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Covid-19: Perspectives on Innate Immune Evasion.
Front Immunol. 2020; 11:580641.FI

Abstract

The ongoing outbreak of Coronavirus disease 2019 infection achieved pandemic status on March 11, 2020. As of September 8, 2020 it has caused over 890,000 mortalities world-wide. Coronaviral infections are enabled by potent immunoevasory mechanisms that target multiple aspects of innate immunity, with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) able to induce a cytokine storm, impair interferon responses, and suppress antigen presentation on both MHC class I and class II. Understanding the immune responses to SARS-CoV-2 and its immunoevasion approaches will improve our understanding of pathogenesis, virus clearance, and contribute toward vaccine and immunotherepeutic design and evaluation. This review discusses the known host innate immune response and immune evasion mechanisms driving SARS-CoV-2 infection and pathophysiology.

Authors+Show Affiliations

Department of Microbiology and Immunology, Center for Human Immunology, The University of Western Ontario, London, ON, Canada.Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Microbiology and Immunology, Center for Human Immunology, The University of Western Ontario, London, ON, Canada. Robarts Research Institute, London, ON, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

33101306

Citation

Taefehshokr, Nima, et al. "Covid-19: Perspectives On Innate Immune Evasion." Frontiers in Immunology, vol. 11, 2020, p. 580641.
Taefehshokr N, Taefehshokr S, Hemmat N, et al. Covid-19: Perspectives on Innate Immune Evasion. Front Immunol. 2020;11:580641.
Taefehshokr, N., Taefehshokr, S., Hemmat, N., & Heit, B. (2020). Covid-19: Perspectives on Innate Immune Evasion. Frontiers in Immunology, 11, 580641. https://doi.org/10.3389/fimmu.2020.580641
Taefehshokr N, et al. Covid-19: Perspectives On Innate Immune Evasion. Front Immunol. 2020;11:580641. PubMed PMID: 33101306.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Covid-19: Perspectives on Innate Immune Evasion. AU - Taefehshokr,Nima, AU - Taefehshokr,Sina, AU - Hemmat,Nima, AU - Heit,Bryan, Y1 - 2020/09/30/ PY - 2020/07/06/received PY - 2020/09/11/accepted PY - 2020/10/26/entrez PY - 2020/10/27/pubmed PY - 2020/11/11/medline KW - MHC trafficking KW - SARS-CoV-2 KW - cytokine - immunological terms KW - innnate immune KW - macropahge SP - 580641 EP - 580641 JF - Frontiers in immunology JO - Front Immunol VL - 11 N2 - The ongoing outbreak of Coronavirus disease 2019 infection achieved pandemic status on March 11, 2020. As of September 8, 2020 it has caused over 890,000 mortalities world-wide. Coronaviral infections are enabled by potent immunoevasory mechanisms that target multiple aspects of innate immunity, with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) able to induce a cytokine storm, impair interferon responses, and suppress antigen presentation on both MHC class I and class II. Understanding the immune responses to SARS-CoV-2 and its immunoevasion approaches will improve our understanding of pathogenesis, virus clearance, and contribute toward vaccine and immunotherepeutic design and evaluation. This review discusses the known host innate immune response and immune evasion mechanisms driving SARS-CoV-2 infection and pathophysiology. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/33101306/Covid_19:_Perspectives_on_Innate_Immune_Evasion_ L2 - https://doi.org/10.3389/fimmu.2020.580641 DB - PRIME DP - Unbound Medicine ER -