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Short-term oral administration of non-porous and mesoporous silica did not induce local or systemic toxicity in mice.
Nanotoxicology. 2020 Oct 28 [Online ahead of print]N

Abstract

In this study, two sets of methyl-coated non-porous and mesoporous amorphous silica materials of two target sizes (100 and 300 nm; 10-844 m2/g) were used to investigate the potential role of specific surface area (SSA) and porosity on the oral toxicity in mice. Female Swiss mice were administered by oral gavage for 5 consecutive days. Two silica dose levels (100 and 1000 mg/kg b.w.) were tested for all four materials. All dispersions were characterized by transmission electron microscopy (TEM) and Nanoparticle tracking analysis (NTA). Batch dispersions of porous silica were rather unstable due to agglomeration. Animals were sacrificed one day after the last administration or after a three-week recovery period. No relevant toxicological effects were induced by any of the silica materials tested, as evaluated by body weight, gross pathology, relative organ weights (liver, spleen, kidneys), hematology, blood biochemistry, genotoxicity (Comet assay in jejunum cells and micronucleus test in peripheral blood erythrocytes), liver and small intestine histopathology, and intestinal inflammation. The presence of silica particles in the intestine was evaluated by a hyperspectral imaging microscopy system (CytoViva) using histological samples of jejunum tissue. Silica spectral signatures were found in jejunum samples with all the treatments, but only statistically significant in one of the treatment groups.

Authors+Show Affiliations

Leitat Technological Center, Terrassa, Spain.Leitat Technological Center, Terrassa, Spain.Finnish Institute of Occupational Health, Helsinki, Finland. Department of Anatomy, Embryology and Genetics, University of Zaragoza, Zaragoza, Spain.Finnish Institute of Occupational Health, Helsinki, Finland. Finnish Safety and Chemicals Agency, Helsinki, Finland.Finnish Institute of Occupational Health, Helsinki, Finland.Leitat Technological Center, Terrassa, Spain.Leitat Technological Center, Terrassa, Spain.The National Research Centre for the Working Environment, Copenhague, Denmark.The National Research Centre for the Working Environment, Copenhague, Denmark. INFINGENT Innovations AB, Medeon Science Park, Malmö, Sweden.Leitat Technological Center, Terrassa, Spain.Leitat Technological Center, Terrassa, Spain.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33108958

Citation

Cabellos, Joan, et al. "Short-term Oral Administration of Non-porous and Mesoporous Silica Did Not Induce Local or Systemic Toxicity in Mice." Nanotoxicology, 2020, pp. 1-18.
Cabellos J, Gimeno-Benito I, Catalán J, et al. Short-term oral administration of non-porous and mesoporous silica did not induce local or systemic toxicity in mice. Nanotoxicology. 2020.
Cabellos, J., Gimeno-Benito, I., Catalán, J., Lindberg, H. K., Vales, G., Fernandez-Rosas, E., Ghemis, R., Jensen, K. A., Atluri, R., Vázquez-Campos, S., & Janer, G. (2020). Short-term oral administration of non-porous and mesoporous silica did not induce local or systemic toxicity in mice. Nanotoxicology, 1-18. https://doi.org/10.1080/17435390.2020.1818325
Cabellos J, et al. Short-term Oral Administration of Non-porous and Mesoporous Silica Did Not Induce Local or Systemic Toxicity in Mice. Nanotoxicology. 2020 Oct 28;1-18. PubMed PMID: 33108958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term oral administration of non-porous and mesoporous silica did not induce local or systemic toxicity in mice. AU - Cabellos,Joan, AU - Gimeno-Benito,Irene, AU - Catalán,Julia, AU - Lindberg,Hanna K, AU - Vales,Gerard, AU - Fernandez-Rosas,Elisabet, AU - Ghemis,Radu, AU - Jensen,Keld A, AU - Atluri,Rambabu, AU - Vázquez-Campos,Socorro, AU - Janer,Gemma, Y1 - 2020/10/28/ PY - 2020/10/28/entrez PY - 2020/10/29/pubmed PY - 2020/10/29/medline KW - in vivo KW - Synthetic amorphous silica KW - genotoxicity KW - oral toxicity SP - 1 EP - 18 JF - Nanotoxicology JO - Nanotoxicology N2 - In this study, two sets of methyl-coated non-porous and mesoporous amorphous silica materials of two target sizes (100 and 300 nm; 10-844 m2/g) were used to investigate the potential role of specific surface area (SSA) and porosity on the oral toxicity in mice. Female Swiss mice were administered by oral gavage for 5 consecutive days. Two silica dose levels (100 and 1000 mg/kg b.w.) were tested for all four materials. All dispersions were characterized by transmission electron microscopy (TEM) and Nanoparticle tracking analysis (NTA). Batch dispersions of porous silica were rather unstable due to agglomeration. Animals were sacrificed one day after the last administration or after a three-week recovery period. No relevant toxicological effects were induced by any of the silica materials tested, as evaluated by body weight, gross pathology, relative organ weights (liver, spleen, kidneys), hematology, blood biochemistry, genotoxicity (Comet assay in jejunum cells and micronucleus test in peripheral blood erythrocytes), liver and small intestine histopathology, and intestinal inflammation. The presence of silica particles in the intestine was evaluated by a hyperspectral imaging microscopy system (CytoViva) using histological samples of jejunum tissue. Silica spectral signatures were found in jejunum samples with all the treatments, but only statistically significant in one of the treatment groups. SN - 1743-5404 UR - https://www.unboundmedicine.com/medline/citation/33108958/Short-term_oral_administration_of_non-porous_and_mesoporous_silica_did_not_induce_local_or_systemic_toxicity_in_mice L2 - http://www.tandfonline.com/doi/full/10.1080/17435390.2020.1818325 DB - PRIME DP - Unbound Medicine ER -
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