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[Study on drug properties and syndrome-symptom-formula-herb network of traditional Chinese medicine in treatment of effort angina pectoris based on data visualization].
Zhongguo Zhong Yao Za Zhi. 2020 Sep; 45(18):4482-4489.ZZ

Abstract

This article aims to explore drug properties and syndrome-symptom-formula-herb network of traditional Chinese medicine(TCM) in the treatment of effort angina pectoris based on data visualization, and provide useful references for clinical diagnosis and treatment. Literatures about TCM formula for effort angina pectoris from databases of CNKI, WanFang, VIP, and CBM were retrieved from the database-building to August 31, 2019. The name of syndromes, symptoms, formulas, and herbs were standardized, and the corresponding databases were established. Frequency, four properties, five flavors, and meridian were analyzed. Visualized syndrome-symptom-formula-herb network relationships were constructed by bioinformatic analysis. A total of 202 formulas were included, and 218 kinds of TCM were involved. There were 56 herbs with the use frequency of more than 10, involving 78 syndromes and 162 symptoms. TCM formulas in the treatment of effort angina pectoris mainly included herbs with effects in invigorating blood circulation and eliminating stasis, tonifying deficiency, Qi-regulating, resolving phlegm and relieving cough and asthma, relieving exterior disorder, and heat-clearing. The main properties were warm, cold and mild(accounting for 95%); the main flavors were sweet, bitter and pungent(accounting for 89%); and meridians were mainly spleen, heart, liver, lung, stomach, and kidney(accounting for 89%). Syndrome-symptom-formula-herb network of TCM in the treatment of effort angina pectoris were successfully constructed. The high-frequency syndromes of this disease were Qi deficiency and blood stasis, Qi stagnation and blood stasis, heart blood stasis, and turbid phlegm and blood stasis, and its high-frequency symptoms were chest tightness, chest pain, palpitation, shortness of breath, fatigue, dark purple tongue, spontaneous sweating, and abundant phlegm. High-frequency core formulas of this disease included Xuefu Zhuyu Decoction, Gualou Xiebai Banxia Decoction, Danshen Decoction, Taohong Siwu Decoction, Shengmai Powder, Buyang Huanwu Decoction and Zhigancao Decoction, and their core herbs included Salviae Miltiorrhizae Radix et Rhizoma, Astragali Radix, Chuanxiong Rhizoma, Ginseng Radix et Rhizoma, Trichosanthis Fructus, Allium Macrostemonis Bulbus, Notoginseng Radix et Rhizoma, Persicae Semen, Carthami Flos, Atractylodis Macrocephalae Rhizoma, Angelicae Sinensis Radix, Paeoniae Radix Rubra, Poria, Pinelliae Rhizoma Praeparatum. Drug properties and syndrome-symptom-formula-herb networks of TCM in the treatment of effort angina pectoris can realize data visualization, objectively reflect the clinical syndrome differentiation and rule of medication, and provide reference for clinical diagnosis and treatment.

Authors+Show Affiliations

Department of Pharmacy, Gansu Provincial People's Hospital Lanzhou 730000, China Department of Pharmacy, Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China.Department of Pharmacy, Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China.Department of Pharmacy, Gansu Provincial People's Hospital Lanzhou 730000, China.Department of Pharmacy, Gansu Provincial People's Hospital Lanzhou 730000, China.Department of Pharmacy, Dongzhimen Hospital, Beijing University of Chinese Medicine Beijing 100700, China.Department of Pharmacy, Gansu Provincial People's Hospital Lanzhou 730000, China.Department of Pharmacy, Dongfang Hospital, Beijing University of Chinese Medicine Beijing 100078, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

33164379

Citation

Zhi-Rong, G U., et al. "[Study On Drug Properties and Syndrome-symptom-formula-herb Network of Traditional Chinese Medicine in Treatment of Effort Angina Pectoris Based On Data Visualization]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 45, no. 18, 2020, pp. 4482-4489.
Zhi-Rong GU, Chun-Miao X, Xin L, et al. [Study on drug properties and syndrome-symptom-formula-herb network of traditional Chinese medicine in treatment of effort angina pectoris based on data visualization]. Zhongguo Zhong Yao Za Zhi. 2020;45(18):4482-4489.
Zhi-Rong, G. U., Chun-Miao, X., Xin, L., Xiao-Yan, S. U., Lin, P., Bin, G. E., & Jun-Ling, C. (2020). [Study on drug properties and syndrome-symptom-formula-herb network of traditional Chinese medicine in treatment of effort angina pectoris based on data visualization]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 45(18), 4482-4489. https://doi.org/10.19540/j.cnki.cjcmm.20200115.504
Zhi-Rong GU, et al. [Study On Drug Properties and Syndrome-symptom-formula-herb Network of Traditional Chinese Medicine in Treatment of Effort Angina Pectoris Based On Data Visualization]. Zhongguo Zhong Yao Za Zhi. 2020;45(18):4482-4489. PubMed PMID: 33164379.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on drug properties and syndrome-symptom-formula-herb network of traditional Chinese medicine in treatment of effort angina pectoris based on data visualization]. AU - Zhi-Rong,G U, AU - Chun-Miao,Xue, AU - Xin,Lyu, AU - Xiao-Yan,S U, AU - Lin,Pan, AU - Bin,G E, AU - Jun-Ling,Cao, PY - 2020/11/9/entrez PY - 2020/11/10/pubmed PY - 2020/11/11/medline KW - data visualization KW - drug property KW - effort angina pectoris KW - formula KW - frequency analysis KW - symptom KW - syndrome KW - traditional Chinese medicine SP - 4482 EP - 4489 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 45 IS - 18 N2 - This article aims to explore drug properties and syndrome-symptom-formula-herb network of traditional Chinese medicine(TCM) in the treatment of effort angina pectoris based on data visualization, and provide useful references for clinical diagnosis and treatment. Literatures about TCM formula for effort angina pectoris from databases of CNKI, WanFang, VIP, and CBM were retrieved from the database-building to August 31, 2019. The name of syndromes, symptoms, formulas, and herbs were standardized, and the corresponding databases were established. Frequency, four properties, five flavors, and meridian were analyzed. Visualized syndrome-symptom-formula-herb network relationships were constructed by bioinformatic analysis. A total of 202 formulas were included, and 218 kinds of TCM were involved. There were 56 herbs with the use frequency of more than 10, involving 78 syndromes and 162 symptoms. TCM formulas in the treatment of effort angina pectoris mainly included herbs with effects in invigorating blood circulation and eliminating stasis, tonifying deficiency, Qi-regulating, resolving phlegm and relieving cough and asthma, relieving exterior disorder, and heat-clearing. The main properties were warm, cold and mild(accounting for 95%); the main flavors were sweet, bitter and pungent(accounting for 89%); and meridians were mainly spleen, heart, liver, lung, stomach, and kidney(accounting for 89%). Syndrome-symptom-formula-herb network of TCM in the treatment of effort angina pectoris were successfully constructed. The high-frequency syndromes of this disease were Qi deficiency and blood stasis, Qi stagnation and blood stasis, heart blood stasis, and turbid phlegm and blood stasis, and its high-frequency symptoms were chest tightness, chest pain, palpitation, shortness of breath, fatigue, dark purple tongue, spontaneous sweating, and abundant phlegm. High-frequency core formulas of this disease included Xuefu Zhuyu Decoction, Gualou Xiebai Banxia Decoction, Danshen Decoction, Taohong Siwu Decoction, Shengmai Powder, Buyang Huanwu Decoction and Zhigancao Decoction, and their core herbs included Salviae Miltiorrhizae Radix et Rhizoma, Astragali Radix, Chuanxiong Rhizoma, Ginseng Radix et Rhizoma, Trichosanthis Fructus, Allium Macrostemonis Bulbus, Notoginseng Radix et Rhizoma, Persicae Semen, Carthami Flos, Atractylodis Macrocephalae Rhizoma, Angelicae Sinensis Radix, Paeoniae Radix Rubra, Poria, Pinelliae Rhizoma Praeparatum. Drug properties and syndrome-symptom-formula-herb networks of TCM in the treatment of effort angina pectoris can realize data visualization, objectively reflect the clinical syndrome differentiation and rule of medication, and provide reference for clinical diagnosis and treatment. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/33164379/[Study_on_drug_properties_and_syndrome_symptom_formula_herb_network_of_traditional_Chinese_medicine_in_treatment_of_effort_angina_pectoris_based_on_data_visualization]_ DB - PRIME DP - Unbound Medicine ER -