Tags

Type your tag names separated by a space and hit enter

Effects of commonly used food additives on haematological parameters of Wistar rats.
Heliyon. 2020 Oct; 6(10):e05221.H

Abstract

This study was done to investigate the effects of common food additives such as sodium benzoate (SB) and ascorbic acid (AA) on haematological parameters of male Wistar rats. Forty-eight (48) male albino rats with an average weight of 105 g were grouped into twelve (n = 4) of Basal Control and other 11 groups orally administered 1 mg of SB, 10 mg of SB, 10 mg of AA, 0.2 mg of AA + 0.5 mg of SB, 0.2 mg of AA + 1 mg of SB, 0.2 mg of AA + 10 mg of SB, 0.2 mg of SB + 0.1 mg of AA, 0.2 mg of SB + 0.5 mg of AA, carbonated soft drinks (CSD)+ 0.1 mg of AA, CSD + 1 mg of AA and CSD + 10 mg of AA, respectively for 21 non-consecutive days. At the end of the experiment, blood samples were collected in EDTA anticoagulant tubes, haematological parameters were evaluated, and data were analyzed. There was a dose-dependent increase (p < 0.05) in White Blood Cell counts of SB treated rats compared with the control group. The lymphocyte exhibited significant reduction (p < 0.05) in the groups treated with 1mg SB and 10mg SB/kg bodyweight of 67 ± 2.96 and 58 ± 4.18%, respectively. The mean corpuscular haemoglobin showed no significant difference at 95% confidence interval. However, mean corpuscular haemoglobin concentration, haematocrit and platelet were affected by an increase in the concentrations of SB. High SB concentrations increased the destruction of erythrocytes, which directly increased the catabolism of haemoglobin. However, AA administration mitigated the adverse effects of SB on the haematological parameters of the animal.

Authors+Show Affiliations

Department of Animal and Environmental Biology, Adekunle Ajasin University, Akungba-Akoko, Nigeria.Department of Animal and Environmental Biology, Adekunle Ajasin University, Akungba-Akoko, Nigeria.Department of Animal and Environmental Biology, Adekunle Ajasin University, Akungba-Akoko, Nigeria.Department of Animal and Environmental Biology, Adekunle Ajasin University, Akungba-Akoko, Nigeria.Department of Animal and Environmental Biology, Adekunle Ajasin University, Akungba-Akoko, Nigeria.Department of Anatomy, Ekiti State University, Ado-Ekiti, Nigeria.Department of Chemical Sciences, Adekunle Ajasin University, Akungba-Akoko, Nigeria.University of Zululand, South Africa.Department of Animal and Environmental Biology, Adekunle Ajasin University, Akungba-Akoko, Nigeria.Department of Animal and Environmental Biology, Adekunle Ajasin University, Akungba-Akoko, Nigeria.Department of Animal and Environmental Biology, Adekunle Ajasin University, Akungba-Akoko, Nigeria.Department of Animal Science, Adekunle Ajasin University, Akungba-Akoko, Nigeria.Department of Animal and Environmental Biology, Adekunle Ajasin University, Akungba-Akoko, Nigeria.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33102847

Citation

Femi-Oloye, Oluwabunmi Peace, et al. "Effects of Commonly Used Food Additives On Haematological Parameters of Wistar Rats." Heliyon, vol. 6, no. 10, 2020, pp. e05221.
Femi-Oloye OP, Owoloye A, Olatunji-Ojo AM, et al. Effects of commonly used food additives on haematological parameters of Wistar rats. Heliyon. 2020;6(10):e05221.
Femi-Oloye, O. P., Owoloye, A., Olatunji-Ojo, A. M., Abiodun, A. C., Adewumi, B., Ibitoye, B. O., Oloye, F. F., Izegaegbe, J. I., Adebayo, T. M., Adedoja, A. J., Oginni, O. P., Gbore, F. A., & Akinwumi, F. O. (2020). Effects of commonly used food additives on haematological parameters of Wistar rats. Heliyon, 6(10), e05221. https://doi.org/10.1016/j.heliyon.2020.e05221
Femi-Oloye OP, et al. Effects of Commonly Used Food Additives On Haematological Parameters of Wistar Rats. Heliyon. 2020;6(10):e05221. PubMed PMID: 33102847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of commonly used food additives on haematological parameters of Wistar rats. AU - Femi-Oloye,Oluwabunmi Peace, AU - Owoloye,Afolabi, AU - Olatunji-Ojo,Adetola Mary, AU - Abiodun,Adetoye Clement, AU - Adewumi,Bamidele, AU - Ibitoye,Babatunde Oluwaseun, AU - Oloye,Femi Francis, AU - Izegaegbe,Joshua Idowu, AU - Adebayo,Tobi Musa, AU - Adedoja,Ademola Joseph, AU - Oginni,Oyindamola Precious, AU - Gbore,Francis Ayodeji, AU - Akinwumi,Felix Olusegun, Y1 - 2020/10/15/ PY - 2019/05/26/received PY - 2020/05/16/revised PY - 2020/10/08/accepted PY - 2020/10/26/entrez PY - 2020/10/27/pubmed PY - 2020/10/27/medline KW - Ascorbic acid KW - Fanta KW - Food science KW - Haematology KW - Natural product chemistry KW - Sodium benzoate KW - Wistar rats SP - e05221 EP - e05221 JF - Heliyon JO - Heliyon VL - 6 IS - 10 N2 - This study was done to investigate the effects of common food additives such as sodium benzoate (SB) and ascorbic acid (AA) on haematological parameters of male Wistar rats. Forty-eight (48) male albino rats with an average weight of 105 g were grouped into twelve (n = 4) of Basal Control and other 11 groups orally administered 1 mg of SB, 10 mg of SB, 10 mg of AA, 0.2 mg of AA + 0.5 mg of SB, 0.2 mg of AA + 1 mg of SB, 0.2 mg of AA + 10 mg of SB, 0.2 mg of SB + 0.1 mg of AA, 0.2 mg of SB + 0.5 mg of AA, carbonated soft drinks (CSD)+ 0.1 mg of AA, CSD + 1 mg of AA and CSD + 10 mg of AA, respectively for 21 non-consecutive days. At the end of the experiment, blood samples were collected in EDTA anticoagulant tubes, haematological parameters were evaluated, and data were analyzed. There was a dose-dependent increase (p < 0.05) in White Blood Cell counts of SB treated rats compared with the control group. The lymphocyte exhibited significant reduction (p < 0.05) in the groups treated with 1mg SB and 10mg SB/kg bodyweight of 67 ± 2.96 and 58 ± 4.18%, respectively. The mean corpuscular haemoglobin showed no significant difference at 95% confidence interval. However, mean corpuscular haemoglobin concentration, haematocrit and platelet were affected by an increase in the concentrations of SB. High SB concentrations increased the destruction of erythrocytes, which directly increased the catabolism of haemoglobin. However, AA administration mitigated the adverse effects of SB on the haematological parameters of the animal. SN - 2405-8440 UR - https://www.unboundmedicine.com/medline/citation/33102847/Effects_of_commonly_used_food_additives_on_haematological_parameters_of_Wistar_rats L2 - https://linkinghub.elsevier.com/retrieve/pii/S2405-8440(20)32064-8 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.