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Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020.
Euro Surveill. 2020 11; 25(45)ES

Abstract

We analysed factors associated with neutralising antibody levels in 330 convalescent plasma donors. Women and younger donors were more likely not to have measurable neutralising antibodies, while higher antibody levels were observed in men, in older donors and in those who had been hospitalised. These data will be of value in the timely recruitment of convalescent plasma donors most likely to have high levels of neutralising antibodies for ongoing studies investigating its effectiveness.

Authors+Show Affiliations

Statistics and Clinical Studies, NHS Blood and Transplant, Bristol, United Kingdom.Statistics and Clinical Studies, NHS Blood and Transplant, Bristol, United Kingdom.NHS Blood and Transplant, Oxford, United Kingdom. Radcliffe Department of Medicine and BRC Haematology Theme, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.Microbiology Services, NHS Blood and Transplant, London, United Kingdom.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33183404

Citation

Mehew, Jennifer, et al. "Convalescent Plasma for COVID-19: Male Gender, Older Age and Hospitalisation Associated With High Neutralising Antibody Levels, England, 22 April to 12 May 2020." Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, vol. 25, no. 45, 2020.
Mehew J, Johnson R, Roberts D, et al. Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020. Euro Surveill. 2020;25(45).
Mehew, J., Johnson, R., Roberts, D., & Harvala, H. (2020). Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020. Euro Surveillance : Bulletin Europeen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin, 25(45). https://doi.org/10.2807/1560-7917.ES.2020.25.45.2001754
Mehew J, et al. Convalescent Plasma for COVID-19: Male Gender, Older Age and Hospitalisation Associated With High Neutralising Antibody Levels, England, 22 April to 12 May 2020. Euro Surveill. 2020;25(45) PubMed PMID: 33183404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Convalescent plasma for COVID-19: male gender, older age and hospitalisation associated with high neutralising antibody levels, England, 22 April to 12 May 2020. AU - Mehew,Jennifer, AU - Johnson,Rachel, AU - Roberts,David, AU - Harvala,Heli, PY - 2020/11/13/entrez PY - 2020/11/14/pubmed PY - 2020/11/20/medline KW - COVID-19 KW - SARS-CoV-2 KW - convalescent plasma KW - multivariable model KW - neutralising antibody levels KW - plasma donor JF - Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin JO - Euro Surveill VL - 25 IS - 45 N2 - We analysed factors associated with neutralising antibody levels in 330 convalescent plasma donors. Women and younger donors were more likely not to have measurable neutralising antibodies, while higher antibody levels were observed in men, in older donors and in those who had been hospitalised. These data will be of value in the timely recruitment of convalescent plasma donors most likely to have high levels of neutralising antibodies for ongoing studies investigating its effectiveness. SN - 1560-7917 UR - https://www.unboundmedicine.com/medline/citation/33183404/Convalescent_plasma_for_COVID_19:_male_gender_older_age_and_hospitalisation_associated_with_high_neutralising_antibody_levels_England_22_April_to_12_May_2020_ L2 - http://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.45.2001754 DB - PRIME DP - Unbound Medicine ER -