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The Distribution and Localization of Collagen Triple Helix Repeat Containing-1 in Naturally and Experimentally Avian Leukosis Virus Subgroup J-Infected Chickens.
Front Vet Sci. 2020; 7:565773.FV

Abstract

Collagen triple helix repeat containing-1 (CTHRC1) has recently been identified as avian leukosis virus subgroup J (ALV-J) replication-dependent factor that remarkably facilitates ALV-J replication via interaction with the envelope glycoprotein (SU) of ALV-J. However, the dynamic distribution and localization of CTHRC1 in various tissues upon ALV-J infection are still unknown. In this study, data revealed that the levels of CTHRC1 were significantly increased in various tissues and that the protein was mainly located in the cytoplasm and nucleus of parenchymal cells in tissues of chickens that were infected by ALV-J naturally and experimentally. Interestingly, CTHRC1 was also observed in leukocytes other than erythrocytes in congested veins of ALV-J-infected tissues. Consequently, the positive cells in these veins were confirmed as lymphocytes by laser confocal microscopy. Taken together, these results conclude that the CTHRC1 is an inducible protein and exhibited ubiquitous expression in ALV-J-infected chickens, which may provide basic information for in-depth study of ALV-J infection and replication mechanisms.

Authors+Show Affiliations

College of Veterinary Medicine, Shandong Agricultural University, Tai'an, China.College of Veterinary Medicine, Shandong Agricultural University, Tai'an, China.College of Veterinary Medicine, Shandong Agricultural University, Tai'an, China.College of Veterinary Medicine, Shandong Agricultural University, Tai'an, China.School of Life Sciences, Qilu Normal University, Jinan, China.College of Veterinary Medicine, Shandong Agricultural University, Tai'an, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33102569

Citation

Pang, Yu, et al. "The Distribution and Localization of Collagen Triple Helix Repeat Containing-1 in Naturally and Experimentally Avian Leukosis Virus Subgroup J-Infected Chickens." Frontiers in Veterinary Science, vol. 7, 2020, p. 565773.
Pang Y, Zhou D, Zhou J, et al. The Distribution and Localization of Collagen Triple Helix Repeat Containing-1 in Naturally and Experimentally Avian Leukosis Virus Subgroup J-Infected Chickens. Front Vet Sci. 2020;7:565773.
Pang, Y., Zhou, D., Zhou, J., Xue, J., Wang, Y., & Cheng, Z. (2020). The Distribution and Localization of Collagen Triple Helix Repeat Containing-1 in Naturally and Experimentally Avian Leukosis Virus Subgroup J-Infected Chickens. Frontiers in Veterinary Science, 7, 565773. https://doi.org/10.3389/fvets.2020.565773
Pang Y, et al. The Distribution and Localization of Collagen Triple Helix Repeat Containing-1 in Naturally and Experimentally Avian Leukosis Virus Subgroup J-Infected Chickens. Front Vet Sci. 2020;7:565773. PubMed PMID: 33102569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Distribution and Localization of Collagen Triple Helix Repeat Containing-1 in Naturally and Experimentally Avian Leukosis Virus Subgroup J-Infected Chickens. AU - Pang,Yu, AU - Zhou,Defang, AU - Zhou,Jing, AU - Xue,Jingwen, AU - Wang,Yiya, AU - Cheng,Ziqiang, Y1 - 2020/09/25/ PY - 2020/05/26/received PY - 2020/08/17/accepted PY - 2020/10/26/entrez PY - 2020/10/27/pubmed PY - 2020/10/27/medline KW - ALV-J KW - Cthrc1 KW - IHC KW - Myelocytomas KW - Poultry SP - 565773 EP - 565773 JF - Frontiers in veterinary science JO - Front Vet Sci VL - 7 N2 - Collagen triple helix repeat containing-1 (CTHRC1) has recently been identified as avian leukosis virus subgroup J (ALV-J) replication-dependent factor that remarkably facilitates ALV-J replication via interaction with the envelope glycoprotein (SU) of ALV-J. However, the dynamic distribution and localization of CTHRC1 in various tissues upon ALV-J infection are still unknown. In this study, data revealed that the levels of CTHRC1 were significantly increased in various tissues and that the protein was mainly located in the cytoplasm and nucleus of parenchymal cells in tissues of chickens that were infected by ALV-J naturally and experimentally. Interestingly, CTHRC1 was also observed in leukocytes other than erythrocytes in congested veins of ALV-J-infected tissues. Consequently, the positive cells in these veins were confirmed as lymphocytes by laser confocal microscopy. Taken together, these results conclude that the CTHRC1 is an inducible protein and exhibited ubiquitous expression in ALV-J-infected chickens, which may provide basic information for in-depth study of ALV-J infection and replication mechanisms. SN - 2297-1769 UR - https://www.unboundmedicine.com/medline/citation/33102569/The_Distribution_and_Localization_of_Collagen_Triple_Helix_Repeat_Containing-1_in_Naturally_and_Experimentally_Avian_Leukosis_Virus_Subgroup_J-Infected_Chickens L2 - https://doi.org/10.3389/fvets.2020.565773 DB - PRIME DP - Unbound Medicine ER -
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