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Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study.
BMJ Open. 2020 11 10; 10(11):e042398.BO

Abstract

OBJECTIVES

To describe demographic, clinical, radiological and laboratory characteristics, as well as outcomes, of patients admitted for COVID-19 in a secondary hospital.

DESIGN AND SETTING

Retrospective case series of sequentially hospitalised patients with confirmed SARS-CoV-2, at Infanta Leonor University Hospital (ILUH) in Madrid, Spain.

PARTICIPANTS

All patients attended at ILUH testing positive to reverse transcriptase-PCR on nasopharyngeal swabs and diagnosed with COVID-19 between 1 March 2020 and 28 May 2020.

RESULTS

A total of 1549 COVID-19 cases were included (median age 69 years (IQR 55.0-81.0), 57.5% men). 78.2% had at least one underlying comorbidity, the most frequent was hypertension (55.8%). Most frequent symptoms at presentation were fever (75.3%), cough (65.7%) and dyspnoea (58.1%). 81 (5.8%) patients were admitted to the intensive care unit (ICU) (median age 62 years (IQR 51-71); 74.1% men; median length of stay 9 days (IQR 5-19)) 82.7% of them needed invasive ventilation support. 1393 patients had an outcome at the end of the study period (case fatality ratio: 21.2% (296/1393)). The independent factors associated with fatality (OR; 95% CI): age (1.07; 1.06 to 1.09), male sex (2.86; 1.85 to 4.50), neurological disease (1.93; 1.19 to 3.13), chronic kidney disease (2.83; 1.40 to 5.71) and neoplasia (4.29; 2.40 to 7.67). The percentage of hospital beds occupied with COVID-19 almost doubled (702/361), with the number of patients in ICU quadrupling its capacity (32/8). Median length of stay was 9 days (IQR 6-14).

CONCLUSIONS

This study provides clinical characteristics, complications and outcomes of patients with COVID-19 admitted to a European secondary hospital. Fatal outcomes were similar to those reported by hospitals with a higher level of complexity.

Authors+Show Affiliations

Preventive Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain ejgonzalezbuitrago@salud.madrid.org.Preventive Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Internal Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Preventive Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Pharmacy Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Pharmacy Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Pharmacy Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Preventive Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Internal Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Preventive Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Emergency Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Emergency Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Anesthesiology Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Intensive Care Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Internal Medicine Department, Hospital Universitario Infanta Leonor, Madrid, Spain.Pediatrics Department, Hospital Universitario Infanta Leonor, Madrid, Spain.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33172949

Citation

Jiménez, Eva, et al. "Characteristics, Complications and Outcomes Among 1549 Patients Hospitalised With COVID-19 in a Secondary Hospital in Madrid, Spain: a Retrospective Case Series Study." BMJ Open, vol. 10, no. 11, 2020, pp. e042398.
Jiménez E, Fontán-Vela M, Valencia J, et al. Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study. BMJ Open. 2020;10(11):e042398.
Jiménez, E., Fontán-Vela, M., Valencia, J., Fernandez-Jimenez, I., Álvaro-Alonso, E. A., Izquierdo-García, E., Lazaro Cebas, A., Gallego Ruiz-Elvira, E., Troya, J., Tebar-Martinez, A. J., Garcia-Marina, B., Peña-Lillo, G., Abad-Motos, A., Macaya, L., Ryan, P., & Pérez-Butragueño, M. (2020). Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study. BMJ Open, 10(11), e042398. https://doi.org/10.1136/bmjopen-2020-042398
Jiménez E, et al. Characteristics, Complications and Outcomes Among 1549 Patients Hospitalised With COVID-19 in a Secondary Hospital in Madrid, Spain: a Retrospective Case Series Study. BMJ Open. 2020 11 10;10(11):e042398. PubMed PMID: 33172949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics, complications and outcomes among 1549 patients hospitalised with COVID-19 in a secondary hospital in Madrid, Spain: a retrospective case series study. AU - Jiménez,Eva, AU - Fontán-Vela,Mario, AU - Valencia,Jorge, AU - Fernandez-Jimenez,Ines, AU - Álvaro-Alonso,Elena Alba, AU - Izquierdo-García,Elsa, AU - Lazaro Cebas,Andrea, AU - Gallego Ruiz-Elvira,Elisa, AU - Troya,Jesús, AU - Tebar-Martinez,Ana Josefa, AU - Garcia-Marina,Belén, AU - Peña-Lillo,Gabriela, AU - Abad-Motos,Ane, AU - Macaya,Laura, AU - Ryan,Pablo, AU - Pérez-Butragueño,Mario, AU - ,, AU - ,, Y1 - 2020/11/10/ PY - 2020/11/11/entrez PY - 2020/11/12/pubmed PY - 2020/11/20/medline KW - COVID-19 KW - epidemiology KW - infectious diseases KW - public health SP - e042398 EP - e042398 JF - BMJ open JO - BMJ Open VL - 10 IS - 11 N2 - OBJECTIVES: To describe demographic, clinical, radiological and laboratory characteristics, as well as outcomes, of patients admitted for COVID-19 in a secondary hospital. DESIGN AND SETTING: Retrospective case series of sequentially hospitalised patients with confirmed SARS-CoV-2, at Infanta Leonor University Hospital (ILUH) in Madrid, Spain. PARTICIPANTS: All patients attended at ILUH testing positive to reverse transcriptase-PCR on nasopharyngeal swabs and diagnosed with COVID-19 between 1 March 2020 and 28 May 2020. RESULTS: A total of 1549 COVID-19 cases were included (median age 69 years (IQR 55.0-81.0), 57.5% men). 78.2% had at least one underlying comorbidity, the most frequent was hypertension (55.8%). Most frequent symptoms at presentation were fever (75.3%), cough (65.7%) and dyspnoea (58.1%). 81 (5.8%) patients were admitted to the intensive care unit (ICU) (median age 62 years (IQR 51-71); 74.1% men; median length of stay 9 days (IQR 5-19)) 82.7% of them needed invasive ventilation support. 1393 patients had an outcome at the end of the study period (case fatality ratio: 21.2% (296/1393)). The independent factors associated with fatality (OR; 95% CI): age (1.07; 1.06 to 1.09), male sex (2.86; 1.85 to 4.50), neurological disease (1.93; 1.19 to 3.13), chronic kidney disease (2.83; 1.40 to 5.71) and neoplasia (4.29; 2.40 to 7.67). The percentage of hospital beds occupied with COVID-19 almost doubled (702/361), with the number of patients in ICU quadrupling its capacity (32/8). Median length of stay was 9 days (IQR 6-14). CONCLUSIONS: This study provides clinical characteristics, complications and outcomes of patients with COVID-19 admitted to a European secondary hospital. Fatal outcomes were similar to those reported by hospitals with a higher level of complexity. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/33172949/Characteristics_complications_and_outcomes_among_1549_patients_hospitalised_with_COVID_19_in_a_secondary_hospital_in_Madrid_Spain:_a_retrospective_case_series_study_ L2 - https://bmjopen.bmj.com/lookup/pmidlookup?view=long&pmid=33172949 DB - PRIME DP - Unbound Medicine ER -