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Emerging potential of cannabidiol in reversing proteinopathies.
Ageing Res Rev. 2021 01; 65:101209.AR

Abstract

The aberrant accumulation of disease-specific protein aggregates accompanying cognitive decline is a pathological hallmark of age-associated neurological disorders, also termed as proteinopathies, including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and multiple sclerosis. Along with oxidative stress and neuroinflammation, disruption in protein homeostasis (proteostasis), a network that constitutes protein surveillance system, plays a pivotal role in the pathobiology of these dementia disorders. Cannabidiol (CBD), a non-psychotropic phytocannabinoid of Cannabis sativa, is known for its pleiotropic neuropharmacological effects on the central nervous system, including the ability to abate oxidative stress, neuroinflammation, and protein misfolding. Over the past years, compelling evidence has documented disease-modifying role of CBD in various preclinical and clinical models of neurological disorders, suggesting the potential therapeutic implications of CBD in these disorders. Because of its putative role in the proteostasis network in particular, CBD could be a potent modulator for reversing not only age-associated neurodegeneration but also other protein misfolding disorders. However, the current understanding is insufficient to underpin this proposition. In this review, we discuss the potentiality of CBD as a pharmacological modulator of the proteostasis network, highlighting its neuroprotective and aggregates clearing roles in the neurodegenerative disorders. We anticipate that the current effort will advance our knowledge on the implication of CBD in proteostasis network, opening up a new therapeutic window for aging proteinopathies.

Authors+Show Affiliations

Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea.Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Islamic University, Kushtia 7003, Bangladesh.Department of Pharmacy, Faculty of Life and Earth Sciences, Jagannath University, Dhaka 1100, Bangladesh; Department of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, Kumira, Chittagong 4318, Bangladesh.Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea.Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea.Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea; Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh.Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea.Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea.Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea.Department of Anatomy, Dongguk University College of Medicine, Gyeongju 38066, Republic of Korea. Electronic address: moonis@dongguk.ac.kr.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

33181336

Citation

Dash, Raju, et al. "Emerging Potential of Cannabidiol in Reversing Proteinopathies." Ageing Research Reviews, vol. 65, 2021, p. 101209.
Dash R, Ali MC, Jahan I, et al. Emerging potential of cannabidiol in reversing proteinopathies. Ageing Res Rev. 2021;65:101209.
Dash, R., Ali, M. C., Jahan, I., Munni, Y. A., Mitra, S., Hannan, M. A., Timalsina, B., Oktaviani, D. F., Choi, H. J., & Moon, I. S. (2021). Emerging potential of cannabidiol in reversing proteinopathies. Ageing Research Reviews, 65, 101209. https://doi.org/10.1016/j.arr.2020.101209
Dash R, et al. Emerging Potential of Cannabidiol in Reversing Proteinopathies. Ageing Res Rev. 2021;65:101209. PubMed PMID: 33181336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Emerging potential of cannabidiol in reversing proteinopathies. AU - Dash,Raju, AU - Ali,Md Chayan, AU - Jahan,Israt, AU - Munni,Yeasmin Akter, AU - Mitra,Sarmistha, AU - Hannan,Md Abdul, AU - Timalsina,Binod, AU - Oktaviani,Diyah Fatimah, AU - Choi,Ho Jin, AU - Moon,Il Soo, Y1 - 2020/11/09/ PY - 2020/08/15/received PY - 2020/10/22/revised PY - 2020/11/04/accepted PY - 2020/11/13/pubmed PY - 2021/2/23/medline PY - 2020/11/12/entrez KW - Alzheimer's disease KW - Cannabidiol KW - Huntington's disease KW - Multiple sclerosis KW - Parkinson’s disease KW - Prion disease KW - Proteinopathies SP - 101209 EP - 101209 JF - Ageing research reviews JO - Ageing Res Rev VL - 65 N2 - The aberrant accumulation of disease-specific protein aggregates accompanying cognitive decline is a pathological hallmark of age-associated neurological disorders, also termed as proteinopathies, including Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and multiple sclerosis. Along with oxidative stress and neuroinflammation, disruption in protein homeostasis (proteostasis), a network that constitutes protein surveillance system, plays a pivotal role in the pathobiology of these dementia disorders. Cannabidiol (CBD), a non-psychotropic phytocannabinoid of Cannabis sativa, is known for its pleiotropic neuropharmacological effects on the central nervous system, including the ability to abate oxidative stress, neuroinflammation, and protein misfolding. Over the past years, compelling evidence has documented disease-modifying role of CBD in various preclinical and clinical models of neurological disorders, suggesting the potential therapeutic implications of CBD in these disorders. Because of its putative role in the proteostasis network in particular, CBD could be a potent modulator for reversing not only age-associated neurodegeneration but also other protein misfolding disorders. However, the current understanding is insufficient to underpin this proposition. In this review, we discuss the potentiality of CBD as a pharmacological modulator of the proteostasis network, highlighting its neuroprotective and aggregates clearing roles in the neurodegenerative disorders. We anticipate that the current effort will advance our knowledge on the implication of CBD in proteostasis network, opening up a new therapeutic window for aging proteinopathies. SN - 1872-9649 UR - https://www.unboundmedicine.com/medline/citation/33181336/Emerging_potential_of_cannabidiol_in_reversing_proteinopathies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1568-1637(20)30344-5 DB - PRIME DP - Unbound Medicine ER -