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Characterization and impact of respiratory microbiota on viral infections.
Virologie (Montrouge). 2018 Jun 01; 22(3):161-172.V

Abstract

Considered for years as sterile, respiratory tract contains very variable bacterial microbiome. Driven by next generation sequencing techniques, microbiome analyses allow a better understanding of viral infection pathophysiology, in terms of incidence and lethality. After a short reminder of microbiome characterization methods, this review will describe its impact on adaptive and innate immunity of the infected host. Studied by viral challenges after antibiotic administration, microbiome depletion has an important impact on clinical outcome of the host. Patient's management and therapeutic choices could exploit results of this field of research, using microbiome characteristics as prognostic biomarkers. Numerous immunologic pathways are impacted by modification of the microbiome and its restoration, using probiotic or innovative molecules could confer better clinical prognostic of viral respiratory diseases.

Authors+Show Affiliations

Centre hospitalier universitaire de Lyon, Laboratoire de virologie, Institut des agents infectieux (IAI) de Lyon, Centre national de référence des virus respiratoires France Sud, Centre de biologie et de pathologie Nord, Groupement hospitalier Nord F-69317, Lyon cedex 04, France Université Claude Bernard Lyon 1, Faculté de médecine Lyon Est, CIRI, ENS, Inserm U1111 CNRS UMR5308, équipe Virpath, F-69372, Lyon cedex 08, France.Centre hospitalier universitaire de Lyon, Laboratoire de virologie, Institut des agents infectieux (IAI) de Lyon, Centre national de référence des virus respiratoires France Sud, Centre de biologie et de pathologie Nord, Groupement hospitalier Nord F-69317, Lyon cedex 04, France Université Claude Bernard Lyon 1, Faculté de médecine Lyon Est, CIRI, ENS, Inserm U1111 CNRS UMR5308, équipe Virpath, F-69372, Lyon cedex 08, France.Centre hospitalier universitaire de Lyon, Laboratoire de virologie, Institut des agents infectieux (IAI) de Lyon, Centre national de référence des virus respiratoires France Sud, Centre de biologie et de pathologie Nord, Groupement hospitalier Nord F-69317, Lyon cedex 04, France Université Claude Bernard Lyon 1, Faculté de médecine Lyon Est, CIRI, ENS, Inserm U1111 CNRS UMR5308, équipe Virpath, F-69372, Lyon cedex 08, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33111673

Citation

Pichon, Maxime, et al. "Characterization and Impact of Respiratory Microbiota On Viral Infections." Virologie (Montrouge, France), vol. 22, no. 3, 2018, pp. 161-172.
Pichon M, Lina B, Josset L. Characterization and impact of respiratory microbiota on viral infections. Virologie (Montrouge). 2018;22(3):161-172.
Pichon, M., Lina, B., & Josset, L. (2018). Characterization and impact of respiratory microbiota on viral infections. Virologie (Montrouge, France), 22(3), 161-172. https://doi.org/10.1684/vir.2018.0739
Pichon M, Lina B, Josset L. Characterization and Impact of Respiratory Microbiota On Viral Infections. Virologie (Montrouge). 2018 Jun 1;22(3):161-172. PubMed PMID: 33111673.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization and impact of respiratory microbiota on viral infections. AU - Pichon,Maxime, AU - Lina,Bruno, AU - Josset,Laurence, PY - 2020/10/28/entrez PY - 2018/6/1/pubmed PY - 2018/6/1/medline KW - 16S DNA KW - NGS KW - metagenomic KW - respiratory microbiome KW - viral infections SP - 161 EP - 172 JF - Virologie (Montrouge, France) JO - Virologie (Montrouge) VL - 22 IS - 3 N2 - Considered for years as sterile, respiratory tract contains very variable bacterial microbiome. Driven by next generation sequencing techniques, microbiome analyses allow a better understanding of viral infection pathophysiology, in terms of incidence and lethality. After a short reminder of microbiome characterization methods, this review will describe its impact on adaptive and innate immunity of the infected host. Studied by viral challenges after antibiotic administration, microbiome depletion has an important impact on clinical outcome of the host. Patient's management and therapeutic choices could exploit results of this field of research, using microbiome characteristics as prognostic biomarkers. Numerous immunologic pathways are impacted by modification of the microbiome and its restoration, using probiotic or innovative molecules could confer better clinical prognostic of viral respiratory diseases. SN - 1267-8694 UR - https://www.unboundmedicine.com/medline/citation/33111673/Characterization_and_impact_of_respiratory_microbiota_on_viral_infections DB - PRIME DP - Unbound Medicine ER -
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