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Spur Cells Causing Severe and Transfusion-Refractory Anemia in Patients With Acute-on-Chronic Liver Failure.
Cureus. 2020 Sep 21; 12(9):e10568.C

Abstract

Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation of chronic liver disease associated with organ failures. Anemia of diverse etiology is common in patients with ACLF. Spur cell anemia (SCA) is a form of acquired hemolytic anemia that occurs rarely in such patients due to dysregulated lipids metabolism. Spur cells are large erythrocytes with spike-like projections, which predispose them for sequestration and destruction in splenic canaliculi. There is a paucity of data on SCA in patients with ACLF. Here we report a series of five ACLF patients who had severe (hemoglobin level < 8 g/dL) and transfusion-refractory SCA with aggressive clinical course and high mortality rate.

Authors+Show Affiliations

Hepatology, Sri Ramachandra Institute of Higher Education and Research, Chennai, IND.Gastroenterology, All India Institute of Medical Sciences, Patna, IND.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

33110713

Citation

Kedarisetty, Chandan Kumar, and Ramesh Kumar. "Spur Cells Causing Severe and Transfusion-Refractory Anemia in Patients With Acute-on-Chronic Liver Failure." Cureus, vol. 12, no. 9, 2020, pp. e10568.
Kedarisetty CK, Kumar R. Spur Cells Causing Severe and Transfusion-Refractory Anemia in Patients With Acute-on-Chronic Liver Failure. Cureus. 2020;12(9):e10568.
Kedarisetty, C. K., & Kumar, R. (2020). Spur Cells Causing Severe and Transfusion-Refractory Anemia in Patients With Acute-on-Chronic Liver Failure. Cureus, 12(9), e10568. https://doi.org/10.7759/cureus.10568
Kedarisetty CK, Kumar R. Spur Cells Causing Severe and Transfusion-Refractory Anemia in Patients With Acute-on-Chronic Liver Failure. Cureus. 2020 Sep 21;12(9):e10568. PubMed PMID: 33110713.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spur Cells Causing Severe and Transfusion-Refractory Anemia in Patients With Acute-on-Chronic Liver Failure. AU - Kedarisetty,Chandan Kumar, AU - Kumar,Ramesh, Y1 - 2020/09/21/ PY - 2020/10/28/entrez PY - 2020/10/29/pubmed PY - 2020/10/29/medline KW - acanthocytes KW - aclf KW - alcohol KW - anemia KW - cirrhosis SP - e10568 EP - e10568 JF - Cureus JO - Cureus VL - 12 IS - 9 N2 - Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation of chronic liver disease associated with organ failures. Anemia of diverse etiology is common in patients with ACLF. Spur cell anemia (SCA) is a form of acquired hemolytic anemia that occurs rarely in such patients due to dysregulated lipids metabolism. Spur cells are large erythrocytes with spike-like projections, which predispose them for sequestration and destruction in splenic canaliculi. There is a paucity of data on SCA in patients with ACLF. Here we report a series of five ACLF patients who had severe (hemoglobin level < 8 g/dL) and transfusion-refractory SCA with aggressive clinical course and high mortality rate. SN - 2168-8184 UR - https://www.unboundmedicine.com/medline/citation/33110713/Spur_Cells_Causing_Severe_and_Transfusion-Refractory_Anemia_in_Patients_With_Acute-on-Chronic_Liver_Failure L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/33110713/ DB - PRIME DP - Unbound Medicine ER -
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