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Hematologic parameters in coronavirus infection (COVID-19) and their clinical implications.
Discoveries (Craiova). 2020 Oct 01; 8(4):e117.D

Abstract

Coronaviruses are a class of enveloped RNA viruses that cause infections of the respiratory tract, characterized by fever, tiredness, dry cough, diarrhea, loss of smell or taste, chest pain and shortness of breath. Many patients with mysterious pneumonia were distinguished in December 2019 in Wuhan. The pneumonia of obscure origin was found to be ascribed to a novel coronavirus and described as novel coronavirus pneumonia (NCP). The Chinese authorities initially reported the wave of mysterious pneumonia on December 31st, 2019 and it was declared as an outbreak of international concern on January 30th, 2020. A systematic search of relevant research was conducted, and a total of 58 primary research articles were identified, analyzed, and debated to better understand the hematologic profile in COVID-19 (Coronavirus disease) infection and its clinical implications. All the findings in this article manifest a true impression of the current interpretation of hematological findings of the SARS-COV-2 disease. Pathophysiology of COVID-19 disease can be better interpreted by taking into consideration the hematologic parameters. Clinical implications of the hematologic profile of COVID-19 patients including cytokine storm, coagulation profile, and thrombophilic complications are under-recognized. Therefore, this review focuses on the coagulation profile, cytokine storm, and its treatment options. The role of pre-existing thrombophilia in COVID-19 patients and how it could result in the poor prognosis of the disease is also debated. The recent data suggests that hypercoagulability could be the potential cause of fatalities due to COVID-19. Potential effects of tocilizumab, metronidazole, and ulinastatin in suppressing cytokine storm may help to treat SARS-COV-2 infection. This review also highlights the significance of thrombophilia testing in SARS-CoV-2 patients depending on the clinical features and especially in pregnant women.

Authors+Show Affiliations

CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan.CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan. California Institute of Behavioral Neurosciences & Psychology, Fairfield, CA 94534, USA.CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan.CMH Lahore Medical College and Institute of Dentistry, Lahore, Pakistan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33110936

Citation

Waleed, Rao Muhammad, et al. "Hematologic Parameters in Coronavirus Infection (COVID-19) and Their Clinical Implications." Discoveries (Craiova, Romania), vol. 8, no. 4, 2020, pp. e117.
Waleed RM, Iftikhar W, Sehar I, et al. Hematologic parameters in coronavirus infection (COVID-19) and their clinical implications. Discoveries (Craiova). 2020;8(4):e117.
Waleed, R. M., Iftikhar, W., Sehar, I., & Khan, H. S. (2020). Hematologic parameters in coronavirus infection (COVID-19) and their clinical implications. Discoveries (Craiova, Romania), 8(4), e117. https://doi.org/10.15190/d.2020.14
Waleed RM, et al. Hematologic Parameters in Coronavirus Infection (COVID-19) and Their Clinical Implications. Discoveries (Craiova). 2020 Oct 1;8(4):e117. PubMed PMID: 33110936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hematologic parameters in coronavirus infection (COVID-19) and their clinical implications. AU - Waleed,Rao Muhammad, AU - Iftikhar,Waleed, AU - Sehar,Inbisat, AU - Khan,Huma Saeed, Y1 - 2020/10/01/ PY - 2020/10/28/entrez PY - 2020/10/29/pubmed PY - 2020/10/29/medline KW - COVID-19 KW - Coronavirus KW - D-dimer KW - coagulopathy KW - cytokine storm KW - pneumonia of unknown origin KW - thrombophilia SP - e117 EP - e117 JF - Discoveries (Craiova, Romania) JO - Discoveries (Craiova) VL - 8 IS - 4 N2 - Coronaviruses are a class of enveloped RNA viruses that cause infections of the respiratory tract, characterized by fever, tiredness, dry cough, diarrhea, loss of smell or taste, chest pain and shortness of breath. Many patients with mysterious pneumonia were distinguished in December 2019 in Wuhan. The pneumonia of obscure origin was found to be ascribed to a novel coronavirus and described as novel coronavirus pneumonia (NCP). The Chinese authorities initially reported the wave of mysterious pneumonia on December 31st, 2019 and it was declared as an outbreak of international concern on January 30th, 2020. A systematic search of relevant research was conducted, and a total of 58 primary research articles were identified, analyzed, and debated to better understand the hematologic profile in COVID-19 (Coronavirus disease) infection and its clinical implications. All the findings in this article manifest a true impression of the current interpretation of hematological findings of the SARS-COV-2 disease. Pathophysiology of COVID-19 disease can be better interpreted by taking into consideration the hematologic parameters. Clinical implications of the hematologic profile of COVID-19 patients including cytokine storm, coagulation profile, and thrombophilic complications are under-recognized. Therefore, this review focuses on the coagulation profile, cytokine storm, and its treatment options. The role of pre-existing thrombophilia in COVID-19 patients and how it could result in the poor prognosis of the disease is also debated. The recent data suggests that hypercoagulability could be the potential cause of fatalities due to COVID-19. Potential effects of tocilizumab, metronidazole, and ulinastatin in suppressing cytokine storm may help to treat SARS-COV-2 infection. This review also highlights the significance of thrombophilia testing in SARS-CoV-2 patients depending on the clinical features and especially in pregnant women. SN - 2359-7232 UR - https://www.unboundmedicine.com/medline/citation/33110936/Hematologic_parameters_in_coronavirus_infection_(COVID-19)_and_their_clinical_implications L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/33110936/ DB - PRIME DP - Unbound Medicine ER -
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