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Association of digestive symptoms with severity and mortality of COVID-19: A protocol for systematic review and meta-analysis.
Medicine (Baltimore). 2020 Oct 23; 99(43):e22736.M

Abstract

BACKGROUND

Gastrointestinal manifestations are common in patients with COVID-19, but the association between specific digestive symptoms and COVID-19 prognosis remains unclear. This study aims to assess whether digestive symptoms are associated with COVID-19 severity and mortality.

METHODS

We will search PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials up to September, 2020, to identify studies that compared the prevalence of at least one specific digestive symptom between severe and non-severe COVID-19 patients or between non-survivors and survivors. Two independent reviewers will assess the risk of bias of the included cohort studies using the modified Newcastle-Ottawa Scale. Meta-analyses will be conducted to estimate the pooled prevalence of individual symptoms using the inverse variance method with the random-effects model. We will conduct subgroup analyses, sensitivity analyses, and meta-regression analyses to explore the sources of heterogeneity. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach will be used to assess the quality of the evidence.

RESULTS

The results of this study will be published in a peer-reviewed journal.

CONCLUSION

Our meta-analysis will comprehensively evaluate the association between different digestive symptoms and the severity and mortality of patients infected with COVID-19. This study will provide evidence to help determine whether special protective measures and treatment options are needed for patients with digestive system comorbidities during the COVID-19 pandemic.

INPLASY REGISTRATION NUMBER

INPLASY202090055.

Authors+Show Affiliations

Department of Nursing.Department of Nursing.The Second Ward of Orthopedics Department.The First Ward of Urology Department.The First Ward of Cardiovascular Medicine Department, Lanzhou University Second Hospital, Lanzhou, China.Department of Nursing.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

33120773

Citation

Zhang, Yufang, et al. "Association of Digestive Symptoms With Severity and Mortality of COVID-19: a Protocol for Systematic Review and Meta-analysis." Medicine, vol. 99, no. 43, 2020, pp. e22736.
Zhang Y, Ma P, Zhang X, et al. Association of digestive symptoms with severity and mortality of COVID-19: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2020;99(43):e22736.
Zhang, Y., Ma, P., Zhang, X., Pei, Z., Wang, H., & Dou, X. (2020). Association of digestive symptoms with severity and mortality of COVID-19: A protocol for systematic review and meta-analysis. Medicine, 99(43), e22736. https://doi.org/10.1097/MD.0000000000022736
Zhang Y, et al. Association of Digestive Symptoms With Severity and Mortality of COVID-19: a Protocol for Systematic Review and Meta-analysis. Medicine (Baltimore). 2020 Oct 23;99(43):e22736. PubMed PMID: 33120773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of digestive symptoms with severity and mortality of COVID-19: A protocol for systematic review and meta-analysis. AU - Zhang,Yufang, AU - Ma,Peifen, AU - Zhang,Xiu, AU - Pei,Zhuoxi, AU - Wang,Haixia, AU - Dou,Xinman, PY - 2020/10/30/entrez PY - 2020/10/31/pubmed PY - 2020/11/11/medline SP - e22736 EP - e22736 JF - Medicine JO - Medicine (Baltimore) VL - 99 IS - 43 N2 - BACKGROUND: Gastrointestinal manifestations are common in patients with COVID-19, but the association between specific digestive symptoms and COVID-19 prognosis remains unclear. This study aims to assess whether digestive symptoms are associated with COVID-19 severity and mortality. METHODS: We will search PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials up to September, 2020, to identify studies that compared the prevalence of at least one specific digestive symptom between severe and non-severe COVID-19 patients or between non-survivors and survivors. Two independent reviewers will assess the risk of bias of the included cohort studies using the modified Newcastle-Ottawa Scale. Meta-analyses will be conducted to estimate the pooled prevalence of individual symptoms using the inverse variance method with the random-effects model. We will conduct subgroup analyses, sensitivity analyses, and meta-regression analyses to explore the sources of heterogeneity. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach will be used to assess the quality of the evidence. RESULTS: The results of this study will be published in a peer-reviewed journal. CONCLUSION: Our meta-analysis will comprehensively evaluate the association between different digestive symptoms and the severity and mortality of patients infected with COVID-19. This study will provide evidence to help determine whether special protective measures and treatment options are needed for patients with digestive system comorbidities during the COVID-19 pandemic. INPLASY REGISTRATION NUMBER: INPLASY202090055. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/33120773/Association_of_digestive_symptoms_with_severity_and_mortality_of_COVID_19:_A_protocol_for_systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1097/MD.0000000000022736 DB - PRIME DP - Unbound Medicine ER -