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SARS-CoV-2 evades immune detection in alveolar macrophages.
EMBO Rep. 2020 Oct 28 [Online ahead of print]ER

Abstract

Respiratory infections, like the current COVID-19 pandemic, target epithelial cells in the respiratory tract. Alveolar macrophages (AMs) are tissue-resident macrophages located within the lung. They play a key role in the early phases of an immune response to respiratory viruses. AMs are likely the first immune cells to encounter SARS-CoV-2 during an infection, and their reaction to the virus will have a profound impact on the outcome of the infection. Interferons (IFNs) are antiviral cytokines and among the first cytokines produced upon viral infection. In this study, AMs from non-infectious donors are challenged with SARS-CoV-2. We demonstrate that challenged AMs are incapable of sensing SARS-CoV-2 and of producing an IFN response in contrast to other respiratory viruses, like influenza A virus and Sendai virus, which trigger a robust IFN response. The absence of IFN production in AMs upon challenge with SARS-CoV-2 could explain the initial asymptotic phase observed during COVID-19 and argues against AMs being the sources of pro-inflammatory cytokines later during infection.

Authors+Show Affiliations

Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.Department of Biomedicine, Aarhus University, Aarhus, Denmark.Department of Biomedicine, Aarhus University, Aarhus, Denmark.Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.Department of Biomedicine, Aarhus University, Aarhus, Denmark.Department of Biomedicine, Aarhus University, Aarhus, Denmark.Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark. Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.Department of Biomedicine, Aarhus University, Aarhus, Denmark.Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33112036

Citation

Dalskov, Louise, et al. "SARS-CoV-2 Evades Immune Detection in Alveolar Macrophages." EMBO Reports, 2020, pp. e51252.
Dalskov L, Møhlenberg M, Thyrsted J, et al. SARS-CoV-2 evades immune detection in alveolar macrophages. EMBO Rep. 2020.
Dalskov, L., Møhlenberg, M., Thyrsted, J., Blay-Cadanet, J., Poulsen, E. T., Folkersen, B. H., Skaarup, S. H., Olagnier, D., Reinert, L., Enghild, J. J., Hoffmann, H. J., Holm, C. K., & Hartmann, R. (2020). SARS-CoV-2 evades immune detection in alveolar macrophages. EMBO Reports, e51252. https://doi.org/10.15252/embr.202051252
Dalskov L, et al. SARS-CoV-2 Evades Immune Detection in Alveolar Macrophages. EMBO Rep. 2020 Oct 28;e51252. PubMed PMID: 33112036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2 evades immune detection in alveolar macrophages. AU - Dalskov,Louise, AU - Møhlenberg,Michelle, AU - Thyrsted,Jacob, AU - Blay-Cadanet,Julia, AU - Poulsen,Ebbe Toftgaard, AU - Folkersen,Birgitte Holst, AU - Skaarup,Søren Helbo, AU - Olagnier,David, AU - Reinert,Line, AU - Enghild,Jan Johannes, AU - Hoffmann,Hans Jürgen, AU - Holm,Christian Kanstrup, AU - Hartmann,Rune, Y1 - 2020/10/28/ PY - 2020/07/07/received PY - 2020/09/27/revised PY - 2020/09/30/accepted PY - 2020/10/28/entrez PY - 2020/10/29/pubmed PY - 2020/10/29/medline KW - COVID-19 KW - SARS-CoV-2 KW - alveolar macrophages KW - interferon KW - interferon lambda SP - e51252 EP - e51252 JF - EMBO reports JO - EMBO Rep N2 - Respiratory infections, like the current COVID-19 pandemic, target epithelial cells in the respiratory tract. Alveolar macrophages (AMs) are tissue-resident macrophages located within the lung. They play a key role in the early phases of an immune response to respiratory viruses. AMs are likely the first immune cells to encounter SARS-CoV-2 during an infection, and their reaction to the virus will have a profound impact on the outcome of the infection. Interferons (IFNs) are antiviral cytokines and among the first cytokines produced upon viral infection. In this study, AMs from non-infectious donors are challenged with SARS-CoV-2. We demonstrate that challenged AMs are incapable of sensing SARS-CoV-2 and of producing an IFN response in contrast to other respiratory viruses, like influenza A virus and Sendai virus, which trigger a robust IFN response. The absence of IFN production in AMs upon challenge with SARS-CoV-2 could explain the initial asymptotic phase observed during COVID-19 and argues against AMs being the sources of pro-inflammatory cytokines later during infection. SN - 1469-3178 UR - https://www.unboundmedicine.com/medline/citation/33112036/SARS-CoV-2_evades_immune_detection_in_alveolar_macrophages L2 - https://doi.org/10.15252/embr.202051252 DB - PRIME DP - Unbound Medicine ER -
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