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Gut mucosa in the rats exposed temporary mechanical obstruction fed with probiotic.
Ulus Travma Acil Cerrahi Derg. 2020 Oct; 26(6):833-842.UT

Abstract

BACKGROUND

Created a model in the rats, to prevent mucosal damage and related effects in the patients, who were operated due to mechanical obstruction. Some groups fed fodder with probiotics, some groups fed with standard fodder. It is objected that the damage of gut mucosa and related effects on how to expose the differences of the groups.

METHODS

In this study, 48 female Wistar-albino type rats are separated into five groups randomly. In the first operation, rats' terminal ileum was tied up with silk except for the control group. Two groups 24, the other two groups 48 hours later operated again and terminal ileum obstructions were removed. During that time, each one of those 24 and 48 hours of obstructed groups were fed with probiotic. Twenty-four hours later, the control group and other groups were operated for the third time for sampling. Terminal ileum, liver, spleen, MLN (Mesenteric lymph node) and blood samples were taken.

RESULTS

The research group, which was obstructed and fed with probiotics during 48 hours, was significantly observed in increased mucosa cell loss and mucosal edema. Bacterial translocation was found more common in groups without probiotics. Tissue GR (Glutathione reductase) and erythrocyte CAT (Catalase) were lower in the group of 24 hours obstructed and given probiotics.

CONCLUSION

The findings suggest that the high rate of mucosal edemas in the groups that are fed with probiotics can be seen as damage, but we think that probiotics are consonant with the strength of the mucosal barrier. Thus, in the groups fed with probiotics, it is possible that bacterial translocation is seen less, and some antioxidative enzymes are found less. Further studies are needed to investigate the benefits of probiotics in patients operated for obstruction.

Authors+Show Affiliations

Departmant of General Surgery, Surgical Oncology, Mersin University Faculty of Medicine, Mersin-Turkey.Departmant of General Surgery, Adnan Menderes University Faculty of Medicine, Aydın-Turkey.Departmant of General Surgery, Adnan Menderes University Faculty of Medicine, Aydın-Turkey.Departmant of Biochemistry, Adnan Menderes University Faculty of Medicine, Aydın-Turkey.Departmant of Infectious Diseases, Adnan Menderes University Faculty of Medicine, Aydın-Turkey.Departmant of Pathology, Adnan Menderes University Faculty of Medicine, Aydın-Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33107959

Citation

Edizsoy, Akay, et al. "Gut Mucosa in the Rats Exposed Temporary Mechanical Obstruction Fed With Probiotic." Ulusal Travma Ve Acil Cerrahi Dergisi = Turkish Journal of Trauma & Emergency Surgery : TJTES, vol. 26, no. 6, 2020, pp. 833-842.
Edizsoy A, Yılmaz E, Çevikel MH, et al. Gut mucosa in the rats exposed temporary mechanical obstruction fed with probiotic. Ulus Travma Acil Cerrahi Derg. 2020;26(6):833-842.
Edizsoy, A., Yılmaz, E., Çevikel, M. H., Yenisey, Ç., Sakarya, S., & Meteoğlu, İ. (2020). Gut mucosa in the rats exposed temporary mechanical obstruction fed with probiotic. Ulusal Travma Ve Acil Cerrahi Dergisi = Turkish Journal of Trauma & Emergency Surgery : TJTES, 26(6), 833-842. https://doi.org/10.14744/tjtes.2020.30269
Edizsoy A, et al. Gut Mucosa in the Rats Exposed Temporary Mechanical Obstruction Fed With Probiotic. Ulus Travma Acil Cerrahi Derg. 2020;26(6):833-842. PubMed PMID: 33107959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gut mucosa in the rats exposed temporary mechanical obstruction fed with probiotic. AU - Edizsoy,Akay, AU - Yılmaz,Eyüp, AU - Çevikel,Mehmet Hakan, AU - Yenisey,Çiğdem, AU - Sakarya,Serhan, AU - Meteoğlu,İbrahim, PY - 2020/10/27/entrez PY - 2020/10/28/pubmed PY - 2020/10/28/medline SP - 833 EP - 842 JF - Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES JO - Ulus Travma Acil Cerrahi Derg VL - 26 IS - 6 N2 - BACKGROUND: Created a model in the rats, to prevent mucosal damage and related effects in the patients, who were operated due to mechanical obstruction. Some groups fed fodder with probiotics, some groups fed with standard fodder. It is objected that the damage of gut mucosa and related effects on how to expose the differences of the groups. METHODS: In this study, 48 female Wistar-albino type rats are separated into five groups randomly. In the first operation, rats' terminal ileum was tied up with silk except for the control group. Two groups 24, the other two groups 48 hours later operated again and terminal ileum obstructions were removed. During that time, each one of those 24 and 48 hours of obstructed groups were fed with probiotic. Twenty-four hours later, the control group and other groups were operated for the third time for sampling. Terminal ileum, liver, spleen, MLN (Mesenteric lymph node) and blood samples were taken. RESULTS: The research group, which was obstructed and fed with probiotics during 48 hours, was significantly observed in increased mucosa cell loss and mucosal edema. Bacterial translocation was found more common in groups without probiotics. Tissue GR (Glutathione reductase) and erythrocyte CAT (Catalase) were lower in the group of 24 hours obstructed and given probiotics. CONCLUSION: The findings suggest that the high rate of mucosal edemas in the groups that are fed with probiotics can be seen as damage, but we think that probiotics are consonant with the strength of the mucosal barrier. Thus, in the groups fed with probiotics, it is possible that bacterial translocation is seen less, and some antioxidative enzymes are found less. Further studies are needed to investigate the benefits of probiotics in patients operated for obstruction. SN - 1306-696X UR - https://www.unboundmedicine.com/medline/citation/33107959/Gut_mucosa_in_the_rats_exposed_temporary_mechanical_obstruction_fed_with_probiotic L2 - http://www.journalagent.com/pubmed/linkout.asp?ISSN=1306-696X&PMID=33107959 DB - PRIME DP - Unbound Medicine ER -
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