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Longitudinal Changes in the Retinal Microstructures of Eyes With Chiasmal Compression.
Neurology. 2021 01 05; 96(1):e131-e140.Neur

Abstract

OBJECTIVE

To test the hypothesis that there was a temporal change in the retinal microstructure after decompression surgery for chiasmal compression, the 1-year longitudinal changes in the inner and outer retinal thickness after decompression surgery were analyzed using spectral-domain optical coherence tomography (SD-OCT) with linear mixed-effects models.

METHODS

SD-OCT was obtained from 87 eyes with chiasmal compression and compared to 100 healthy controls. The preoperative and 1-year postoperative longitudinal changes in the retinal layer thickness were measured. The thickness of each of the following retinal layers was analyzed: the macular retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), the inner plexiform layer (IPL), the inner nuclear layer, the outer plexiform layer, the outer nuclear layer, and the photoreceptor layer.

RESULTS

The RNFL, GCL, and IPL showed thinning at a rate of 1.068 μm/y (95% confidence interval [CI], 0.523, 1.613), 1.189 μm/y (95% CI 0.452, 1.925), and 1.177 μm/y (95% CI 0.645, 1.709), respectively, after decompression surgery. The preoperative thickness of the intraretinal layer was associated with postoperative visual field recovery (RNFL, odds ratio [OR] 1.221, 95% CI 1.058, 1.410; GCL, OR 1.133, 95% CI 1.024, 1.254; and IPL, OR 1.174, 95% CI 1.002, 1.376).

CONCLUSIONS

The changes in retinal microstructure persisted and progressed in eyes with chiasmal compression after decompression surgery. The findings provide insight into the biological and anatomical sequelae following chiasmal compression. The preoperative thickness of the inner retinal layers was associated with postoperative visual field recovery.

Authors+Show Affiliations

From the Department of Ophthalmology (G.-I.L., K.Y.S., K.-A.P., S.Y.O.) and Department of Neurosurgery, Endoscopic Skull Base Surgery Clinic, Brain Tumor Center (D.-S.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.From the Department of Ophthalmology (G.-I.L., K.Y.S., K.-A.P., S.Y.O.) and Department of Neurosurgery, Endoscopic Skull Base Surgery Clinic, Brain Tumor Center (D.-S.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.From the Department of Ophthalmology (G.-I.L., K.Y.S., K.-A.P., S.Y.O.) and Department of Neurosurgery, Endoscopic Skull Base Surgery Clinic, Brain Tumor Center (D.-S.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. syoh@skku.edu kparkoph@skku.edu.From the Department of Ophthalmology (G.-I.L., K.Y.S., K.-A.P., S.Y.O.) and Department of Neurosurgery, Endoscopic Skull Base Surgery Clinic, Brain Tumor Center (D.-S.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.From the Department of Ophthalmology (G.-I.L., K.Y.S., K.-A.P., S.Y.O.) and Department of Neurosurgery, Endoscopic Skull Base Surgery Clinic, Brain Tumor Center (D.-S.K.), Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. syoh@skku.edu kparkoph@skku.edu.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33093228

Citation

Lee, Ga-In, et al. "Longitudinal Changes in the Retinal Microstructures of Eyes With Chiasmal Compression." Neurology, vol. 96, no. 1, 2021, pp. e131-e140.
Lee GI, Son KY, Park KA, et al. Longitudinal Changes in the Retinal Microstructures of Eyes With Chiasmal Compression. Neurology. 2021;96(1):e131-e140.
Lee, G. I., Son, K. Y., Park, K. A., Kong, D. S., & Oh, S. Y. (2021). Longitudinal Changes in the Retinal Microstructures of Eyes With Chiasmal Compression. Neurology, 96(1), e131-e140. https://doi.org/10.1212/WNL.0000000000011087
Lee GI, et al. Longitudinal Changes in the Retinal Microstructures of Eyes With Chiasmal Compression. Neurology. 2021 01 5;96(1):e131-e140. PubMed PMID: 33093228.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal Changes in the Retinal Microstructures of Eyes With Chiasmal Compression. AU - Lee,Ga-In, AU - Son,Ki Young, AU - Park,Kyung-Ah, AU - Kong,Doo-Sik, AU - Oh,Sei Yeul, Y1 - 2020/10/22/ PY - 2020/02/25/received PY - 2020/08/20/accepted PY - 2020/10/24/pubmed PY - 2021/1/16/medline PY - 2020/10/23/entrez SP - e131 EP - e140 JF - Neurology JO - Neurology VL - 96 IS - 1 N2 - OBJECTIVE: To test the hypothesis that there was a temporal change in the retinal microstructure after decompression surgery for chiasmal compression, the 1-year longitudinal changes in the inner and outer retinal thickness after decompression surgery were analyzed using spectral-domain optical coherence tomography (SD-OCT) with linear mixed-effects models. METHODS: SD-OCT was obtained from 87 eyes with chiasmal compression and compared to 100 healthy controls. The preoperative and 1-year postoperative longitudinal changes in the retinal layer thickness were measured. The thickness of each of the following retinal layers was analyzed: the macular retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), the inner plexiform layer (IPL), the inner nuclear layer, the outer plexiform layer, the outer nuclear layer, and the photoreceptor layer. RESULTS: The RNFL, GCL, and IPL showed thinning at a rate of 1.068 μm/y (95% confidence interval [CI], 0.523, 1.613), 1.189 μm/y (95% CI 0.452, 1.925), and 1.177 μm/y (95% CI 0.645, 1.709), respectively, after decompression surgery. The preoperative thickness of the intraretinal layer was associated with postoperative visual field recovery (RNFL, odds ratio [OR] 1.221, 95% CI 1.058, 1.410; GCL, OR 1.133, 95% CI 1.024, 1.254; and IPL, OR 1.174, 95% CI 1.002, 1.376). CONCLUSIONS: The changes in retinal microstructure persisted and progressed in eyes with chiasmal compression after decompression surgery. The findings provide insight into the biological and anatomical sequelae following chiasmal compression. The preoperative thickness of the inner retinal layers was associated with postoperative visual field recovery. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/33093228/Longitudinal_Changes_in_the_Retinal_Microstructures_of_Eyes_With_Chiasmal_Compression_ DB - PRIME DP - Unbound Medicine ER -