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Study of Bacterial Pathogens in Urinary Tract Infection and their Antimicrobial Sensitivity Pattern in the Setting of Gynecology Outpatient Department.
Mymensingh Med J. 2020 Oct; 29(4):838-846.MM

Abstract

Urinary tract infection (UTI) is commonly encountered in both community and hospital settings and is often associated with significant morbidity. The inappropriate administration of antibiotics to treat UTI increases the development of antimicrobial resistance to antibiotics. This cross-sectional study was conducted at the gynecology outpatient department (OPD) of Mymensingh Medical College Hospital, Bangladesh, from January 2018 to November 2019 to determine the frequency of causative micro-organisms of UTIs and their antibiotic resistance pattern. Four hundred eight women presenting with the symptoms of UTI referred with a diagnosis of UTI based on a urine routine examination, culture, and sensitivity reports to the OPD were included in the study. Antibiotic sensitivity testing was done in the microbiology department of the hospital following the Kirby-Bauer disc diffusion method. E. coli was the most common (48.5%) organism isolated, followed by Proteus (21.6%), Klebsiella (15.0%), Enterococcus spp. (4.7%), S. aureus (3.9%), Acinetobacter spp. (3.9%), and Pseudomonas (2.5%). The distribution of the causative organisms in various age groups of the patients was similar. Overall, most (>80%) of the organisms were resistant to Erythromycin (93%), Ampicillin (92%), Amoxycillin (90%), and Cefuroxime (84%); the highest sensitivity was found for Meropenem (85%), Amikacin (81%), Gentamycin (79%), and Nitrofurantoin (71%). The highest sensitivity of E. coli was found for Meropenem (90%), Amikacin (83%), Gentamycin (83%), and Nitrofurantoin (76%). E. coli were resistant to Ampicillin (100%), Amoxycillin (100%), and Erythromycin (100%), Cephalexin (85%), and Cefuroxime (85%). Proteus was highly sensitive to Meropenem (90%) and Gentamycin (82%), whereas highly resistant to most of the antibiotics. Klebsiella was found sensitive to Amikacin (90%), Gentamycin (77%), Meropenem (74%), and Ciprofloxacin (74%) and resistant to Ampicillin (100%), Erythromycin (87%), Cefixime (80%), and Cefuroxime (76%). The results of this study showed that resistance is likely to be against the most commonly used antibiotics. Most of the uropathogens showed sensitivity to injectable antibiotics, namely Meropenem, Gentamycin, and Amikacin.

Authors+Show Affiliations

Dr Fatema Tuz Zahura Aalpona, Medical Officer, Gyne & Obs Outpatient Department, Mymensingh Medical College Hospital, Mymensingh, Bangladesh; E-mail: aalponasomc@gmail.com.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33116085

Citation

Aalpona, F Z., and A B. Kamrul-Hasan. "Study of Bacterial Pathogens in Urinary Tract Infection and Their Antimicrobial Sensitivity Pattern in the Setting of Gynecology Outpatient Department." Mymensingh Medical Journal : MMJ, vol. 29, no. 4, 2020, pp. 838-846.
Aalpona FZ, Kamrul-Hasan AB. Study of Bacterial Pathogens in Urinary Tract Infection and their Antimicrobial Sensitivity Pattern in the Setting of Gynecology Outpatient Department. Mymensingh Med J. 2020;29(4):838-846.
Aalpona, F. Z., & Kamrul-Hasan, A. B. (2020). Study of Bacterial Pathogens in Urinary Tract Infection and their Antimicrobial Sensitivity Pattern in the Setting of Gynecology Outpatient Department. Mymensingh Medical Journal : MMJ, 29(4), 838-846.
Aalpona FZ, Kamrul-Hasan AB. Study of Bacterial Pathogens in Urinary Tract Infection and Their Antimicrobial Sensitivity Pattern in the Setting of Gynecology Outpatient Department. Mymensingh Med J. 2020;29(4):838-846. PubMed PMID: 33116085.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Study of Bacterial Pathogens in Urinary Tract Infection and their Antimicrobial Sensitivity Pattern in the Setting of Gynecology Outpatient Department. AU - Aalpona,F Z, AU - Kamrul-Hasan,A B, PY - 2020/10/29/entrez PY - 2020/10/30/pubmed PY - 2020/10/31/medline SP - 838 EP - 846 JF - Mymensingh medical journal : MMJ JO - Mymensingh Med J VL - 29 IS - 4 N2 - Urinary tract infection (UTI) is commonly encountered in both community and hospital settings and is often associated with significant morbidity. The inappropriate administration of antibiotics to treat UTI increases the development of antimicrobial resistance to antibiotics. This cross-sectional study was conducted at the gynecology outpatient department (OPD) of Mymensingh Medical College Hospital, Bangladesh, from January 2018 to November 2019 to determine the frequency of causative micro-organisms of UTIs and their antibiotic resistance pattern. Four hundred eight women presenting with the symptoms of UTI referred with a diagnosis of UTI based on a urine routine examination, culture, and sensitivity reports to the OPD were included in the study. Antibiotic sensitivity testing was done in the microbiology department of the hospital following the Kirby-Bauer disc diffusion method. E. coli was the most common (48.5%) organism isolated, followed by Proteus (21.6%), Klebsiella (15.0%), Enterococcus spp. (4.7%), S. aureus (3.9%), Acinetobacter spp. (3.9%), and Pseudomonas (2.5%). The distribution of the causative organisms in various age groups of the patients was similar. Overall, most (>80%) of the organisms were resistant to Erythromycin (93%), Ampicillin (92%), Amoxycillin (90%), and Cefuroxime (84%); the highest sensitivity was found for Meropenem (85%), Amikacin (81%), Gentamycin (79%), and Nitrofurantoin (71%). The highest sensitivity of E. coli was found for Meropenem (90%), Amikacin (83%), Gentamycin (83%), and Nitrofurantoin (76%). E. coli were resistant to Ampicillin (100%), Amoxycillin (100%), and Erythromycin (100%), Cephalexin (85%), and Cefuroxime (85%). Proteus was highly sensitive to Meropenem (90%) and Gentamycin (82%), whereas highly resistant to most of the antibiotics. Klebsiella was found sensitive to Amikacin (90%), Gentamycin (77%), Meropenem (74%), and Ciprofloxacin (74%) and resistant to Ampicillin (100%), Erythromycin (87%), Cefixime (80%), and Cefuroxime (76%). The results of this study showed that resistance is likely to be against the most commonly used antibiotics. Most of the uropathogens showed sensitivity to injectable antibiotics, namely Meropenem, Gentamycin, and Amikacin. SN - 2408-8757 UR - https://www.unboundmedicine.com/medline/citation/33116085/Study_of_Bacterial_Pathogens_in_Urinary_Tract_Infection_and_their_Antimicrobial_Sensitivity_Pattern_in_the_Setting_of_Gynecology_Outpatient_Department_ DB - PRIME DP - Unbound Medicine ER -