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Stretchable Electrochemical Biosensing Platform Based on Ni-MOF Composite/Au Nanoparticle-Coated Carbon Nanotubes for Real-Time Monitoring of Dopamine Released from Living Cells.
ACS Appl Mater Interfaces. 2020 Nov 04; 12(44):49480-49488.AA

Abstract

Existing electrochemical biosensing platforms, using traditional rigid and unstretchable electrodes, cannot monitor the biological signaling molecules released by cells in a mechanically deformed state in real time. Here, a stretchable and flexible electrochemical sensor was developed based on nickel metal-organic framework composite/Au nanoparticle-coated carbon nanotubes (Ni-MOF composite/AuNPs/CNTs) for sensitive detection of dopamine (DA) released by C6 living cells in real time. A Ni-MOF composite was obtained by introducing Ni, NiO, and a carbon frame onto the surface of two-dimensional (2D) Ni-MOF nanosheets using an efficient one-step calcination method. The hybrid of Ni-MOF composite/AuNPs/CNTs that deposited on the poly(dimethylsiloxane) (PDMS) film endowed the sensor with excellent electrochemical performance with a wide linear range of 50 nM to 15 μM and a high sensitivity of 1250 mA/(cm2 M) and also provided the sensor with desirable stability against mechanical deformation. Furthermore, the stretchable electrode also displayed good cellular compatibility while C6 living cells can be cultured and proliferated on it with strong adhesion. Then, the DA released by C6 living cells with chemical induction in both natural and stretched states was monitored using our stretchable and flexible electrochemical sensor in real time. This indicates that our new design of flexible Ni-MOF composite/AuNPs/CNTs/PDMS (NACP) film electrodes provides more opportunities for the detection of chemical signals released from cells and soft living organisms even under mechanically deformed states.

Authors+Show Affiliations

School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China.School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China.School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China.School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China.Department of Chemical Engineering, Yangzhou Polytechnic Institute, Yangzhou 225127, P. R. China.School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China.School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China.School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33100007

Citation

Shu, Yun, et al. "Stretchable Electrochemical Biosensing Platform Based On Ni-MOF Composite/Au Nanoparticle-Coated Carbon Nanotubes for Real-Time Monitoring of Dopamine Released From Living Cells." ACS Applied Materials & Interfaces, vol. 12, no. 44, 2020, pp. 49480-49488.
Shu Y, Lu Q, Yuan F, et al. Stretchable Electrochemical Biosensing Platform Based on Ni-MOF Composite/Au Nanoparticle-Coated Carbon Nanotubes for Real-Time Monitoring of Dopamine Released from Living Cells. ACS Appl Mater Interfaces. 2020;12(44):49480-49488.
Shu, Y., Lu, Q., Yuan, F., Tao, Q., Jin, D., Yao, H., Xu, Q., & Hu, X. (2020). Stretchable Electrochemical Biosensing Platform Based on Ni-MOF Composite/Au Nanoparticle-Coated Carbon Nanotubes for Real-Time Monitoring of Dopamine Released from Living Cells. ACS Applied Materials & Interfaces, 12(44), 49480-49488. https://doi.org/10.1021/acsami.0c16060
Shu Y, et al. Stretchable Electrochemical Biosensing Platform Based On Ni-MOF Composite/Au Nanoparticle-Coated Carbon Nanotubes for Real-Time Monitoring of Dopamine Released From Living Cells. ACS Appl Mater Interfaces. 2020 Nov 4;12(44):49480-49488. PubMed PMID: 33100007.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stretchable Electrochemical Biosensing Platform Based on Ni-MOF Composite/Au Nanoparticle-Coated Carbon Nanotubes for Real-Time Monitoring of Dopamine Released from Living Cells. AU - Shu,Yun, AU - Lu,Qin, AU - Yuan,Fan, AU - Tao,Qi, AU - Jin,Dangqin, AU - Yao,Hang, AU - Xu,Qin, AU - Hu,Xiaoya, Y1 - 2020/10/25/ PY - 2020/10/27/pubmed PY - 2021/2/27/medline PY - 2020/10/26/entrez KW - carbon nanotubes KW - dopamine KW - electrocatalytic activity KW - flexible electrochemical sensor KW - living cells KW - nickel metal−organic framework composite KW - stretchable film electrode SP - 49480 EP - 49488 JF - ACS applied materials & interfaces JO - ACS Appl Mater Interfaces VL - 12 IS - 44 N2 - Existing electrochemical biosensing platforms, using traditional rigid and unstretchable electrodes, cannot monitor the biological signaling molecules released by cells in a mechanically deformed state in real time. Here, a stretchable and flexible electrochemical sensor was developed based on nickel metal-organic framework composite/Au nanoparticle-coated carbon nanotubes (Ni-MOF composite/AuNPs/CNTs) for sensitive detection of dopamine (DA) released by C6 living cells in real time. A Ni-MOF composite was obtained by introducing Ni, NiO, and a carbon frame onto the surface of two-dimensional (2D) Ni-MOF nanosheets using an efficient one-step calcination method. The hybrid of Ni-MOF composite/AuNPs/CNTs that deposited on the poly(dimethylsiloxane) (PDMS) film endowed the sensor with excellent electrochemical performance with a wide linear range of 50 nM to 15 μM and a high sensitivity of 1250 mA/(cm2 M) and also provided the sensor with desirable stability against mechanical deformation. Furthermore, the stretchable electrode also displayed good cellular compatibility while C6 living cells can be cultured and proliferated on it with strong adhesion. Then, the DA released by C6 living cells with chemical induction in both natural and stretched states was monitored using our stretchable and flexible electrochemical sensor in real time. This indicates that our new design of flexible Ni-MOF composite/AuNPs/CNTs/PDMS (NACP) film electrodes provides more opportunities for the detection of chemical signals released from cells and soft living organisms even under mechanically deformed states. SN - 1944-8252 UR - https://www.unboundmedicine.com/medline/citation/33100007/Stretchable_Electrochemical_Biosensing_Platform_Based_on_Ni_MOF_Composite/Au_Nanoparticle_Coated_Carbon_Nanotubes_for_Real_Time_Monitoring_of_Dopamine_Released_from_Living_Cells_ L2 - https://doi.org/10.1021/acsami.0c16060 DB - PRIME DP - Unbound Medicine ER -