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Metabolic control and B cell function in patients with insulin-dependent diabetes mellitus secondary to chronic pancreatitis.
Metabolism. 1987 Oct; 36(10):964-7.M

Abstract

Among 88 unselected patients with chronic pancreatitis 35% (95% confidence limits 25 to 46) had insulin-dependent diabetes, 31% (21% to 41%) had non-insulin-dependent diabetes or impaired glucose tolerance (by intravenous glucose tolerance test), and 34% (24% to 45%) had normal glucose tolerance. B cell function measured by C-peptide concentration after 1 mg glucagon IV correlated with the pancreatic enzyme secretion (meal stimulated duodenal lipase content). B cell function was preserved to a greater extent (P less than .01), and glycosylated hemoglobin and fasting level of glucose were lower (P less than .01 to .05) in the 31 patients with pancreatogenic diabetes than than in 35 otherwise comparable patients with type I (insulin-dependent) diabetes, yet daily insulin dose was similar in the two groups. Glucagon stimulated C-peptide was inversely correlated to glycosylated hemoglobin in insulin-dependent patients with pancreatogenic diabetes and in type I diabetes. Since body mass indices were identical in the two groups, better glucoregulation was not due to reduced food intake or malabsorption in pancreatogenic diabetes. Rather residual B cell function and/or different secretion of other pancreatic hormones in pancreatogenic diabetes may account for different metabolic control in type I IDDM compared with insulin-dependent pancreatogenic diabetes.

Authors+Show Affiliations

Larsen S
Medical Department F, Glostrup Hospital, Denmark.
Hilsted J
No affiliation info available
Tronier B
No affiliation info available
Worning H
No affiliation info available

MeSH

AdultC-PeptideChronic DiseaseDiabetes MellitusDiabetes Mellitus, Type 1FemaleGlucagonHumansIslets of LangerhansMaleMiddle AgedPancreatitis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3309547

Citation

Larsen, S, et al. "Metabolic Control and B Cell Function in Patients With Insulin-dependent Diabetes Mellitus Secondary to Chronic Pancreatitis." Metabolism: Clinical and Experimental, vol. 36, no. 10, 1987, pp. 964-7.
Larsen S, Hilsted J, Tronier B, et al. Metabolic control and B cell function in patients with insulin-dependent diabetes mellitus secondary to chronic pancreatitis. Metabolism. 1987;36(10):964-7.
Larsen, S., Hilsted, J., Tronier, B., & Worning, H. (1987). Metabolic control and B cell function in patients with insulin-dependent diabetes mellitus secondary to chronic pancreatitis. Metabolism: Clinical and Experimental, 36(10), 964-7.
Larsen S, et al. Metabolic Control and B Cell Function in Patients With Insulin-dependent Diabetes Mellitus Secondary to Chronic Pancreatitis. Metabolism. 1987;36(10):964-7. PubMed PMID: 3309547.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic control and B cell function in patients with insulin-dependent diabetes mellitus secondary to chronic pancreatitis. AU - Larsen,S, AU - Hilsted,J, AU - Tronier,B, AU - Worning,H, PY - 1987/10/1/pubmed PY - 1987/10/1/medline PY - 1987/10/1/entrez SP - 964 EP - 7 JF - Metabolism: clinical and experimental JO - Metabolism VL - 36 IS - 10 N2 - Among 88 unselected patients with chronic pancreatitis 35% (95% confidence limits 25 to 46) had insulin-dependent diabetes, 31% (21% to 41%) had non-insulin-dependent diabetes or impaired glucose tolerance (by intravenous glucose tolerance test), and 34% (24% to 45%) had normal glucose tolerance. B cell function measured by C-peptide concentration after 1 mg glucagon IV correlated with the pancreatic enzyme secretion (meal stimulated duodenal lipase content). B cell function was preserved to a greater extent (P less than .01), and glycosylated hemoglobin and fasting level of glucose were lower (P less than .01 to .05) in the 31 patients with pancreatogenic diabetes than than in 35 otherwise comparable patients with type I (insulin-dependent) diabetes, yet daily insulin dose was similar in the two groups. Glucagon stimulated C-peptide was inversely correlated to glycosylated hemoglobin in insulin-dependent patients with pancreatogenic diabetes and in type I diabetes. Since body mass indices were identical in the two groups, better glucoregulation was not due to reduced food intake or malabsorption in pancreatogenic diabetes. Rather residual B cell function and/or different secretion of other pancreatic hormones in pancreatogenic diabetes may account for different metabolic control in type I IDDM compared with insulin-dependent pancreatogenic diabetes. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/3309547/Metabolic_control_and_B_cell_function_in_patients_with_insulin_dependent_diabetes_mellitus_secondary_to_chronic_pancreatitis_ DB - PRIME DP - Unbound Medicine ER -