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The Inflammasome in Times of COVID-19.
Front Immunol. 2020; 11:583373.FI

Abstract

Coronaviruses (CoVs) are members of the genus Betacoronavirus and the Coronaviridiae family responsible for infections such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and more recently, coronavirus disease-2019 (COVID-19). CoV infections present mainly as respiratory infections that lead to acute respiratory distress syndrome (ARDS). However, CoVs, such as COVID-19, also present as a hyperactivation of the inflammatory response that results in increased production of inflammatory cytokines such as interleukin (IL)-1β and its downstream molecule IL-6. The inflammasome is a multiprotein complex involved in the activation of caspase-1 that leads to the activation of IL-1β in a variety of diseases and infections such as CoV infection and in different tissues such as lungs, brain, intestines and kidneys, all of which have been shown to be affected in COVID-19 patients. Here we review the literature regarding the mechanism of inflammasome activation by CoV infection, the role of the inflammasome in ARDS, ventilator-induced lung injury (VILI), and Disseminated Intravascular Coagulation (DIC) as well as the potential mechanism by which the inflammasome may contribute to the damaging effects of inflammation in the cardiac, renal, digestive, and nervous systems in COVID-19 patients.

Authors+Show Affiliations

DRV Ventures, LLC, Miami, FL, United States.Department of Neurological Surgery and The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United States.Department of Neurological Surgery and The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United States. Department of Physiology and Biophysics, University of Miami Miller School of Medicine, Miami, FL, United States.Department of Neurological Surgery and The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, FL, United States. Center for Cognitive Neuroscience and Aging University of Miami Miller School of Medicine, Miami, FL, United States.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

33149733

Citation

de Rivero Vaccari, Juan Carlos, et al. "The Inflammasome in Times of COVID-19." Frontiers in Immunology, vol. 11, 2020, p. 583373.
de Rivero Vaccari JC, Dietrich WD, Keane RW, et al. The Inflammasome in Times of COVID-19. Front Immunol. 2020;11:583373.
de Rivero Vaccari, J. C., Dietrich, W. D., Keane, R. W., & de Rivero Vaccari, J. P. (2020). The Inflammasome in Times of COVID-19. Frontiers in Immunology, 11, 583373. https://doi.org/10.3389/fimmu.2020.583373
de Rivero Vaccari JC, et al. The Inflammasome in Times of COVID-19. Front Immunol. 2020;11:583373. PubMed PMID: 33149733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Inflammasome in Times of COVID-19. AU - de Rivero Vaccari,Juan Carlos, AU - Dietrich,W Dalton, AU - Keane,Robert W, AU - de Rivero Vaccari,Juan Pablo, Y1 - 2020/10/08/ PY - 2020/07/14/received PY - 2020/09/07/accepted PY - 2020/11/5/entrez PY - 2020/11/6/pubmed PY - 2020/11/18/medline KW - COVID-19 KW - IL-1beta KW - caspase-1 KW - coronavirus KW - inflammasome KW - inflammation SP - 583373 EP - 583373 JF - Frontiers in immunology JO - Front Immunol VL - 11 N2 - Coronaviruses (CoVs) are members of the genus Betacoronavirus and the Coronaviridiae family responsible for infections such as severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and more recently, coronavirus disease-2019 (COVID-19). CoV infections present mainly as respiratory infections that lead to acute respiratory distress syndrome (ARDS). However, CoVs, such as COVID-19, also present as a hyperactivation of the inflammatory response that results in increased production of inflammatory cytokines such as interleukin (IL)-1β and its downstream molecule IL-6. The inflammasome is a multiprotein complex involved in the activation of caspase-1 that leads to the activation of IL-1β in a variety of diseases and infections such as CoV infection and in different tissues such as lungs, brain, intestines and kidneys, all of which have been shown to be affected in COVID-19 patients. Here we review the literature regarding the mechanism of inflammasome activation by CoV infection, the role of the inflammasome in ARDS, ventilator-induced lung injury (VILI), and Disseminated Intravascular Coagulation (DIC) as well as the potential mechanism by which the inflammasome may contribute to the damaging effects of inflammation in the cardiac, renal, digestive, and nervous systems in COVID-19 patients. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/33149733/The_Inflammasome_in_Times_of_COVID_19_ L2 - https://doi.org/10.3389/fimmu.2020.583373 DB - PRIME DP - Unbound Medicine ER -