161 discharged COVID-19 cases, the median age was 45 years, and 80 (49.7%) cases were male. All of the cases were categorized as clinical moderate type. The most common initial symptoms were fever (85.7%), cough (41.0%), fatigue (19.3%), muscle ache (17.4%), sputum production (14.9%), and there were six asymptomatic cases. 39 (24.2%) cases got infected in Shanghai, and three of them were second-generation cases of Shanghai native cases. The estimated median of the time from onset to first medical visit, admission, disease confirmation, and discharge for 161 cases was 1.0 day (95% CI, 0.6-1.2), 2.0 days (95% CI, 1.5-2.6), 5.2 days (95% CI, 4.6-5.7), 18.1 days (95% CI, 17.4-18.8), respectively. The estimated median of the time from admission to discharge was 14.0 days (95% CI, 13.3-14.6). The time from onset to first medical visit, admission and disease confirmation were all shortened after the Shanghai's first-level public health emergency response. In Cox regression model, the significant independent covariates for the duration of hospitalization were age, the time from onset to admission and the first-level public health emergency response. CONCLUSIONS: Local transmission had occurred in Shanghai in late January 2020. The estimated median of the time from onset to discharge of moderate COVID-19 was 18.1 days in Shanghai. Time intervals from onset to first medical visit, admission and disease confirmation were all shortened after the Shanghai's first-level public health emergency response. Age, the first-level public health emergency response and the time from onset to admission were the impact factors for the duration of hospitalization. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/33081711/Epidemiological_and_clinical_characteristics_of_161_discharged_cases_with_coronavirus_disease_2019_in_Shanghai_China_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05493-7 DB - PRIME DP - Unbound Medicine ER -