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Clinical and radiographic characteristics, management and short-term outcomes of patients with COVID-19 in Wenzhou, China.
BMC Infect Dis. 2020 Nov 13; 20(1):841.BI

Abstract

BACKGROUND

Coronavirus disease 2019 (COVID-19) is an emerging viral disease. Here, we report the clinical features, management, and short-term outcomes of COVID-19 patients in Wenzhou, China, an area outside Wuhan.

METHODS

Patients admitted to the Infectious Diseases Department of Ruian People's Hospital in Wenzhou, from January 21 to February 7, 2020, were recruited. Medical data on epidemiological history, demographics, clinical characteristics, laboratory tests, chest computerized tomography (CT) examination, treatment, and short-term outcomes were retrospectively reviewed. Blood biochemistry and routine tests were examined using standard methods and automatic machines. CT examination was performed several times during hospitalization as necessary.

RESULTS

A total of 67 confirmed COVID-19 cases were diagnosed; 64 (95.4%) were common cases and three (4.5%) were severe cases. The most common symptoms at admission were fever (86.6%), cough (77.6%), productive cough (52.2%), chest distress (17.9%), and sore throat (11.9%), followed by diarrhea (7.4%), headache (7.4%), shortness of breath (6.0%), dizziness (4.5%), muscular soreness (4.5%), and running nose (4.5%). Thirty patients (47.8%) had increased C-reactive protein levels. The CT radiographs at admission showed abnormal findings in 54 (80.6%) patients. The patients were treated mainly by oxygen therapy and antiviral drugs. By March 3, 2020, all 67 patients completely recovered and had negative nucleic acid tests. The patients were discharged from the hospital and transferred to a medical observation isolation center for further observation.

CONCLUSION

Cases of COVID-19 in Wenzhou are milder and have a better prognosis, compared to those in Wuhan. Timely and appropriate screening, diagnosis, and treatment are the key to achieve good outcomes.

Authors+Show Affiliations

Department of Infectious diseases, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), 108 Wansong Road, Ruian, Wenzhou, 325200, Zhejiang Province, China.Endocrinology Department, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), Ruian City, Zhejiang Province, 325200, China.Department of Biology, Gordon College, Wenham, MA, 01984, USA.Radiography Department, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), Ruian City, Zhejiang Province, 325200, China.Department of Infectious diseases, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), 108 Wansong Road, Ruian, Wenzhou, 325200, Zhejiang Province, China.Department of Infectious diseases, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), 108 Wansong Road, Ruian, Wenzhou, 325200, Zhejiang Province, China.Health bureau of Ruian City, 333 Ruihu Road, Ruian, Wenzhou, 325200, Zhejiang Province, China.Hospital Office, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), Ruian City, Zhejiang Province, 325200, China.The Emergency Department, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), Ruian City, Zhejiang Province, 325200, China.Pneumology Department, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), Ruian City, Zhejiang Province, 325200, China.Department of Infectious diseases, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), 108 Wansong Road, Ruian, Wenzhou, 325200, Zhejiang Province, China.Pneumology Department, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), Ruian City, Zhejiang Province, 325200, China.Pneumology Department, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), Ruian City, Zhejiang Province, 325200, China.The Emergency Department, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), Ruian City, Zhejiang Province, 325200, China.The Emergency Department, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), Ruian City, Zhejiang Province, 325200, China.Department of Infectious diseases, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), 108 Wansong Road, Ruian, Wenzhou, 325200, Zhejiang Province, China. djg5011@163.com.Department of Infectious diseases, the Third Affiliated Hospital to Wenzhou Medical University (Ruian People's Hospital), 108 Wansong Road, Ruian, Wenzhou, 325200, Zhejiang Province, China. sunxue0806@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33187475

Citation

Hong, Liang, et al. "Clinical and Radiographic Characteristics, Management and Short-term Outcomes of Patients With COVID-19 in Wenzhou, China." BMC Infectious Diseases, vol. 20, no. 1, 2020, p. 841.
Hong L, Ye E, Sun G, et al. Clinical and radiographic characteristics, management and short-term outcomes of patients with COVID-19 in Wenzhou, China. BMC Infect Dis. 2020;20(1):841.
Hong, L., Ye, E., Sun, G., Wang, X., Zhang, S., Wu, Y., Xie, X., Xia, S., Zheng, X., Dong, L., Cai, F., Lou, X., Zhao, R., Hu, Y., Ruan, Z., Ding, J., & Sun, Q. (2020). Clinical and radiographic characteristics, management and short-term outcomes of patients with COVID-19 in Wenzhou, China. BMC Infectious Diseases, 20(1), 841. https://doi.org/10.1186/s12879-020-05528-z
Hong L, et al. Clinical and Radiographic Characteristics, Management and Short-term Outcomes of Patients With COVID-19 in Wenzhou, China. BMC Infect Dis. 2020 Nov 13;20(1):841. PubMed PMID: 33187475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical and radiographic characteristics, management and short-term outcomes of patients with COVID-19 in Wenzhou, China. AU - Hong,Liang, AU - Ye,Enling, AU - Sun,Gangqiang, AU - Wang,Xiaoyang, AU - Zhang,Shengguo, AU - Wu,Yanghe, AU - Xie,Xiangao, AU - Xia,Shichun, AU - Zheng,Xudong, AU - Dong,Ling, AU - Cai,Fujing, AU - Lou,Xixian, AU - Zhao,Renguo, AU - Hu,Yongqi, AU - Ruan,Zhanwei, AU - Ding,Jiguang, AU - Sun,Qingfeng, Y1 - 2020/11/13/ PY - 2020/02/25/received PY - 2020/10/19/accepted PY - 2020/11/14/entrez PY - 2020/11/15/pubmed PY - 2020/11/20/medline KW - COVID-19 KW - Clinical KW - Epidemiology KW - Radiographic characteristics KW - SARS-cov-2 SP - 841 EP - 841 JF - BMC infectious diseases JO - BMC Infect Dis VL - 20 IS - 1 N2 - BACKGROUND: Coronavirus disease 2019 (COVID-19) is an emerging viral disease. Here, we report the clinical features, management, and short-term outcomes of COVID-19 patients in Wenzhou, China, an area outside Wuhan. METHODS: Patients admitted to the Infectious Diseases Department of Ruian People's Hospital in Wenzhou, from January 21 to February 7, 2020, were recruited. Medical data on epidemiological history, demographics, clinical characteristics, laboratory tests, chest computerized tomography (CT) examination, treatment, and short-term outcomes were retrospectively reviewed. Blood biochemistry and routine tests were examined using standard methods and automatic machines. CT examination was performed several times during hospitalization as necessary. RESULTS: A total of 67 confirmed COVID-19 cases were diagnosed; 64 (95.4%) were common cases and three (4.5%) were severe cases. The most common symptoms at admission were fever (86.6%), cough (77.6%), productive cough (52.2%), chest distress (17.9%), and sore throat (11.9%), followed by diarrhea (7.4%), headache (7.4%), shortness of breath (6.0%), dizziness (4.5%), muscular soreness (4.5%), and running nose (4.5%). Thirty patients (47.8%) had increased C-reactive protein levels. The CT radiographs at admission showed abnormal findings in 54 (80.6%) patients. The patients were treated mainly by oxygen therapy and antiviral drugs. By March 3, 2020, all 67 patients completely recovered and had negative nucleic acid tests. The patients were discharged from the hospital and transferred to a medical observation isolation center for further observation. CONCLUSION: Cases of COVID-19 in Wenzhou are milder and have a better prognosis, compared to those in Wuhan. Timely and appropriate screening, diagnosis, and treatment are the key to achieve good outcomes. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/33187475/Clinical_and_radiographic_characteristics_management_and_short_term_outcomes_of_patients_with_COVID_19_in_Wenzhou_China_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05528-z DB - PRIME DP - Unbound Medicine ER -