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A double-blind trial of a fixed combination of mefloquine plus sulfadoxine-pyrimethamine compared with sulfadoxine-pyrimethamine alone in symptomatic falciparum malaria.
Bull World Health Organ. 1987; 65(3):369-73.BW

Abstract

A total of 100 male Zambian patients with symptomatic falciparum malaria were treated with either two tablets of mefloquine plus sulfadoxine-pyrimethamine (Fansimef) or three tablets of sulfadoxine-pyrimethamine (Fansidar) as a single dose. The patients were kept under observation from day 0 (day of treatment) to day 28 and all were cured. An S-type of response was seen in all patients; one patient in the Fansimef group inexplicably remained positive for Plasmodium falciparum trophozoites until day 6. There were no cases of recrudescence.The rate of clearance of parasitaemia was similar in both groups. The rate of clearance of fever was marginally faster in the Fansimef group. Side-effects such as pruritus, diarrhoea and abdominal pain occurred after both drugs but were mild and transient; tolerance was slightly better with Fansimef. Severe orthostatic hypotension occurred in 20% of the Fansidar patients and in only 2% of the Fansimef patients; this was reversed by bed rest. Haematological and biochemical parameters were generally not modified in an undesirable manner by the administration of these drugs.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3311440

Citation

Ekue, J M., et al. "A Double-blind Trial of a Fixed Combination of Mefloquine Plus Sulfadoxine-pyrimethamine Compared With Sulfadoxine-pyrimethamine Alone in Symptomatic Falciparum Malaria." Bulletin of the World Health Organization, vol. 65, no. 3, 1987, pp. 369-73.
Ekue JM, Phiri DE, Sheth UK, et al. A double-blind trial of a fixed combination of mefloquine plus sulfadoxine-pyrimethamine compared with sulfadoxine-pyrimethamine alone in symptomatic falciparum malaria. Bull World Health Organ. 1987;65(3):369-73.
Ekue, J. M., Phiri, D. E., Sheth, U. K., & Mukunyandela, M. (1987). A double-blind trial of a fixed combination of mefloquine plus sulfadoxine-pyrimethamine compared with sulfadoxine-pyrimethamine alone in symptomatic falciparum malaria. Bulletin of the World Health Organization, 65(3), 369-73.
Ekue JM, et al. A Double-blind Trial of a Fixed Combination of Mefloquine Plus Sulfadoxine-pyrimethamine Compared With Sulfadoxine-pyrimethamine Alone in Symptomatic Falciparum Malaria. Bull World Health Organ. 1987;65(3):369-73. PubMed PMID: 3311440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A double-blind trial of a fixed combination of mefloquine plus sulfadoxine-pyrimethamine compared with sulfadoxine-pyrimethamine alone in symptomatic falciparum malaria. AU - Ekue,J M, AU - Phiri,D E, AU - Sheth,U K, AU - Mukunyandela,M, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 369 EP - 73 JF - Bulletin of the World Health Organization JO - Bull World Health Organ VL - 65 IS - 3 N2 - A total of 100 male Zambian patients with symptomatic falciparum malaria were treated with either two tablets of mefloquine plus sulfadoxine-pyrimethamine (Fansimef) or three tablets of sulfadoxine-pyrimethamine (Fansidar) as a single dose. The patients were kept under observation from day 0 (day of treatment) to day 28 and all were cured. An S-type of response was seen in all patients; one patient in the Fansimef group inexplicably remained positive for Plasmodium falciparum trophozoites until day 6. There were no cases of recrudescence.The rate of clearance of parasitaemia was similar in both groups. The rate of clearance of fever was marginally faster in the Fansimef group. Side-effects such as pruritus, diarrhoea and abdominal pain occurred after both drugs but were mild and transient; tolerance was slightly better with Fansimef. Severe orthostatic hypotension occurred in 20% of the Fansidar patients and in only 2% of the Fansimef patients; this was reversed by bed rest. Haematological and biochemical parameters were generally not modified in an undesirable manner by the administration of these drugs. SN - 0042-9686 UR - https://www.unboundmedicine.com/medline/citation/3311440/A_double_blind_trial_of_a_fixed_combination_of_mefloquine_plus_sulfadoxine_pyrimethamine_compared_with_sulfadoxine_pyrimethamine_alone_in_symptomatic_falciparum_malaria_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/3311440/ DB - PRIME DP - Unbound Medicine ER -