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Test utilization for the diagnosis of vitamin B12 and folate deficiency in local clinics in Korea.
J Clin Lab Anal. 2020 Nov; 34(11):e23441.JC

Abstract

BACKGROUND

Current guidelines pertaining to diagnosing macrocytic anemia in association with vitamin B12 and folate deficiency recommend that vitamin B12, folate, homocysteine, and methylmalonic acid assays should be assessed concurrently due to their close relationship in metabolism. We aimed to investigate the completion of these assays in local clinics and hospitals without in-house clinical laboratories in Korea.

METHODS

We retrospectively reviewed data from the laboratory information system between September 25, 2017, and June 30, 2019, to investigate usage rates of vitamin B12, folate, homocysteine, and methylmalonic acid assays in patients with macrocytic anemia.

RESULTS

During the study period, 14 894 Korean adults among 109 524 (13.6%) total hemoglobin-tested subjects underwent concurrent erythrocyte mean corpuscular volume (MCV) tests. Among these 14,894 adults, 265 (1.2%) from 94 local clinics or hospitals without in-house clinical laboratories in Korea had macrocytic anemia. Furthermore, among these 265 adults, only one woman underwent serum vitamin B12 and folate assay and one man underwent serum homocysteine testing during the study period. No patients among the 265 individuals with macrocytic anemia received erythrocyte folate or methylmalonic acid testing (with either serum, plasma, random urine, or 24-hour collected urine).

CONCLUSIONS

The results of this study provide basic information regarding utilization rates of assays in association with vitamin B12 and folate deficiency. Making more data available is expected to improve rates of testing in patients with macrocytic anemia in local clinics and hospitals without in-house clinical laboratories in Korea.

Authors+Show Affiliations

Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Korea. Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Korea.Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Korea.Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Korea.Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Korea.Department of Laboratory Medicine, Green Cross Laboratories, Yongin, Korea.Green Cross Laboratories, Yongin, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33156552

Citation

Choi, Rihwa, et al. "Test Utilization for the Diagnosis of Vitamin B12 and Folate Deficiency in Local Clinics in Korea." Journal of Clinical Laboratory Analysis, vol. 34, no. 11, 2020, pp. e23441.
Choi R, Oh Y, Park MJ, et al. Test utilization for the diagnosis of vitamin B12 and folate deficiency in local clinics in Korea. J Clin Lab Anal. 2020;34(11):e23441.
Choi, R., Oh, Y., Park, M. J., Kim, S., Kim, Y., Lee, S. G., & Lee, E. H. (2020). Test utilization for the diagnosis of vitamin B12 and folate deficiency in local clinics in Korea. Journal of Clinical Laboratory Analysis, 34(11), e23441. https://doi.org/10.1002/jcla.23441
Choi R, et al. Test Utilization for the Diagnosis of Vitamin B12 and Folate Deficiency in Local Clinics in Korea. J Clin Lab Anal. 2020;34(11):e23441. PubMed PMID: 33156552.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Test utilization for the diagnosis of vitamin B12 and folate deficiency in local clinics in Korea. AU - Choi,Rihwa, AU - Oh,Youngju, AU - Park,Mi-Jung, AU - Kim,Serim, AU - Kim,Youngrae, AU - Lee,Sang Gon, AU - Lee,Eun Hee, Y1 - 2020/11/06/ PY - 2020/04/08/received PY - 2020/06/01/revised PY - 2020/06/03/accepted PY - 2020/11/7/pubmed PY - 2021/9/8/medline PY - 2020/11/6/entrez KW - folate KW - homocysteine KW - methylmalonic acid KW - test utilization KW - vitamin B12 SP - e23441 EP - e23441 JF - Journal of clinical laboratory analysis JO - J Clin Lab Anal VL - 34 IS - 11 N2 - BACKGROUND: Current guidelines pertaining to diagnosing macrocytic anemia in association with vitamin B12 and folate deficiency recommend that vitamin B12, folate, homocysteine, and methylmalonic acid assays should be assessed concurrently due to their close relationship in metabolism. We aimed to investigate the completion of these assays in local clinics and hospitals without in-house clinical laboratories in Korea. METHODS: We retrospectively reviewed data from the laboratory information system between September 25, 2017, and June 30, 2019, to investigate usage rates of vitamin B12, folate, homocysteine, and methylmalonic acid assays in patients with macrocytic anemia. RESULTS: During the study period, 14 894 Korean adults among 109 524 (13.6%) total hemoglobin-tested subjects underwent concurrent erythrocyte mean corpuscular volume (MCV) tests. Among these 14,894 adults, 265 (1.2%) from 94 local clinics or hospitals without in-house clinical laboratories in Korea had macrocytic anemia. Furthermore, among these 265 adults, only one woman underwent serum vitamin B12 and folate assay and one man underwent serum homocysteine testing during the study period. No patients among the 265 individuals with macrocytic anemia received erythrocyte folate or methylmalonic acid testing (with either serum, plasma, random urine, or 24-hour collected urine). CONCLUSIONS: The results of this study provide basic information regarding utilization rates of assays in association with vitamin B12 and folate deficiency. Making more data available is expected to improve rates of testing in patients with macrocytic anemia in local clinics and hospitals without in-house clinical laboratories in Korea. SN - 1098-2825 UR - https://www.unboundmedicine.com/medline/citation/33156552/Test_utilization_for_the_diagnosis_of_vitamin_B12_and_folate_deficiency_in_local_clinics_in_Korea_ L2 - https://doi.org/10.1002/jcla.23441 DB - PRIME DP - Unbound Medicine ER -