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Cardiac injury prediction and lymphocyte immunity and inflammation analysis in hospitalized patients with coronavirus disease 2019 (COVID-19).
Int J Cardiol. 2021 03 01; 326:237-242.IJ

Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic. The ability to predict cardiac injury and analyze lymphocyte immunity and inflammation of cardiac damage in patients with COVID-19 is limited. We aimed to determine the risk factors and predictive markers of cardiac injury in these patients.

METHODS

Data from 124 consecutive hospitalized patients with confirmed COVID-19 were collected. We compared the proportion of cardiovascular disease history in moderate, severe, and critical cases. We obtained high-sensitivity cardiac troponin I (hs-cTn I) results from 68 patients. Patients were divided into two groups based on positive hs-cTn I result: those with cardiac injury (n = 19) and those without cardiac injury (n = 49).

RESULTS

Compared with the group with moderate disease, hypertension, coronary heart disease, and smoking were more common in severe and critical cases. Diabetes mellitus was most common in the critical group. Age older than 65 years, presence of chronic kidney disease, and lower blood lymphocyte percentage were independent risk factors of cardiac injury. The total T- and B-lymphocyte counts and CD4+ and CD8+ T-cell counts were significantly lower in those with cardiac injury. A minimal lymphocyte percentage < 7.8% may predict cardiac injury. The interleukin (IL) 6 level in plasma was elevated in the group with cardiac injury.

CONCLUSIONS

The lymphocyte percentage in blood may become a predictive marker of cardiac injury in COVID-19 patients. The total T and B cells and CD4+ and CD8+ cell counts decreased and the IL-6 level increased in COVID-19 patients with cardiac injury.

Authors+Show Affiliations

The Center of Cardiovascular Diseases, the First Hospital of Jilin University, Changchun 130021, China.The Center of Cardiovascular Diseases, the First Hospital of Jilin University, Changchun 130021, China.The Center of Cardiovascular Diseases, the First Hospital of Jilin University, Changchun 130021, China.The Center of Cardiovascular Diseases, the First Hospital of Jilin University, Changchun 130021, China.The Center of Cardiovascular Diseases, the First Hospital of Jilin University, Changchun 130021, China.The Center of Cardiovascular Diseases, the First Hospital of Jilin University, Changchun 130021, China.Department of Respiratory Medicine, the First Hospital of Jilin University-the Eastern Division, Changhun 130031, China.The Center of Cardiovascular Diseases, the First Hospital of Jilin University, Changchun 130021, China. Electronic address: zhengyang@jlu.edu.cn.The Center of Cardiovascular Diseases, the First Hospital of Jilin University, Changchun 130021, China. Electronic address: yushi@jlu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33098952

Citation

Zhou, Wenqian, et al. "Cardiac Injury Prediction and Lymphocyte Immunity and Inflammation Analysis in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19)." International Journal of Cardiology, vol. 326, 2021, pp. 237-242.
Zhou W, Song L, Wang X, et al. Cardiac injury prediction and lymphocyte immunity and inflammation analysis in hospitalized patients with coronavirus disease 2019 (COVID-19). Int J Cardiol. 2021;326:237-242.
Zhou, W., Song, L., Wang, X., Xu, Z., Wang, S., Wang, J., Xu, H., Zheng, Y., & Wang, Y. (2021). Cardiac injury prediction and lymphocyte immunity and inflammation analysis in hospitalized patients with coronavirus disease 2019 (COVID-19). International Journal of Cardiology, 326, 237-242. https://doi.org/10.1016/j.ijcard.2020.10.049
Zhou W, et al. Cardiac Injury Prediction and Lymphocyte Immunity and Inflammation Analysis in Hospitalized Patients With Coronavirus Disease 2019 (COVID-19). Int J Cardiol. 2021 03 1;326:237-242. PubMed PMID: 33098952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiac injury prediction and lymphocyte immunity and inflammation analysis in hospitalized patients with coronavirus disease 2019 (COVID-19). AU - Zhou,Wenqian, AU - Song,Ling, AU - Wang,Xiang, AU - Xu,Zheng, AU - Wang,Shudong, AU - Wang,Jiqun, AU - Xu,He, AU - Zheng,Yang, AU - Wang,Yushi, Y1 - 2020/10/22/ PY - 2020/04/19/received PY - 2020/10/11/revised PY - 2020/10/15/accepted PY - 2020/10/26/pubmed PY - 2021/2/24/medline PY - 2020/10/25/entrez KW - Cardiac injury KW - Coronavirus disease 2019 KW - Inflammation KW - Lymphocyte immunity SP - 237 EP - 242 JF - International journal of cardiology JO - Int J Cardiol VL - 326 N2 - BACKGROUND: Coronavirus disease 2019 (COVID-19) is an ongoing global pandemic. The ability to predict cardiac injury and analyze lymphocyte immunity and inflammation of cardiac damage in patients with COVID-19 is limited. We aimed to determine the risk factors and predictive markers of cardiac injury in these patients. METHODS: Data from 124 consecutive hospitalized patients with confirmed COVID-19 were collected. We compared the proportion of cardiovascular disease history in moderate, severe, and critical cases. We obtained high-sensitivity cardiac troponin I (hs-cTn I) results from 68 patients. Patients were divided into two groups based on positive hs-cTn I result: those with cardiac injury (n = 19) and those without cardiac injury (n = 49). RESULTS: Compared with the group with moderate disease, hypertension, coronary heart disease, and smoking were more common in severe and critical cases. Diabetes mellitus was most common in the critical group. Age older than 65 years, presence of chronic kidney disease, and lower blood lymphocyte percentage were independent risk factors of cardiac injury. The total T- and B-lymphocyte counts and CD4+ and CD8+ T-cell counts were significantly lower in those with cardiac injury. A minimal lymphocyte percentage < 7.8% may predict cardiac injury. The interleukin (IL) 6 level in plasma was elevated in the group with cardiac injury. CONCLUSIONS: The lymphocyte percentage in blood may become a predictive marker of cardiac injury in COVID-19 patients. The total T and B cells and CD4+ and CD8+ cell counts decreased and the IL-6 level increased in COVID-19 patients with cardiac injury. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/33098952/Cardiac_injury_prediction_and_lymphocyte_immunity_and_inflammation_analysis_in_hospitalized_patients_with_coronavirus_disease_2019__COVID_19__ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(20)34002-X DB - PRIME DP - Unbound Medicine ER -