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Erythroleukemia treated effects of rat plasma profile and erythrocyte membranes.
Saudi J Biol Sci. 2020 Nov; 27(11):2948-2954.SJ

Abstract

Erythroleukemia disease is caused by over production of malignant blood and immature large number of blood cells enters into peripheral compartment. Biophysical and biochemical changes in plasma and erythrocyte membrane in erythroleukemia treated rats were identified. Our study, leukemia is experimentally exposed in rats were injecting erythroleukemia cells (FLC) (H-2d) intravenously in adult rats and normal control rats were maintained. Significant increase in the activity of blood glucose, proteins levels, aspartate transaminase (AST) and alanine transaminase (ALT) values and significant decrease in haemoglobin (Hb), albumin levels in erythroleukemia treated rats were observed when compared with control rats. Cholesterol and low density liproprotein (LDL) levels increased significantly in erythroleukemia treated rats but triglycerides, high density lipoprotein (HDL) and very low density lipoprotein (VLDL) levels decreased significantly. Levels of red cell membrane cholesterol decreased in erythroleukemia treated rats in comparison with control while levels of phospholipids and proteins increased in erythrocytes of erythroleukemia treated rats. Red blood cell (RBC) and white blood cell (WBC) counts increased significantly and platelet count decreased. C/P (cholesterol/phospholipid) ratio decreased significantly in erythroleukemia treated rats. This study has been undertaken for the first time to investigate the effect of (FLC) (H-2d) erythroleukemia cells (treated) in intravenously in adult rats and normal control rats. Results indicate biophysical and biochemical alterations at molecular level in plasma and erythrocyte membrane.

Authors+Show Affiliations

Department of Hematology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650032, China.Department of Biochemistry, Sri Krishnadevaraya University, Ananthapuramu 515003, Andhra Pradesh, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33100851

Citation

Yu, Liqun, and Narendra Maddu. "Erythroleukemia Treated Effects of Rat Plasma Profile and Erythrocyte Membranes." Saudi Journal of Biological Sciences, vol. 27, no. 11, 2020, pp. 2948-2954.
Yu L, Maddu N. Erythroleukemia treated effects of rat plasma profile and erythrocyte membranes. Saudi J Biol Sci. 2020;27(11):2948-2954.
Yu, L., & Maddu, N. (2020). Erythroleukemia treated effects of rat plasma profile and erythrocyte membranes. Saudi Journal of Biological Sciences, 27(11), 2948-2954. https://doi.org/10.1016/j.sjbs.2020.07.032
Yu L, Maddu N. Erythroleukemia Treated Effects of Rat Plasma Profile and Erythrocyte Membranes. Saudi J Biol Sci. 2020;27(11):2948-2954. PubMed PMID: 33100851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythroleukemia treated effects of rat plasma profile and erythrocyte membranes. AU - Yu,Liqun, AU - Maddu,Narendra, Y1 - 2020/08/03/ PY - 2020/05/15/received PY - 2020/07/17/revised PY - 2020/07/27/accepted PY - 2020/10/26/entrez PY - 2020/10/27/pubmed PY - 2020/10/27/medline KW - ALT KW - AST KW - Erythrocyte membrane KW - Erythroleukemia KW - Plasma cholesterol SP - 2948 EP - 2954 JF - Saudi journal of biological sciences JO - Saudi J Biol Sci VL - 27 IS - 11 N2 - Erythroleukemia disease is caused by over production of malignant blood and immature large number of blood cells enters into peripheral compartment. Biophysical and biochemical changes in plasma and erythrocyte membrane in erythroleukemia treated rats were identified. Our study, leukemia is experimentally exposed in rats were injecting erythroleukemia cells (FLC) (H-2d) intravenously in adult rats and normal control rats were maintained. Significant increase in the activity of blood glucose, proteins levels, aspartate transaminase (AST) and alanine transaminase (ALT) values and significant decrease in haemoglobin (Hb), albumin levels in erythroleukemia treated rats were observed when compared with control rats. Cholesterol and low density liproprotein (LDL) levels increased significantly in erythroleukemia treated rats but triglycerides, high density lipoprotein (HDL) and very low density lipoprotein (VLDL) levels decreased significantly. Levels of red cell membrane cholesterol decreased in erythroleukemia treated rats in comparison with control while levels of phospholipids and proteins increased in erythrocytes of erythroleukemia treated rats. Red blood cell (RBC) and white blood cell (WBC) counts increased significantly and platelet count decreased. C/P (cholesterol/phospholipid) ratio decreased significantly in erythroleukemia treated rats. This study has been undertaken for the first time to investigate the effect of (FLC) (H-2d) erythroleukemia cells (treated) in intravenously in adult rats and normal control rats. Results indicate biophysical and biochemical alterations at molecular level in plasma and erythrocyte membrane. SN - 1319-562X UR - https://www.unboundmedicine.com/medline/citation/33100851/Erythroleukemia_treated_effects_of_rat_plasma_profile_and_erythrocyte_membranes L2 - https://linkinghub.elsevier.com/retrieve/pii/S1319-562X(20)30332-6 DB - PRIME DP - Unbound Medicine ER -
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