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Dietary Total Antioxidant Capacity and Gestational Diabetes Mellitus: A Case-Control Study.
Oxid Med Cell Longev. 2020; 2020:5471316.OM

Abstract

BACKGROUND

Elevated oxidative stress status has been reported among pregnant women with gestational diabetes mellitus (GDM). In diabetic condition, glucose and lipid peroxidation, and alteration in antioxidant defense lead to increased free radicals. The objective of this study was to investigate the association between dietary total antioxidant capacity (DTAC) and GDM.

METHODS

This hospital-based case-control study was conducted in 463 pregnant women (healthy, n = 263; GDM, n = 200). Anthropometric indices, blood pressure, and biochemical analyses were measured. Dietary intake was assessed by the average of three 24-hour dietary intake records. DTAC was calculated by three indices: ferric reducing ability of plasma (FRAP), total radical-trapping antioxidant parameter (TRAP), and Trolox equivalent antioxidant capacity (TEAC). Multivariable logistic regression was performed to examine the relationship between DTAC and GDM risk in crude and adjusted models.

RESULTS

The mean age and BMI were 28.33 ± 6.23 years and 29.67 ± 4.73 kg/m2, respectively. Total energy, protein, and selenium intakes were significantly higher in cases than controls (P < 0.05). Moreover, intakes of carbohydrate, vitamins C, B6, and A, manganese, fruits, fruit juices, vegetables, legumes, and FRAP were significantly lower in cases than controls (P < 0.05). The risk of gestational diabetes mellitus was 85% lower among those in the highest tertile of FRAP (OR: 0.15; 95% CI: 0.08-0.29). There was no significant association between the risk of GDM and TRAP (OR: 1.62; 95% CI: 0.94-2.79) as well as TEAC (OR: 1.56; 95% CI: 0.89-2.72).

CONCLUSION

Pregnant women who were in the highest tertile of FRAP were at lower risk of GDM. However, larger prospective studies are needed to confirm our findings.

Authors+Show Affiliations

Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran.School of Nutrition, Ryerson University, Toronto, Canada.Department of Community Nutrition, School of Nutritional Science and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Science, Isfahan, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33101589

Citation

Daneshzad, Elnaz, et al. "Dietary Total Antioxidant Capacity and Gestational Diabetes Mellitus: a Case-Control Study." Oxidative Medicine and Cellular Longevity, vol. 2020, 2020, p. 5471316.
Daneshzad E, Tehrani H, Bellissimo N, et al. Dietary Total Antioxidant Capacity and Gestational Diabetes Mellitus: A Case-Control Study. Oxid Med Cell Longev. 2020;2020:5471316.
Daneshzad, E., Tehrani, H., Bellissimo, N., & Azadbakht, L. (2020). Dietary Total Antioxidant Capacity and Gestational Diabetes Mellitus: A Case-Control Study. Oxidative Medicine and Cellular Longevity, 2020, 5471316. https://doi.org/10.1155/2020/5471316
Daneshzad E, et al. Dietary Total Antioxidant Capacity and Gestational Diabetes Mellitus: a Case-Control Study. Oxid Med Cell Longev. 2020;2020:5471316. PubMed PMID: 33101589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary Total Antioxidant Capacity and Gestational Diabetes Mellitus: A Case-Control Study. AU - Daneshzad,Elnaz, AU - Tehrani,Hatav, AU - Bellissimo,Nick, AU - Azadbakht,Leila, Y1 - 2020/10/08/ PY - 2020/04/22/received PY - 2020/08/11/accepted PY - 2020/10/26/entrez PY - 2020/10/27/pubmed PY - 2021/5/14/medline SP - 5471316 EP - 5471316 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2020 N2 - BACKGROUND: Elevated oxidative stress status has been reported among pregnant women with gestational diabetes mellitus (GDM). In diabetic condition, glucose and lipid peroxidation, and alteration in antioxidant defense lead to increased free radicals. The objective of this study was to investigate the association between dietary total antioxidant capacity (DTAC) and GDM. METHODS: This hospital-based case-control study was conducted in 463 pregnant women (healthy, n = 263; GDM, n = 200). Anthropometric indices, blood pressure, and biochemical analyses were measured. Dietary intake was assessed by the average of three 24-hour dietary intake records. DTAC was calculated by three indices: ferric reducing ability of plasma (FRAP), total radical-trapping antioxidant parameter (TRAP), and Trolox equivalent antioxidant capacity (TEAC). Multivariable logistic regression was performed to examine the relationship between DTAC and GDM risk in crude and adjusted models. RESULTS: The mean age and BMI were 28.33 ± 6.23 years and 29.67 ± 4.73 kg/m2, respectively. Total energy, protein, and selenium intakes were significantly higher in cases than controls (P < 0.05). Moreover, intakes of carbohydrate, vitamins C, B6, and A, manganese, fruits, fruit juices, vegetables, legumes, and FRAP were significantly lower in cases than controls (P < 0.05). The risk of gestational diabetes mellitus was 85% lower among those in the highest tertile of FRAP (OR: 0.15; 95% CI: 0.08-0.29). There was no significant association between the risk of GDM and TRAP (OR: 1.62; 95% CI: 0.94-2.79) as well as TEAC (OR: 1.56; 95% CI: 0.89-2.72). CONCLUSION: Pregnant women who were in the highest tertile of FRAP were at lower risk of GDM. However, larger prospective studies are needed to confirm our findings. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/33101589/Dietary_Total_Antioxidant_Capacity_and_Gestational_Diabetes_Mellitus:_A_Case_Control_Study_ L2 - https://doi.org/10.1155/2020/5471316 DB - PRIME DP - Unbound Medicine ER -