TY - JOUR T1 - Mitochondrial microRNA (MitomiRs) in cancer and complex mitochondrial diseases: current status and future perspectives. AU - Purohit,Paresh Kumar, AU - Saini,Neeru, Y1 - 2020/10/21/ PY - 2020/05/02/received PY - 2020/10/05/accepted PY - 2020/09/13/revised PY - 2020/10/22/pubmed PY - 2021/3/4/medline PY - 2020/10/21/entrez KW - Cancer KW - Cardiovascular disease KW - Clinical medicine KW - Diabetes KW - Metabolic disorders KW - Neurodegenerative disorders KW - microRNA KW - mitomiR SP - 1405 EP - 1421 JF - Cellular and molecular life sciences : CMLS JO - Cell Mol Life Sci VL - 78 IS - 4 N2 - Mitochondria are not only important for cellular bioenergetics but also lie at the heart of critical metabolic pathways. They can rapidly adjust themselves in response to changing conditions and the metabolic needs of the cell. Mitochondrial involvement as well as its dysfunction has been found to be associated with variety of pathological processes and diseases. mitomiRs are class of miRNA(s) that regulate mitochondrial gene expression and function. This review sheds light on the role of mitomiRs in regulating different biological processes-mitochondrial dynamics, oxidative stress, cell metabolism, chemoresistance, apoptosis,and their relevance in metabolic diseases, neurodegenerative disorders, and cancer. Insilico analysis of predicted targets of mitomiRs targeting energy metabolism identified several significantly altered pathways (needs in vivo validations) that may provide a new therapeutic approach for the treatment of human diseases. Last part of the review discusses about the clinical aspects of miRNA(s) and mitomiRs in Medicine. SN - 1420-9071 UR - https://www.unboundmedicine.com/medline/citation/33084945/Mitochondrial_microRNA__MitomiRs__in_cancer_and_complex_mitochondrial_diseases:_current_status_and_future_perspectives_ DB - PRIME DP - Unbound Medicine ER -