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Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19.
Am J Physiol Lung Cell Mol Physiol. 2021 01 01; 320(1):L152-L157.AJ

Abstract

The COVID-19 pandemic is associated with severe pneumonia and acute respiratory distress syndrome leading to death in susceptible individuals. For those who recover, post-COVID-19 complications may include development of pulmonary fibrosis. Factors contributing to disease severity or development of complications are not known. Using computational analysis with experimental data, we report that idiopathic pulmonary fibrosis (IPF)- and chronic obstructive pulmonary disease (COPD)-derived lung fibroblasts express higher levels of angiotensin-converting enzyme 2 (ACE2), the receptor for SARS-CoV-2 entry and part of the renin-angiotensin system that is antifibrotic and anti-inflammatory. In preclinical models, we found that chronic exposure to cigarette smoke, a risk factor for both COPD and IPF and potentially for SARS-CoV-2 infection, significantly increased pulmonary ACE2 protein expression. Further studies are needed to understand the functional implications of ACE2 on lung fibroblasts, a cell type that thus far has received relatively little attention in the context of COVID-19.

Authors+Show Affiliations

Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada. Department of Pathology, McGill University, Montreal, Quebec, Canada.Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada. Department of Computational Biology, Carnegie Mellon University, Pittsburgh, Pennsylvania.Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada. Department of Medicine, McGill University, Montreal, Quebec, Canada.Department of Medicine, McMaster University & St. Joseph's Healthcare, Hamilton, Ontario, Canada.Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada. Department of Pathology, McGill University, Montreal, Quebec, Canada.Department of Medicine, McGill University, Montreal, Quebec, Canada.Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada. Department of Pathology, McGill University, Montreal, Quebec, Canada. Department of Medicine, McGill University, Montreal, Quebec, Canada. Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33112187

Citation

Aloufi, Noof, et al. "Angiotensin-converting Enzyme 2 Expression in COPD and IPF Fibroblasts: the Forgotten Cell in COVID-19." American Journal of Physiology. Lung Cellular and Molecular Physiology, vol. 320, no. 1, 2021, pp. L152-L157.
Aloufi N, Traboulsi H, Ding J, et al. Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19. Am J Physiol Lung Cell Mol Physiol. 2021;320(1):L152-L157.
Aloufi, N., Traboulsi, H., Ding, J., Fonseca, G. J., Nair, P., Huang, S. K., Hussain, S. N. A., Eidelman, D. H., & Baglole, C. J. (2021). Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19. American Journal of Physiology. Lung Cellular and Molecular Physiology, 320(1), L152-L157. https://doi.org/10.1152/ajplung.00455.2020
Aloufi N, et al. Angiotensin-converting Enzyme 2 Expression in COPD and IPF Fibroblasts: the Forgotten Cell in COVID-19. Am J Physiol Lung Cell Mol Physiol. 2021 01 1;320(1):L152-L157. PubMed PMID: 33112187.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19. AU - Aloufi,Noof, AU - Traboulsi,Hussein, AU - Ding,Jun, AU - Fonseca,Gregory J, AU - Nair,Parameswaran, AU - Huang,Steven K, AU - Hussain,Sabah N A, AU - Eidelman,David H, AU - Baglole,Carolyn J, Y1 - 2020/10/28/ PY - 2020/10/29/pubmed PY - 2021/2/10/medline PY - 2020/10/28/entrez KW - ACE2 KW - COPD KW - IPF KW - SARS-CoV-2 KW - fibroblast SP - L152 EP - L157 JF - American journal of physiology. Lung cellular and molecular physiology JO - Am J Physiol Lung Cell Mol Physiol VL - 320 IS - 1 N2 - The COVID-19 pandemic is associated with severe pneumonia and acute respiratory distress syndrome leading to death in susceptible individuals. For those who recover, post-COVID-19 complications may include development of pulmonary fibrosis. Factors contributing to disease severity or development of complications are not known. Using computational analysis with experimental data, we report that idiopathic pulmonary fibrosis (IPF)- and chronic obstructive pulmonary disease (COPD)-derived lung fibroblasts express higher levels of angiotensin-converting enzyme 2 (ACE2), the receptor for SARS-CoV-2 entry and part of the renin-angiotensin system that is antifibrotic and anti-inflammatory. In preclinical models, we found that chronic exposure to cigarette smoke, a risk factor for both COPD and IPF and potentially for SARS-CoV-2 infection, significantly increased pulmonary ACE2 protein expression. Further studies are needed to understand the functional implications of ACE2 on lung fibroblasts, a cell type that thus far has received relatively little attention in the context of COVID-19. SN - 1522-1504 UR - https://www.unboundmedicine.com/medline/citation/33112187/Angiotensin_converting_enzyme_2_expression_in_COPD_and_IPF_fibroblasts:_the_forgotten_cell_in_COVID_19_ L2 - https://journals.physiology.org/doi/10.1152/ajplung.00455.2020?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -