Tags

Type your tag names separated by a space and hit enter

An ultrastructural study of dermal nerves in early human leprosy.
Int J Lepr Other Mycobact Dis. 1987 Sep; 55(3):515-20.IJ

Abstract

Skin biopsies from the cutaneous lesions of seven patients with indeterminate, BT, BL, and LL leprosy of less than 1 year's duration were examined by light and electron microscopy. Inflammatory cells, which marked the location of Mycobacterium leprae in bacilliferous cases (BL and LL) were most frequently and consistently found in relation to dermal blood vessels, neurovascular bundles, nerves, arrector pili muscles, and skin adnexa. The number of bacilli and inflammatory cells in the epineurium was in great excess of those in the perineurium and endoneurium. Perineurial infiltration by lymphocytes and bacillated macrophages was seen to occur through gaps between the constituent cells of a loosened and sometimes proliferated perineurium. Bacillation of Schwann cells and associated inflammation in the endoneurium was minimal. M. leprae were identified in endothelial cells, arrector pili muscles, macrophages and Schwann cells. At this stage, inflammatory destruction of nerve fibers was not encountered. It is concluded that M. leprae which are extruded from the circulation into the epineurium (or perineurium) may be carried in inflammatory cells across the perineurium which is loosened and rendered permeable to inflammatory cells as a consequence of chronic inflammation in the adjacent epineurium. This is suggested as a very probable route for M. leprae to enter nerves.

Authors+Show Affiliations

Christian Medical College Hospital, Vellore, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3309090

Citation

Chandi, S M., and C J. Chacko. "An Ultrastructural Study of Dermal Nerves in Early Human Leprosy." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 55, no. 3, 1987, pp. 515-20.
Chandi SM, Chacko CJ. An ultrastructural study of dermal nerves in early human leprosy. Int J Lepr Other Mycobact Dis. 1987;55(3):515-20.
Chandi, S. M., & Chacko, C. J. (1987). An ultrastructural study of dermal nerves in early human leprosy. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 55(3), 515-20.
Chandi SM, Chacko CJ. An Ultrastructural Study of Dermal Nerves in Early Human Leprosy. Int J Lepr Other Mycobact Dis. 1987;55(3):515-20. PubMed PMID: 3309090.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An ultrastructural study of dermal nerves in early human leprosy. AU - Chandi,S M, AU - Chacko,C J, PY - 1987/9/1/pubmed PY - 1987/9/1/medline PY - 1987/9/1/entrez SP - 515 EP - 20 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 55 IS - 3 N2 - Skin biopsies from the cutaneous lesions of seven patients with indeterminate, BT, BL, and LL leprosy of less than 1 year's duration were examined by light and electron microscopy. Inflammatory cells, which marked the location of Mycobacterium leprae in bacilliferous cases (BL and LL) were most frequently and consistently found in relation to dermal blood vessels, neurovascular bundles, nerves, arrector pili muscles, and skin adnexa. The number of bacilli and inflammatory cells in the epineurium was in great excess of those in the perineurium and endoneurium. Perineurial infiltration by lymphocytes and bacillated macrophages was seen to occur through gaps between the constituent cells of a loosened and sometimes proliferated perineurium. Bacillation of Schwann cells and associated inflammation in the endoneurium was minimal. M. leprae were identified in endothelial cells, arrector pili muscles, macrophages and Schwann cells. At this stage, inflammatory destruction of nerve fibers was not encountered. It is concluded that M. leprae which are extruded from the circulation into the epineurium (or perineurium) may be carried in inflammatory cells across the perineurium which is loosened and rendered permeable to inflammatory cells as a consequence of chronic inflammation in the adjacent epineurium. This is suggested as a very probable route for M. leprae to enter nerves. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/3309090/An_ultrastructural_study_of_dermal_nerves_in_early_human_leprosy_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.