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The effect of mefloquine-sulfadoxine-pyrimethamine vs quinine on patients with complicated falciparum malaria.
Southeast Asian J Trop Med Public Health. 1987 Jun; 18(2):223-5.SA

Abstract

Sixty-six patients with complicated falciparum malaria (defined as anaemia, hyperpyrexia, jaundice, or more than 2% of RBC parasitised) were studied. Patients with cerebral signs and symptoms were not included in the study. Patients were randomised in pairs to receive either mefloquine 750 mg, sulfadoxine 1500 mg and pyrimethamine 75 mg (MSP) single oral dose or quinine (10 mg/kg tds X 7 days oral therapy). All the patients were admitted in hospital for 7 days and were followed on days 14, 21 and 28. All patients survived. The parasite clearance times in MSP treated patients were significantly shorter then those treated with quinine. There was no difference in fever clearance time in the two groups of patients. One patient was resistant to MSP at RII level and 5 patients were resistant at RI level. Among patients treated with quinine 3 patients were resistant at RI level.

Authors+Show Affiliations

Myint PT
Department of Medical Research, Ministry of Health, Rangoon, Burma.
Shwe T
No affiliation info available

MeSH

AdultAnimalsAntimalarialsDrug CombinationsFemaleHumansMalariaMaleMefloquinePlasmodium falciparumProspective StudiesPyrimethamineQuinineQuinolinesSulfadoxineSulfanilamides

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3313739

Citation

Myint, P T., and T Shwe. "The Effect of Mefloquine-sulfadoxine-pyrimethamine Vs Quinine On Patients With Complicated Falciparum Malaria." The Southeast Asian Journal of Tropical Medicine and Public Health, vol. 18, no. 2, 1987, pp. 223-5.
Myint PT, Shwe T. The effect of mefloquine-sulfadoxine-pyrimethamine vs quinine on patients with complicated falciparum malaria. Southeast Asian J Trop Med Public Health. 1987;18(2):223-5.
Myint, P. T., & Shwe, T. (1987). The effect of mefloquine-sulfadoxine-pyrimethamine vs quinine on patients with complicated falciparum malaria. The Southeast Asian Journal of Tropical Medicine and Public Health, 18(2), 223-5.
Myint PT, Shwe T. The Effect of Mefloquine-sulfadoxine-pyrimethamine Vs Quinine On Patients With Complicated Falciparum Malaria. Southeast Asian J Trop Med Public Health. 1987;18(2):223-5. PubMed PMID: 3313739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of mefloquine-sulfadoxine-pyrimethamine vs quinine on patients with complicated falciparum malaria. AU - Myint,P T, AU - Shwe,T, PY - 1987/6/1/pubmed PY - 1987/6/1/medline PY - 1987/6/1/entrez SP - 223 EP - 5 JF - The Southeast Asian journal of tropical medicine and public health JO - Southeast Asian J Trop Med Public Health VL - 18 IS - 2 N2 - Sixty-six patients with complicated falciparum malaria (defined as anaemia, hyperpyrexia, jaundice, or more than 2% of RBC parasitised) were studied. Patients with cerebral signs and symptoms were not included in the study. Patients were randomised in pairs to receive either mefloquine 750 mg, sulfadoxine 1500 mg and pyrimethamine 75 mg (MSP) single oral dose or quinine (10 mg/kg tds X 7 days oral therapy). All the patients were admitted in hospital for 7 days and were followed on days 14, 21 and 28. All patients survived. The parasite clearance times in MSP treated patients were significantly shorter then those treated with quinine. There was no difference in fever clearance time in the two groups of patients. One patient was resistant to MSP at RII level and 5 patients were resistant at RI level. Among patients treated with quinine 3 patients were resistant at RI level. SN - 0125-1562 UR - https://www.unboundmedicine.com/medline/citation/3313739/The_effect_of_mefloquine_sulfadoxine_pyrimethamine_vs_quinine_on_patients_with_complicated_falciparum_malaria_ DB - PRIME DP - Unbound Medicine ER -