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TFII-I/Gtf2i and Erythro-Megakaryopoiesis.
Front Physiol. 2020; 11:590180.FP

Abstract

TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer. Williams-Beuren Syndrome (WBS) is caused by a large hemizygous deletion on chromosome 7q11.23 which encompasses 26-28 genes, including GTF2I, the human gene encoding TFII-I. A subset of WBS patients has recently been shown to present with macrocytosis, a mild anemia characterized by enlarged erythrocytes. We conditionally deleted the TFII-I/Gtf2i gene in adult mice by tamoxifen induced Cre-recombination. Bone marrow cells revealed defects in erythro-megakaryopoiesis and an increase in expression of the adult β-globin gene. The data show that TFII-I acts as a repressor of β-globin gene transcription and that it is implicated in the differentiation of erythro-megakaryocytic cells.

Authors+Show Affiliations

Department of Biochemistry and Molecular Biology, College of Medicine, UF Health Cancer Center, Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States.Division of Medicine and Department of Biochemistry and Molecular Biology, UF Health Cancer Center, University of Florida, Gainesville, FL, United States.Department of Biochemistry and Molecular Biology, College of Medicine, UF Health Cancer Center, Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States.Department of Biochemistry and Molecular Biology, College of Medicine, UF Health Cancer Center, Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States.Department of Biochemistry and Molecular Biology, College of Medicine, UF Health Cancer Center, Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States.Department of Biochemistry and Molecular Biology, College of Medicine, UF Health Cancer Center, Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States.Sprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.Comprehensive Cancer Center, School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.Division of Medicine and Department of Biochemistry and Molecular Biology, UF Health Cancer Center, University of Florida, Gainesville, FL, United States.Department of Biochemistry and Molecular Biology, College of Medicine, UF Health Cancer Center, Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33101065

Citation

Gurumurthy, Aishwarya, et al. "TFII-I/Gtf2i and Erythro-Megakaryopoiesis." Frontiers in Physiology, vol. 11, 2020, p. 590180.
Gurumurthy A, Wu Q, Nar R, et al. TFII-I/Gtf2i and Erythro-Megakaryopoiesis. Front Physiol. 2020;11:590180.
Gurumurthy, A., Wu, Q., Nar, R., Paulsen, K., Trumbull, A., Fishman, R. C., Brand, M., Strouboulis, J., Qian, Z., & Bungert, J. (2020). TFII-I/Gtf2i and Erythro-Megakaryopoiesis. Frontiers in Physiology, 11, 590180. https://doi.org/10.3389/fphys.2020.590180
Gurumurthy A, et al. TFII-I/Gtf2i and Erythro-Megakaryopoiesis. Front Physiol. 2020;11:590180. PubMed PMID: 33101065.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - TFII-I/Gtf2i and Erythro-Megakaryopoiesis. AU - Gurumurthy,Aishwarya, AU - Wu,Qiong, AU - Nar,Rukiye, AU - Paulsen,Kimberly, AU - Trumbull,Alexis, AU - Fishman,Ryan C, AU - Brand,Marjorie, AU - Strouboulis,John, AU - Qian,Zhijian, AU - Bungert,Jörg, Y1 - 2020/09/25/ PY - 2020/07/31/received PY - 2020/09/08/accepted PY - 2020/10/26/entrez PY - 2020/10/27/pubmed PY - 2020/10/27/medline KW - Gtf2i KW - TFII-I KW - erythropoiesis KW - globin KW - megakaryopoiesis KW - transcription factor SP - 590180 EP - 590180 JF - Frontiers in physiology JO - Front Physiol VL - 11 N2 - TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer. Williams-Beuren Syndrome (WBS) is caused by a large hemizygous deletion on chromosome 7q11.23 which encompasses 26-28 genes, including GTF2I, the human gene encoding TFII-I. A subset of WBS patients has recently been shown to present with macrocytosis, a mild anemia characterized by enlarged erythrocytes. We conditionally deleted the TFII-I/Gtf2i gene in adult mice by tamoxifen induced Cre-recombination. Bone marrow cells revealed defects in erythro-megakaryopoiesis and an increase in expression of the adult β-globin gene. The data show that TFII-I acts as a repressor of β-globin gene transcription and that it is implicated in the differentiation of erythro-megakaryocytic cells. SN - 1664-042X UR - https://www.unboundmedicine.com/medline/citation/33101065/TFII-I/Gtf2i_and_Erythro-Megakaryopoiesis L2 - https://doi.org/10.3389/fphys.2020.590180 DB - PRIME DP - Unbound Medicine ER -
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