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Anterior Acute Uveitis Report in a SARS-CoV-2 Patient Managed with Adjunctive Topical Antiseptic Prophylaxis Preventing 2019-nCoV Spread Through the Ocular Surface Route.
Int Med Case Rep J. 2020; 13:513-520.IM

Abstract

Purpose

To report the clinical-epidemiological association between acute anterior uveitis and acute bilateral follicular conjunctivitis in a 30-year-old female patient who had tested positive for the SARS-CoV-2 RT-PCR.

Methods

A 30-year-old female visited emergency ophthalmology care at the Siena Crosslinking Centre, Italy, for a bilateral eye redness lasting two weeks, associated with unilateral photophobia and blurred vision in her right eye. She visited on the 23rd of March 2020 in the full pandemic period and presented chills and fever with a temperature of 39.0°C, associated with complete loss of taste. Since eye examination findings, systemic symptoms and epidemiological criteria correlated with SARS-CoV-2 infection, she was referred to Siena University Hospital, Italy, for the SARS-CoV-2 nasopharyngeal buffer and haematological examinations for uveitis.

Results

Eye examination revealed bilateral conjunctival hyperaemia with acute follicular conjunctivitis associated with right eye acute anterior uveitis characterized by diffuse pigmentary and whitish immune precipitates over the anterior capsule of the crystalline lens and initial anterior lens opacity explaining the blurred vision. Adjunctive prophylactic eye topical treatment, included in the acronym SHYPIO (0.02% sodium hypochlorite solution, 0.6% povidone iodine eye-drops and 10.50% ozonized oil eye-drops), was associated with conventional uveitis therapy to prevent the virus spread through the ocular surface route.

Conclusion

Our report demonstrates that complicated acute anterior uveitis (iridocyclitis) with blurred vision could be associated with SARS-CoV-2 infection, being potentially sight-threatening for early complicated lens opacity. Ophthalmologists examining suspected or asymptomatic patients should be aware of the risk of 2019-nCoV infection.

Authors+Show Affiliations

Department of Medicine, Surgery and Neurosciences, Post-Graduate Ophthalmology School, University of Siena, Siena, Italy. Departmental Ophthalmology Unit, Alta Val d' Elsa Hospital, Siena, Italy. Ophthalmology Operative Unit, Casentino Hospital, Arezzo, Italy. Siena Crosslinking Center, Siena, Italy.Ophthalmology Unit, Vito Fazzi Hospital, Lecce, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33116943

Citation

Mazzotta, Cosimo, and Ermete Giancipoli. "Anterior Acute Uveitis Report in a SARS-CoV-2 Patient Managed With Adjunctive Topical Antiseptic Prophylaxis Preventing 2019-nCoV Spread Through the Ocular Surface Route." International Medical Case Reports Journal, vol. 13, 2020, pp. 513-520.
Mazzotta C, Giancipoli E. Anterior Acute Uveitis Report in a SARS-CoV-2 Patient Managed with Adjunctive Topical Antiseptic Prophylaxis Preventing 2019-nCoV Spread Through the Ocular Surface Route. Int Med Case Rep J. 2020;13:513-520.
Mazzotta, C., & Giancipoli, E. (2020). Anterior Acute Uveitis Report in a SARS-CoV-2 Patient Managed with Adjunctive Topical Antiseptic Prophylaxis Preventing 2019-nCoV Spread Through the Ocular Surface Route. International Medical Case Reports Journal, 13, 513-520. https://doi.org/10.2147/IMCRJ.S260252
Mazzotta C, Giancipoli E. Anterior Acute Uveitis Report in a SARS-CoV-2 Patient Managed With Adjunctive Topical Antiseptic Prophylaxis Preventing 2019-nCoV Spread Through the Ocular Surface Route. Int Med Case Rep J. 2020;13:513-520. PubMed PMID: 33116943.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anterior Acute Uveitis Report in a SARS-CoV-2 Patient Managed with Adjunctive Topical Antiseptic Prophylaxis Preventing 2019-nCoV Spread Through the Ocular Surface Route. AU - Mazzotta,Cosimo, AU - Giancipoli,Ermete, Y1 - 2020/10/13/ PY - 2020/04/28/received PY - 2020/07/31/accepted PY - 2020/10/29/entrez PY - 2020/10/30/pubmed PY - 2020/10/30/medline KW - COVID-19 conjunctivitis KW - COVID-19 uveitis KW - SARS-CoV-2 anterior uveitis KW - SARS-CoV-2 associated uveitis KW - SARS-CoV-2 conjunctivitis KW - SARS-CoV-2 uveitis SP - 513 EP - 520 JF - International medical case reports journal JO - Int Med Case Rep J VL - 13 N2 - Purpose: To report the clinical-epidemiological association between acute anterior uveitis and acute bilateral follicular conjunctivitis in a 30-year-old female patient who had tested positive for the SARS-CoV-2 RT-PCR. Methods: A 30-year-old female visited emergency ophthalmology care at the Siena Crosslinking Centre, Italy, for a bilateral eye redness lasting two weeks, associated with unilateral photophobia and blurred vision in her right eye. She visited on the 23rd of March 2020 in the full pandemic period and presented chills and fever with a temperature of 39.0°C, associated with complete loss of taste. Since eye examination findings, systemic symptoms and epidemiological criteria correlated with SARS-CoV-2 infection, she was referred to Siena University Hospital, Italy, for the SARS-CoV-2 nasopharyngeal buffer and haematological examinations for uveitis. Results: Eye examination revealed bilateral conjunctival hyperaemia with acute follicular conjunctivitis associated with right eye acute anterior uveitis characterized by diffuse pigmentary and whitish immune precipitates over the anterior capsule of the crystalline lens and initial anterior lens opacity explaining the blurred vision. Adjunctive prophylactic eye topical treatment, included in the acronym SHYPIO (0.02% sodium hypochlorite solution, 0.6% povidone iodine eye-drops and 10.50% ozonized oil eye-drops), was associated with conventional uveitis therapy to prevent the virus spread through the ocular surface route. Conclusion: Our report demonstrates that complicated acute anterior uveitis (iridocyclitis) with blurred vision could be associated with SARS-CoV-2 infection, being potentially sight-threatening for early complicated lens opacity. Ophthalmologists examining suspected or asymptomatic patients should be aware of the risk of 2019-nCoV infection. SN - 1179-142X UR - https://www.unboundmedicine.com/medline/citation/33116943/Anterior_Acute_Uveitis_Report_in_a_SARS_CoV_2_Patient_Managed_with_Adjunctive_Topical_Antiseptic_Prophylaxis_Preventing_2019_nCoV_Spread_Through_the_Ocular_Surface_Route_ L2 - https://dx.doi.org/10.2147/IMCRJ.S260252 DB - PRIME DP - Unbound Medicine ER -
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