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Clinical characteristics of 199 discharged patients with COVID-19 in Fujian Province: A multicenter retrospective study between January 22nd and February 27th, 2020.
PLoS One. 2020; 15(11):e0242307.Plos

Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and the world since first broke out in Wuhan, China. The outbreak that started from January 22, 2020, in Fujian Province has been controlled as the number of indigenous cases has not increased since March. We aimed to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China.

METHODS

In this retrospective, multicenter study, we collected and analyzed the epidemiological, clinical, and laboratory data of all cases confirmed by nucleic acid tests in five designated hospitals in Fujian Province between January 22 and February 27, 2020. All patients were followed up until discharge. COVID-19 severity was classified as mild, moderate, severe, or critical.

RESULTS

Of 199 discharged patients with COVID-19, 105 patients were male, with a median age of 46.3 years, and 17 patients were severe, and 5 patients were critical on admission. Hypertension and diabetes were the most common comorbidities. The symptoms at illness onset were mainly fever (76.4%), cough (60.8%), and myalgia or fatigue (27.6%). A total of 96.5% of patients had abnormal imaging findings on chest computed tomography. Lymphopenia (37.2%) and hypoxemia (13.6%) were observed. Acute respiratory distress syndrome and respiratory failure occurred in 9 patients (4.5%) and 8 patients (4.0%) respectively. One patient died and the others were cured and discharged with the median hospital stay of 19 days. Old age was negatively correlated with lymphocyte count (r = - 0.296, p < 0.001) and oxygenation index (r = - 0.263, p = 0.001). Bivariate regression analysis revealed that old age (≥ 75 years), hypertension, diabetes, and lymphopenia were correlated with the severity of COVID-19.

CONCLUSIONS

Patients in Fujian Province were mostly nonsevere cases with mild or moderate symptoms, and had a lower mortality than patients in Wuhan (4.3%-15%). Older age, hypertension, diabetes, and lymphopenia were risk factors for severity of COVID-19.

Authors+Show Affiliations

Department of Pulmonary Medicine, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, Fujian, China. Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.Department of Pulmonary Medicine, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, Fujian, China.Department of Pulmonary and Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian, China.Department of Pulmonary and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China.Department of Pulmonary and Critical Care Medicine, Affiliated Hospital of Putian University, Putian, Fujian, China.Department of Respiratory Medicine, Fuzhou Pulmonary Hospital, Fuzhou, Fujian, China.Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China.Department of Pulmonary and Critical Care Medicine, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian, China.Department of Pulmonary and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian, China.Department of Respiratory Medicine, Fuzhou Pulmonary Hospital, Fuzhou, Fujian, China.Department of Respiratory Medicine, Fuzhou Pulmonary Hospital, Fuzhou, Fujian, China.Department of Pulmonary Medicine, Xiamen Branch, Zhongshan Hospital, Fudan University, Xiamen, Fujian, China. Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33180862

Citation

Wang, Sijiao, et al. "Clinical Characteristics of 199 Discharged Patients With COVID-19 in Fujian Province: a Multicenter Retrospective Study Between January 22nd and February 27th, 2020." PloS One, vol. 15, no. 11, 2020, pp. e0242307.
Wang S, Chen Z, Lin Y, et al. Clinical characteristics of 199 discharged patients with COVID-19 in Fujian Province: A multicenter retrospective study between January 22nd and February 27th, 2020. PLoS One. 2020;15(11):e0242307.
Wang, S., Chen, Z., Lin, Y., Lin, L., Lin, Q., Fang, S., Shi, Y., Zhuang, X., Ye, Y., Wang, T., Zhang, H., & Shao, C. (2020). Clinical characteristics of 199 discharged patients with COVID-19 in Fujian Province: A multicenter retrospective study between January 22nd and February 27th, 2020. PloS One, 15(11), e0242307. https://doi.org/10.1371/journal.pone.0242307
Wang S, et al. Clinical Characteristics of 199 Discharged Patients With COVID-19 in Fujian Province: a Multicenter Retrospective Study Between January 22nd and February 27th, 2020. PLoS One. 2020;15(11):e0242307. PubMed PMID: 33180862.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical characteristics of 199 discharged patients with COVID-19 in Fujian Province: A multicenter retrospective study between January 22nd and February 27th, 2020. AU - Wang,Sijiao, AU - Chen,Zhisheng, AU - Lin,Yijian, AU - Lin,Li, AU - Lin,Qunying, AU - Fang,Sufang, AU - Shi,Yonghong, AU - Zhuang,Xibin, AU - Ye,Yuming, AU - Wang,Ting, AU - Zhang,Hongying, AU - Shao,Changzhou, Y1 - 2020/11/12/ PY - 2020/06/14/received PY - 2020/10/31/accepted PY - 2020/11/12/entrez PY - 2020/11/13/pubmed PY - 2020/11/24/medline SP - e0242307 EP - e0242307 JF - PloS one JO - PLoS One VL - 15 IS - 11 N2 - BACKGROUND: Coronavirus disease 2019 (COVID-19) has quickly spread throughout the country and the world since first broke out in Wuhan, China. The outbreak that started from January 22, 2020, in Fujian Province has been controlled as the number of indigenous cases has not increased since March. We aimed to describe the clinical characteristics of patients with COVID-19 in Fujian Province, China. METHODS: In this retrospective, multicenter study, we collected and analyzed the epidemiological, clinical, and laboratory data of all cases confirmed by nucleic acid tests in five designated hospitals in Fujian Province between January 22 and February 27, 2020. All patients were followed up until discharge. COVID-19 severity was classified as mild, moderate, severe, or critical. RESULTS: Of 199 discharged patients with COVID-19, 105 patients were male, with a median age of 46.3 years, and 17 patients were severe, and 5 patients were critical on admission. Hypertension and diabetes were the most common comorbidities. The symptoms at illness onset were mainly fever (76.4%), cough (60.8%), and myalgia or fatigue (27.6%). A total of 96.5% of patients had abnormal imaging findings on chest computed tomography. Lymphopenia (37.2%) and hypoxemia (13.6%) were observed. Acute respiratory distress syndrome and respiratory failure occurred in 9 patients (4.5%) and 8 patients (4.0%) respectively. One patient died and the others were cured and discharged with the median hospital stay of 19 days. Old age was negatively correlated with lymphocyte count (r = - 0.296, p < 0.001) and oxygenation index (r = - 0.263, p = 0.001). Bivariate regression analysis revealed that old age (≥ 75 years), hypertension, diabetes, and lymphopenia were correlated with the severity of COVID-19. CONCLUSIONS: Patients in Fujian Province were mostly nonsevere cases with mild or moderate symptoms, and had a lower mortality than patients in Wuhan (4.3%-15%). Older age, hypertension, diabetes, and lymphopenia were risk factors for severity of COVID-19. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/33180862/Clinical_characteristics_of_199_discharged_patients_with_COVID_19_in_Fujian_Province:_A_multicenter_retrospective_study_between_January_22nd_and_February_27th_2020_ L2 - https://dx.plos.org/10.1371/journal.pone.0242307 DB - PRIME DP - Unbound Medicine ER -