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Co-infection of SARS-CoV-2 with other respiratory viruses and performance of lower respiratory tract samples for the diagnosis of COVID-19.
Int J Infect Dis. 2020 Oct 25; 102:10-13.IJ

Abstract

OBJECTIVES

This study was performed during the early outbreak period of coronavirus disease 2019 (COVID-19) and the seasonal epidemics of other respiratory viral infections, in order to describe the extent of co-infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with other respiratory viruses. It also compared the diagnostic performances of upper respiratory tract (URT) and lower respiratory tract (LRT) samples for SARS-CoV-2 infection.

METHODS

From 25 January to 29 March 2020, all URT and LRT samples collected from patients with suspected COVID-19 received in the virology laboratory of Pitié-Salpêtrière University Hospital (Paris, France) were simultaneously tested for SARS-CoV-2 and other respiratory viruses.

RESULTS

A total of 1423 consecutive patients were tested: 677 (47.6%) males, 746 (52.4%) females, median age 50 (range, 1-103) years. Twenty-one (1.5%) patients were positive for both SARS-CoV-2 and other respiratory viruses. The detection rate of SARS-CoV-2 was significantly higher in LRT than in URT (53.6% vs. 13.4%; p<0.0001). The analysis of paired samples from 117 (8.2%) patients showed that SARS-CoV-2 load was lower in URT than in LRT samples in 65% of cases.

CONCLUSION

The detection of other respiratory viruses in patients during this epidemic period could not rule out SARS-CoV-2 co-infection. Furthermore, LRT samples increased the accuracy of diagnosis of COVID-19.

Authors+Show Affiliations

AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Service de Virologie, Paris, France; Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), Paris, France.AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Service d'Accueil des Urgences, Paris, France; Sorbonne Universités GRC-14 BIOSFAST et INSERM UMR-S 1166, Paris, France.Sorbonne Université, INSERM, UMRS1158 Neurophysiologie respiratoire expérimentale et clinique, Paris, France; AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Service de Pneumologie, Médecine intensive-Réanimation (Département 'R3S'), Paris, France.Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), Paris, France; AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Service de Maladies Infectieuses et Tropicales, Paris, France.AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Service de Médecine Intensive Réanimation, Institut de Cardiologie, Paris, France; Sorbonne Université, INSERM, UMRS_1166-ICAN Institut de Cardiométabolisme et Nutrition, Paris, France.AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Service de Virologie, Paris, France; Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), Paris, France.AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Service de Virologie, Paris, France; Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), Paris, France.AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Service de Virologie, Paris, France; Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), Paris, France.AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Service de Virologie, Paris, France; Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), Paris, France.AP-HP, Sorbonne Université, Hôpital Pitié-Salpêtrière, Service de Virologie, Paris, France; Sorbonne Université, INSERM U1136, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP), Paris, France. Electronic address: david.boutolleau@aphp.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33115679

Citation

Burrel, Sonia, et al. "Co-infection of SARS-CoV-2 With Other Respiratory Viruses and Performance of Lower Respiratory Tract Samples for the Diagnosis of COVID-19." International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, vol. 102, 2020, pp. 10-13.
Burrel S, Hausfater P, Dres M, et al. Co-infection of SARS-CoV-2 with other respiratory viruses and performance of lower respiratory tract samples for the diagnosis of COVID-19. Int J Infect Dis. 2020;102:10-13.
Burrel, S., Hausfater, P., Dres, M., Pourcher, V., Luyt, C. E., Teyssou, E., Soulié, C., Calvez, V., Marcelin, A. G., & Boutolleau, D. (2020). Co-infection of SARS-CoV-2 with other respiratory viruses and performance of lower respiratory tract samples for the diagnosis of COVID-19. International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases, 102, 10-13. https://doi.org/10.1016/j.ijid.2020.10.040
Burrel S, et al. Co-infection of SARS-CoV-2 With Other Respiratory Viruses and Performance of Lower Respiratory Tract Samples for the Diagnosis of COVID-19. Int J Infect Dis. 2020 Oct 25;102:10-13. PubMed PMID: 33115679.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Co-infection of SARS-CoV-2 with other respiratory viruses and performance of lower respiratory tract samples for the diagnosis of COVID-19. AU - Burrel,Sonia, AU - Hausfater,Pierre, AU - Dres,Martin, AU - Pourcher,Valérie, AU - Luyt,Charles-Edouard, AU - Teyssou,Elisa, AU - Soulié,Cathia, AU - Calvez,Vincent, AU - Marcelin,Anne-Geneviève, AU - Boutolleau,David, Y1 - 2020/10/25/ PY - 2020/07/10/received PY - 2020/10/19/revised PY - 2020/10/22/accepted PY - 2020/10/30/pubmed PY - 2020/10/30/medline PY - 2020/10/29/entrez KW - Co-infection KW - Lower respiratory tract KW - Other respiratory viruses KW - SARS-CoV-2 SP - 10 EP - 13 JF - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JO - Int J Infect Dis VL - 102 N2 - OBJECTIVES: This study was performed during the early outbreak period of coronavirus disease 2019 (COVID-19) and the seasonal epidemics of other respiratory viral infections, in order to describe the extent of co-infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with other respiratory viruses. It also compared the diagnostic performances of upper respiratory tract (URT) and lower respiratory tract (LRT) samples for SARS-CoV-2 infection. METHODS: From 25 January to 29 March 2020, all URT and LRT samples collected from patients with suspected COVID-19 received in the virology laboratory of Pitié-Salpêtrière University Hospital (Paris, France) were simultaneously tested for SARS-CoV-2 and other respiratory viruses. RESULTS: A total of 1423 consecutive patients were tested: 677 (47.6%) males, 746 (52.4%) females, median age 50 (range, 1-103) years. Twenty-one (1.5%) patients were positive for both SARS-CoV-2 and other respiratory viruses. The detection rate of SARS-CoV-2 was significantly higher in LRT than in URT (53.6% vs. 13.4%; p<0.0001). The analysis of paired samples from 117 (8.2%) patients showed that SARS-CoV-2 load was lower in URT than in LRT samples in 65% of cases. CONCLUSION: The detection of other respiratory viruses in patients during this epidemic period could not rule out SARS-CoV-2 co-infection. Furthermore, LRT samples increased the accuracy of diagnosis of COVID-19. SN - 1878-3511 UR - https://www.unboundmedicine.com/medline/citation/33115679/Co-infection_of_SARS-CoV-2_with_other_respiratory_viruses_and_performance_of_lower_respiratory_tract_samples_for_the_diagnosis_of_COVID-19 L2 - https://linkinghub.elsevier.com/retrieve/pii/S1201-9712(20)32244-X DB - PRIME DP - Unbound Medicine ER -