Tags

Type your tag names separated by a space and hit enter

Foveal structure in nanophthalmos and visual acuity.
Int Ophthalmol. 2021 Mar; 41(3):805-813.IO

Abstract

PURPOSE

To evaluate the fovea in nanophthalmic eyes using spectral domain optical coherence tomography (SD-OCT) and OCT angiography (OCTA), and to investigate the relationship between the macular microstructure and visual acuity.

METHODS

This is a retrospective case series of five nanophthalmic patients. The foveal avascular zone (FAZ) area was measured in superficial and deep vascular layers with OCTA. The thickness of the inner retinal layer (IRL) was measured with SD-OCT. The ratio of the foveal and parafoveal IRL thickness (fIRL/pIRL ratio) was calculated. The relationship between these parameters and visual acuity was then investigated.

RESULTS

Eight eyes were identified as nanophthalmic with a mean axial length of 17.19 ± 1.44 mm (range: 15.71 to 19.88 mm). The mean best-corrected visual acuity (BCVA) in the logarithm of the minimum angle of resolution (logMAR) was 0.12 ± 0.18 (range: - 0.18 to 0.40). OCTA showed that FAZs were either absent or undeveloped in the superficial and deep capillary plexuses. Two patients did not show any visual impairments despite small FAZ and a shallow foveal depression. Although the BCVA was significantly correlated with the deep FAZ size, it did not correlate with the superficial FAZ size, axial length, or fIRL/pIRL ratio. However, the refractive error, axial length, and deep FAZ size were all significantly correlated with the fIRL/pIRL ratio.

CONCLUSIONS

The FAZs were commonly found to be small in the superficial and deep capillary plexuses. Although the deep FAZ size correlated with visual acuity, it is unclear whether the retinal microstructure and the FAZ size are responsible for the visual impairments observed in the same individuals.

Authors+Show Affiliations

Department of Ophthalmology and Visual Science, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minamiku, Hiroshima, 7348551, Japan. okumic@hiroshima-u.ac.jp.Department of Ophthalmology and Visual Science, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minamiku, Hiroshima, 7348551, Japan.Department of Ophthalmology and Visual Science, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minamiku, Hiroshima, 7348551, Japan.Department of Ophthalmology and Visual Science, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minamiku, Hiroshima, 7348551, Japan.Department of Ophthalmology and Visual Science, Hiroshima University Graduate School of Biomedical and Health Sciences, 1-2-3 Kasumi, Minamiku, Hiroshima, 7348551, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33188472

Citation

Okumichi, Hideaki, et al. "Foveal Structure in Nanophthalmos and Visual Acuity." International Ophthalmology, vol. 41, no. 3, 2021, pp. 805-813.
Okumichi H, Itakura K, Yuasa Y, et al. Foveal structure in nanophthalmos and visual acuity. Int Ophthalmol. 2021;41(3):805-813.
Okumichi, H., Itakura, K., Yuasa, Y., Fukuto, A., & Kiuchi, Y. (2021). Foveal structure in nanophthalmos and visual acuity. International Ophthalmology, 41(3), 805-813. https://doi.org/10.1007/s10792-020-01633-9
Okumichi H, et al. Foveal Structure in Nanophthalmos and Visual Acuity. Int Ophthalmol. 2021;41(3):805-813. PubMed PMID: 33188472.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Foveal structure in nanophthalmos and visual acuity. AU - Okumichi,Hideaki, AU - Itakura,Katsumasa, AU - Yuasa,Yuki, AU - Fukuto,Atsuhiko, AU - Kiuchi,Yoshiaki, Y1 - 2020/11/13/ PY - 2020/06/18/received PY - 2020/10/29/accepted PY - 2020/11/15/pubmed PY - 2020/11/15/medline PY - 2020/11/14/entrez KW - Foveal avascular zone KW - Nanophthalmos KW - OCT angiography KW - Visual acuity SP - 805 EP - 813 JF - International ophthalmology JO - Int Ophthalmol VL - 41 IS - 3 N2 - PURPOSE: To evaluate the fovea in nanophthalmic eyes using spectral domain optical coherence tomography (SD-OCT) and OCT angiography (OCTA), and to investigate the relationship between the macular microstructure and visual acuity. METHODS: This is a retrospective case series of five nanophthalmic patients. The foveal avascular zone (FAZ) area was measured in superficial and deep vascular layers with OCTA. The thickness of the inner retinal layer (IRL) was measured with SD-OCT. The ratio of the foveal and parafoveal IRL thickness (fIRL/pIRL ratio) was calculated. The relationship between these parameters and visual acuity was then investigated. RESULTS: Eight eyes were identified as nanophthalmic with a mean axial length of 17.19 ± 1.44 mm (range: 15.71 to 19.88 mm). The mean best-corrected visual acuity (BCVA) in the logarithm of the minimum angle of resolution (logMAR) was 0.12 ± 0.18 (range: - 0.18 to 0.40). OCTA showed that FAZs were either absent or undeveloped in the superficial and deep capillary plexuses. Two patients did not show any visual impairments despite small FAZ and a shallow foveal depression. Although the BCVA was significantly correlated with the deep FAZ size, it did not correlate with the superficial FAZ size, axial length, or fIRL/pIRL ratio. However, the refractive error, axial length, and deep FAZ size were all significantly correlated with the fIRL/pIRL ratio. CONCLUSIONS: The FAZs were commonly found to be small in the superficial and deep capillary plexuses. Although the deep FAZ size correlated with visual acuity, it is unclear whether the retinal microstructure and the FAZ size are responsible for the visual impairments observed in the same individuals. SN - 1573-2630 UR - https://www.unboundmedicine.com/medline/citation/33188472/Foveal_structure_in_nanophthalmos_and_visual_acuity_ DB - PRIME DP - Unbound Medicine ER -