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Impact of cancer on mortality and severity of corona virus disease 2019: A protocol for systematic review and meta-analysis.
Medicine (Baltimore). 2020 Oct 30; 99(44):e23005.M

Abstract

BACKGROUND

Cancer patients are in a state of systemic immunosuppression and are considered a highly vulnerable population in the Corona Virus Disease 2019 (COVID-19) epidemic. However, the relationship between cancer and the severity and mortality of patients with COVID-19 remains unclear. This study aims to evaluate whether cancer patients with COVID-19 may be at an increased risk of severe illness and mortality.

METHODS

We will perform comprehensive searches in PubMed, EMBASE.com, Web of Science, and the Cochrane Central Register of Controlled Trials to identify studies providing prevalence of cancer between patients with severe and non-severe illness or between non-survivors and survivors. We will use the Newcastle-Ottawa quality assessment scale to assess the quality of included studies. We will conduct pairwise meta-analyses to compute the odds ratio and 95% confidence interval using the Mantel Haenszel method with the random-effects model. The statistical heterogeneity will be assessed using the I statistic. Subgroup analyses, sensitivity analyses, and meta-regression analyses will be performed to explore the sources of heterogeneity.

RESULTS

The results of this study will be published in a peer-reviewed journal.

CONCLUSION

Our meta-analysis will systematically evaluate the association between cancer and the severity and mortality of patients with COVID-19. This study will provide evidence to help determine whether cancer patients should be provided with special precautions and advised to use stronger personal protection.

INPLASY REGISTRATION NUMBER

INPLASY202090093.

Authors+Show Affiliations

Department of Geriatric Respiratory Medicine, Lanzhou University First Hospital.Department of Critical Care Medicine, The Second Provincial People's Hospital of Gansu.Department of Endocrinology, Lanzhou University First Hospital.Department of Geriatric Respiratory Medicine, Lanzhou University First Hospital.Department of Geriatric Respiratory Medicine, Lanzhou University First Hospital.School of Basic Medical Sciences, Lanzhou University.School of Basic Medical Sciences, Lanzhou University.The First Clinical Medical College of Lanzhou University, Lanzhou, China.The First Clinical Medical College of Lanzhou University, Lanzhou, China.The First Clinical Medical College of Lanzhou University, Lanzhou, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33126383

Citation

Zhang, Yi, et al. "Impact of Cancer On Mortality and Severity of Corona Virus Disease 2019: a Protocol for Systematic Review and Meta-analysis." Medicine, vol. 99, no. 44, 2020, pp. e23005.
Zhang Y, Han H, Tian Y, et al. Impact of cancer on mortality and severity of corona virus disease 2019: A protocol for systematic review and meta-analysis. Medicine (Baltimore). 2020;99(44):e23005.
Zhang, Y., Han, H., Tian, Y., Dong, J., Yu, Y., Kang, Y., Xing, L., Lian, R., Zhang, R., & Xie, D. (2020). Impact of cancer on mortality and severity of corona virus disease 2019: A protocol for systematic review and meta-analysis. Medicine, 99(44), e23005. https://doi.org/10.1097/MD.0000000000023005
Zhang Y, et al. Impact of Cancer On Mortality and Severity of Corona Virus Disease 2019: a Protocol for Systematic Review and Meta-analysis. Medicine (Baltimore). 2020 Oct 30;99(44):e23005. PubMed PMID: 33126383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of cancer on mortality and severity of corona virus disease 2019: A protocol for systematic review and meta-analysis. AU - Zhang,Yi, AU - Han,Hao, AU - Tian,Yunling, AU - Dong,Jing, AU - Yu,Yage, AU - Kang,Yingying, AU - Xing,Lina, AU - Lian,Rongna, AU - Zhang,Ruinian, AU - Xie,Dairong, PY - 2020/10/31/entrez PY - 2020/11/1/pubmed PY - 2020/11/11/medline SP - e23005 EP - e23005 JF - Medicine JO - Medicine (Baltimore) VL - 99 IS - 44 N2 - BACKGROUND: Cancer patients are in a state of systemic immunosuppression and are considered a highly vulnerable population in the Corona Virus Disease 2019 (COVID-19) epidemic. However, the relationship between cancer and the severity and mortality of patients with COVID-19 remains unclear. This study aims to evaluate whether cancer patients with COVID-19 may be at an increased risk of severe illness and mortality. METHODS: We will perform comprehensive searches in PubMed, EMBASE.com, Web of Science, and the Cochrane Central Register of Controlled Trials to identify studies providing prevalence of cancer between patients with severe and non-severe illness or between non-survivors and survivors. We will use the Newcastle-Ottawa quality assessment scale to assess the quality of included studies. We will conduct pairwise meta-analyses to compute the odds ratio and 95% confidence interval using the Mantel Haenszel method with the random-effects model. The statistical heterogeneity will be assessed using the I statistic. Subgroup analyses, sensitivity analyses, and meta-regression analyses will be performed to explore the sources of heterogeneity. RESULTS: The results of this study will be published in a peer-reviewed journal. CONCLUSION: Our meta-analysis will systematically evaluate the association between cancer and the severity and mortality of patients with COVID-19. This study will provide evidence to help determine whether cancer patients should be provided with special precautions and advised to use stronger personal protection. INPLASY REGISTRATION NUMBER: INPLASY202090093. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/33126383/Impact_of_cancer_on_mortality_and_severity_of_corona_virus_disease_2019:_A_protocol_for_systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1097/MD.0000000000023005 DB - PRIME DP - Unbound Medicine ER -