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Kinetic changes in virology, specific antibody response and imaging during the clinical course of COVID-19: a descriptive study.
BMC Infect Dis. 2020 Nov 10; 20(1):818.BI

Abstract

BACKGROUND

To explore the kinetic changes in virology, specific antibody response and imaging during the clinical course of COVID-19.

METHODS

This observational study enrolled 20 patients with COVID-19, who were hospitalized between January 20-April 6, 2020, in the two COVID-19 designated hospitals of Zhoushan, Zhejiang and Rushan, Shandong, China, The laboratory findings, imaging, serum response to viral infection, and viral RNA level in the throat and stool samples were assessed from onset to recovery phase in patients with COVID-19.

RESULTS

SARS-COV-2 RNA was positive as early as day four. It remained positive until day 55 post-onset in the sputum-throat swabs and became negative in most cases (55%) within 14 days after onset. Lymphocytopenia occurred in 40% (8/20) of patients during the peak infection period and returned to normal at week five. The most severe inflammation in the lungs appeared in week 2 or 3 after onset, and this was completely absorbed between week 6 and 8 in 85.7% of patients. All patients had detectable antibodies to the receptor binding domain (RBD), and 95% of these patients had IgG to viral N proteins. The antibody titer peaked at week four. Anti-S IgM was positive in 7 of 20 patients after week three.

CONCLUSIONS

All COVID-19 patients in this study were self-limiting and recovered well though it may take as long as 6-8 weeks. Our findings on the kinetic changes in imaging, serum response to viral infection and viral RNA level may help understand pathogenesis and define clinical course of COVID-19.

Links

Publisher Full Text
ncbi.nlm.nih.gov
bmcinfectdis.biomedcentral.com
PMC Free PDF

Authors+Show Affiliations

Wang QJ
Department of Infectious Diseases, Zhoushan Hospital, Wenzhou Medical University, NO.739 Dingshen Road, Zhoushan City, 316021, Zhejiang, China.
Yao YZ
Department of Clinical Laboratory, Zhoushan Hospital, WenZhou Medical University, Zhoushan, 316021, Zhejiang, China.
Song JS
Department of Emergency, Rushan People's Hospital, Shandong, 264500, Rushan, China.
Wang Q
Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Xu LY
Cell and Molecular Biology Laboratory, Zhoushan Hospital, Wenzhou medical University, Zhoushan, 316021, Zhejiang, China.
Bao ZJ
Department of Clinical Laboratory, Zhoushan Hospital, WenZhou Medical University, Zhoushan, 316021, Zhejiang, China.
Mao DW
Department of Infectious Diseases, Zhoushan Hospital, Wenzhou Medical University, NO.739 Dingshen Road, Zhoushan City, 316021, Zhejiang, China.
Zhou JH
Cell and Molecular Biology Laboratory, Zhoushan Hospital, Wenzhou medical University, Zhoushan, 316021, Zhejiang, China.
Zhang ZE
Department of Infectious Diseases, Zhoushan Hospital, Wenzhou Medical University, NO.739 Dingshen Road, Zhoushan City, 316021, Zhejiang, China.
Wang Y
Department of Infectious Diseases, Zhoushan Hospital, Wenzhou Medical University, NO.739 Dingshen Road, Zhoushan City, 316021, Zhejiang, China.
Li YW
Department of Clinical Laboratory, Zhoushan Hospital, WenZhou Medical University, Zhoushan, 316021, Zhejiang, China.
Wang HP
Department of Radiology Diagnostic Center, Zhoushan Hospital, WenZhou Medical University, Zhoushan, 316021, Zhejiang, China.
Li L
Department of Respiratory Medicine, Zhoushan Hospital, WenZhou Medical University, Zhoushan, 316021, Zhejiang, China.
Pan HY
Department of Gastroenterology, Zhoushan Hospital, WenZhou Medical University, Zhoushan, 316021, Zhejiang, China.
Zhang GQ
Department of Gastrointestinal Surgery, Zhoushan Hospital, WenZhou Medical University, Zhoushan, 316021, Zhejiang, China.
Li SB
Department of Infectious Diseases, Zhoushan Hospital, Wenzhou Medical University, NO.739 Dingshen Road, Zhoushan City, 316021, Zhejiang, China. lsb0398@163.com.

MeSH

AdolescentAdultAgedAntibodies, ViralBetacoronavirusCOVID-19COVID-19 TestingCOVID-19 VaccinesChildChinaClinical Laboratory TechniquesCoronavirus InfectionsCoronavirus Nucleocapsid ProteinsFemaleHumansImmunoglobulin GImmunoglobulin MLungMaleMiddle AgedNucleocapsid ProteinsPandemicsPhosphoproteinsPneumonia, ViralRNA, ViralReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionSARS-CoV-2SputumTomography, X-Ray ComputedYoung Adult

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

33167900

Citation

Wang, Qiu-Jing, et al. "Kinetic Changes in Virology, Specific Antibody Response and Imaging During the Clinical Course of COVID-19: a Descriptive Study." BMC Infectious Diseases, vol. 20, no. 1, 2020, p. 818.
Wang QJ, Yao YZ, Song JS, et al. Kinetic changes in virology, specific antibody response and imaging during the clinical course of COVID-19: a descriptive study. BMC Infect Dis. 2020;20(1):818.
Wang, Q. J., Yao, Y. Z., Song, J. S., Wang, Q., Xu, L. Y., Bao, Z. J., Mao, D. W., Zhou, J. H., Zhang, Z. E., Wang, Y., Li, Y. W., Wang, H. P., Li, L., Pan, H. Y., Zhang, G. Q., & Li, S. B. (2020). Kinetic changes in virology, specific antibody response and imaging during the clinical course of COVID-19: a descriptive study. BMC Infectious Diseases, 20(1), 818. https://doi.org/10.1186/s12879-020-05549-8
Wang QJ, et al. Kinetic Changes in Virology, Specific Antibody Response and Imaging During the Clinical Course of COVID-19: a Descriptive Study. BMC Infect Dis. 2020 Nov 10;20(1):818. PubMed PMID: 33167900.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinetic changes in virology, specific antibody response and imaging during the clinical course of COVID-19: a descriptive study. AU - Wang,Qiu-Jing, AU - Yao,Yan-Zhen, AU - Song,Jun-Shuai, AU - Wang,Qiao, AU - Xu,Li-Yun, AU - Bao,Zhou-Jun, AU - Mao,Dai-Wen, AU - Zhou,Ji-Hang, AU - Zhang,Zhe-En, AU - Wang,Yan, AU - Li,Yi-Wei, AU - Wang,He-Ping, AU - Li,Lue, AU - Pan,Hai-Yan, AU - Zhang,Guo-Qiang, AU - Li,Shi-Bo, Y1 - 2020/11/10/ PY - 2020/07/02/received PY - 2020/10/27/accepted PY - 2020/11/10/entrez PY - 2020/11/11/pubmed PY - 2020/11/20/medline KW - Antibody response and qRT-PCR KW - COVID-19 KW - Lung image KW - SARS-CoV-2 SP - 818 EP - 818 JF - BMC infectious diseases JO - BMC Infect Dis VL - 20 IS - 1 N2 - BACKGROUND: To explore the kinetic changes in virology, specific antibody response and imaging during the clinical course of COVID-19. METHODS: This observational study enrolled 20 patients with COVID-19, who were hospitalized between January 20-April 6, 2020, in the two COVID-19 designated hospitals of Zhoushan, Zhejiang and Rushan, Shandong, China, The laboratory findings, imaging, serum response to viral infection, and viral RNA level in the throat and stool samples were assessed from onset to recovery phase in patients with COVID-19. RESULTS: SARS-COV-2 RNA was positive as early as day four. It remained positive until day 55 post-onset in the sputum-throat swabs and became negative in most cases (55%) within 14 days after onset. Lymphocytopenia occurred in 40% (8/20) of patients during the peak infection period and returned to normal at week five. The most severe inflammation in the lungs appeared in week 2 or 3 after onset, and this was completely absorbed between week 6 and 8 in 85.7% of patients. All patients had detectable antibodies to the receptor binding domain (RBD), and 95% of these patients had IgG to viral N proteins. The antibody titer peaked at week four. Anti-S IgM was positive in 7 of 20 patients after week three. CONCLUSIONS: All COVID-19 patients in this study were self-limiting and recovered well though it may take as long as 6-8 weeks. Our findings on the kinetic changes in imaging, serum response to viral infection and viral RNA level may help understand pathogenesis and define clinical course of COVID-19. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/33167900/Kinetic_changes_in_virology_specific_antibody_response_and_imaging_during_the_clinical_course_of_COVID_19:_a_descriptive_study_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05549-8 DB - PRIME DP - Unbound Medicine ER -